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2009 Fiscal Year Annual Research Report

生体膜トランスポートソームの分子構築と生理機能

Research Project

Project/Area Number 17081015
Research InstitutionOsaka University

Principal Investigator

金井 好克  Osaka University, 医学系研究科, 教授 (60204533)

Co-Investigator(Kenkyū-buntansha) 森 泰生  京都大学, 工学研究科, 教授 (80212265)
竹島 浩  京都大学, 薬学研究科, 教授 (70212024)
鈴木 洋史  東京大学, 医学部附属病院, 教授 (80206523)
Keywords膜輸送 / トランスポーター / 複合体 / 生体膜 / 上皮輸送
Research Abstract

総括班は、本領域全体の研究の企画・広報、研究調整、研究支援、研究評価のために、平成21年度は、以下の活動を行った。(1) 班会議の開催。平成21年8月26~28日に、計画研究・公募研究及び総括班の研究代表者、研究分担者、研究協力者を中心とした3日間に渡る平成21年度第1回班会議を熊本にて開催し、各班の研究進捗報告とまとめに向けた研究計画の発表を行い、加えて最終年度の総まとめに向けた領域方針について討議した。さらに平成22年3月19日、第2回班会議および計画研究代表者会議を大阪で開催した。(2) 公開シンポジウムの開催。平成22年3月19日~20日に大阪にて、公開シンポジウム「生体膜トランスポートソームの分子構築と生理機能」を開催した。(3) 若手ワークショップの開催。平成22年3月20日、若手研究者の育成を目的とした若手ワークショップを開催し、領域終了後の若手研究者の連携と今後若手研究者が推進すべき方向性等についての議論がなされた。(4) 研究の広報。本領域の説明、紹介、その他有用情報を盛り込んだホームページを開設しており、随時更新し、領域の紹介と領域からの情報の発信に利用した。(5) 領域ニュースレターの発行。領域ニュースレターTRANSPORTSOMEを、平成21年度に3号を発行し、印刷物として配付するとともに、領域ホームページに掲載した。(6) 研究の企画、研究調整、研究支援、研究評価。平成21年4月30日(大阪)、6月4日(岡崎)、8月19日(京都)、8月26日(熊本)、10月9日(京都)、平成22年3月20日(大阪)にて、総括班企画会議を行い、研究企画、班会議・公開シンポジウムの企画とともに、研究調整、研究支援の具体的な方針と方策についての討論を行った。また、平成22年3月20日(大阪)の総括班会議では、平成21年度の研究評価を行い、同時に5年間の研究を総括し、最終のとりまとめについて討議した。

  • Research Products

    (85 results)

All 2010 2009 Other

All Journal Article (52 results) (of which Peer Reviewed: 43 results) Presentation (27 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] L-type amino acid transporter 1 inhibitors inhibit tumor cell growth.2010

    • Author(s)
      Oda K, Hosoda N, Endo H, Saito K, Tsujihara K, et al.
    • Journal Title

      Cancer Sci. 101

      Pages: 173-179

    • Peer Reviewed
  • [Journal Article] Involvement of Ca^<2+> Channel Synprint Site in Synaptic Vesicle Endocvtosis.2010

    • Author(s)
      Watanabe H, Yamashita T, Saitoh N, Kiyonaka S, et al.
    • Journal Title

      J.Neurosci. 30

      Pages: 655-660

    • Peer Reviewed
  • [Journal Article] TRPM 1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.2010

    • Author(s)
      Koike C, Obara T, Uriu Y, Numata T, Sanuki R, et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 107

      Pages: 332-337

    • Peer Reviewed
  • [Journal Article] A pathogenic C-terminus-truncated Polycistin-2 mutant enhances receptor-activated Ca^<2+> entry via association with TRPC3 and TRPC7.2010

    • Author(s)
      Miyagi K, Kiyonaka S, Yamada K, Miki T, et al.
    • Journal Title

      J.Biol.Chem. (In press)

    • Peer Reviewed
  • [Journal Article] Knockdown of Ca_v2.1 calcium channels is sufficient to induce neuro-logical disorders observed in natural occurring Cacna1a mutants in mice2010

    • Author(s)
      Saito H, Okada M, Miki T, Wakamori M, et al.
    • Journal Title

      Biochem.Biophys.Res.Comm. (In press)

    • Peer Reviewed
  • [Journal Article] An in vivo fluorescent sensor reveals intracellular Ins(1,3,4,5)P(4) dynamics in single cells.2010

    • Author(s)
      Sakaguchi R, Tainaka K, Shimada N, Nakano S, et al.
    • Journal Title

      Angew.Chem.Int.Ed. (In press)

    • Peer Reviewed
  • [Journal Article] Ca^<2+> influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells.2010

    • Author(s)
      Numaga T, Nishida M, Kiyonaka S, Kato K, et al.
    • Journal Title

      J.Cell Sci. (In press)

    • Peer Reviewed
  • [Journal Article] Differential redox regulation of ORAI channels : a mechanism to tune cellular calcium responses.2010

    • Author(s)
      Bogeski I, Kummerow C, Al-Ansary D, Koehler R, et al.
    • Journal Title

      Science Signaling (In press)

    • Peer Reviewed
  • [Journal Article] A missense mutation of the gene encoding voltage-dependent sodium channel (Na_v1.1) confers susceptibility to febrile seizures in rats.2010

    • Author(s)
      Mashimo T, Ohmori I, Ouchida M, Ohno Y, et al.
    • Journal Title

      J.Neurosci. (In press)

    • Peer Reviewed
  • [Journal Article] Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout : A Function-Based Genetic Analysis in a Japanese Population.2009

    • Author(s)
      Hirotaka Matsuo, Tappei Takad, Kimiyoshi Ichida, et al.
    • Journal Title

      Science Translational Medicine 1

      Pages: 5rall

    • Peer Reviewed
  • [Journal Article] 18F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer.2009

    • Author(s)
      Kaira K, Oriuchi N, Shimizu K, Tominaga H, et al.
    • Journal Title

      J Nucl Med. 50

      Pages: 1770-1776

    • Peer Reviewed
  • [Journal Article] A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7.2009

    • Author(s)
      Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, et al.
    • Journal Title

      J Biol Chem. 284

      Pages: 34400-34412

    • Peer Reviewed
  • [Journal Article] CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases.2009

    • Author(s)
      Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, et al.
    • Journal Title

      Ann Surg Oncol. 16

      Pages: 3473-3781

    • Peer Reviewed
  • [Journal Article] Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4.2009

    • Author(s)
      Ikebuchi Y, Takada T, Ito K, Yoshikado T, Anzai N, et al.
    • Journal Title

      Hepatol Res. 39

      Pages: 1091-1107

    • Peer Reviewed
  • [Journal Article] L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer.2009

    • Author(s)
      Imai H, Kaira K, Oriuchi N, Yanagitani N, Sunaga N, et al.
    • Journal Title

      Histopathology 54

      Pages: 804-813

    • Peer Reviewed
  • [Journal Article] Significance of system L amino acid transporter 1 (LAT-1) and 4F2 heavy chain (4F2hc) expression in human developing intestines.2009

    • Author(s)
      Ohno C, Nakanishi Y, Honma T, Henmi A, et al.
    • Journal Title

      Acta Histochem Cytochem. 42

      Pages: 73-81

    • Peer Reviewed
  • [Journal Article] Amino acid transporter LAT3 is required for podocyte development and function.2009

    • Author(s)
      Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, et al.
    • Journal Title

      J Am Soc Nephrol. 20

      Pages: 1586-1596

    • Peer Reviewed
  • [Journal Article] L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas2009

    • Author(s)
      Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, et al.
    • Journal Title

      J Surg Oncol. 99

      Pages: 433-438

    • Peer Reviewed
  • [Journal Article] Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma.2009

    • Author(s)
      Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, et al.
    • Journal Title

      Lung Cancer. 66

      Pages: 120-126

    • Peer Reviewed
  • [Journal Article] Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer.2009

    • Author(s)
      Yamauchi K, Sakurai H,Kimura T, Wiriyasermkul P, et al.
    • Journal Title

      Cancer Lett. 276

      Pages: 95-101

    • Peer Reviewed
  • [Journal Article] 栄養による固体機能制御と疾患 アミノ酸トランスポーターと癌2009

    • Author(s)
      金井好克
    • Journal Title

      細胞工学 28

      Pages: 789-793

  • [Journal Article] 上皮体制と病態2009

    • Author(s)
      金井好克
    • Journal Title

      腎臓 32

      Pages: 139-146

  • [Journal Article] Fanconi-Bickel症候群2009

    • Author(s)
      金井好克
    • Journal Title

      小児科診療 72

      Pages: 348-348

  • [Journal Article] Ca^<2+>-dependent induction of TRPM2 currents in hippocampal neurons.2009

    • Author(s)
      Olah ME, Jackson MF, et al.
    • Journal Title

      J.Physiol. 587

      Pages: 965-979

    • Peer Reviewed
  • [Journal Article] Changes in temperature preferences and energy homeostasis in dystroglycan mutants.2009

    • Author(s)
      Takeuchi K, Nakano Y, Kato U, Kaneda M, Aizu M, et al.
    • Journal Title

      Science 323

      Pages: 1740-1743

    • Peer Reviewed
  • [Journal Article] Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.2009

    • Author(s)
      Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106

      Pages: 5400-5405

    • Peer Reviewed
  • [Journal Article] Tetrameric Orail is a teardrop-shaped molecule with a long, tapered cytoplasmic domain.2009

    • Author(s)
      Maruyama Y, Ogura T, Mio K, Kato K, Kaneko T, et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 13676-13685

    • Peer Reviewed
  • [Journal Article] TRPM2 functions as lysosomal Ca^<2+> release channel in β-cells.2009

    • Author(s)
      Lange I, Yamamoto Y, Partida-Sanchez S, Mori Y
    • Journal Title

      Science Signaling 2

      Pages: Ra23

    • Peer Reviewed
  • [Journal Article] STIM protein coupling in the activation of Orai channis.2009

    • Author(s)
      Wang Y, Deng X, Zhou Y, Hendron E, Mancarella S, et al
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106

      Pages: 7391-7396

    • Peer Reviewed
  • [Journal Article] Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via PLC/diacylglycerol and PLA_2/£s-hydroxylase/20-HETE pathways.2009

    • Author(s)
      Inoue R, Jensen LJ, JianZ, Shi J, Hai L, Lurie AI, et al.
    • Journal Title

      Circ Res. 104

      Pages: 1399-1409

    • Peer Reviewed
  • [Journal Article] Targetted disruption of the voltage-dependent Ca^<2+> channel α_2/δ-1 subunit.2009

    • Author(s)
      Fuller-Bicer GA, Varadi G, Koch SE, Ishii M, et al.
    • Journal Title

      Am.J.Physiol. Heart Circ.Physiol. 297

      Pages: H117-124

    • Peer Reviewed
  • [Journal Article] Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia.2009

    • Author(s)
      Sun H-S, Jackson MF, Martin LJ, Jansen K, Teves L, et al.
    • Journal Title

      Nature Neurosci. 12

      Pages: 1300-1307

    • Peer Reviewed
  • [Journal Article] Molecular characterization of flubendiamide sensitivity in lepidopterous ryanodine receptor Ca^<2+> release channel.2009

    • Author(s)
      Kato K, Kiyonaka S, Sawa-guchi Y, Tohnishi M, et al.
    • Journal Title

      Biochemistry 48

      Pages: 10342-10352

    • Peer Reviewed
  • [Journal Article] A single circularly permuted GFP sensor for inositol-1,3,4,5-tetrakisphosphate based on a split PH domain.2009

    • Author(s)
      Sakaguchi R, Endo T, Yama-moto S, Tainaka K, et al.
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 7381-7386

    • Peer Reviewed
  • [Journal Article] 活性化学種感応のチャネル機構の探求2009

    • Author(s)
      山本伸一郎、高橋重成、清中茂樹、森泰生
    • Journal Title

      蛋白質核酸酵素 54

      Pages: 212-223

  • [Journal Article] 酸化ストレス作動性TRPチャネルの化学生理学2009

    • Author(s)
      高橋重成、山本伸一郎、森泰生
    • Journal Title

      実験医学(病態解明に迫る活性酸素シグナルと酸化ストレス) 27

      Pages: 2494-2502

  • [Journal Article] TRIPM2チャネルによる活性酸素シグナル増幅と慢性炎症の関連2009

    • Author(s)
      山本伸一郎、清水俊一、森泰生
    • Journal Title

      日本薬理学雑誌 134

      Pages: 122-126

  • [Journal Article] 脳はいま、化学の言葉でどこまで語れるか?2009

    • Author(s)
      森泰生
    • Journal Title

      化学 64

      Pages: 12-14

  • [Journal Article] 化学物質の感覚分子生物学-TRPチャネルはどのように物質を感知し脳へ伝えるか-2009

    • Author(s)
      清中茂樹、高橋重成、香西大輔、森泰生
    • Journal Title

      化学 64

      Pages: 27-33

  • [Journal Article] TRPチャネルの構造と多様な機能2009

    • Author(s)
      沼田朋大、香西大輔、外
    • Journal Title

      生化学 81

      Pages: 962-984

  • [Journal Article] Protein kinase Cε regulates local calcium signaling in airway smoothmuscle cells.2009

    • Author(s)
      Liu, Q.H., Zheng, Y.M., Korde, A.S., Li, et al.
    • Journal Title

      Am.J.Respir.Cell.Mol.Biol. 40

      Pages: 663-671

    • Peer Reviewed
  • [Journal Article] Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3 and dysferlin.2009

    • Author(s)
      Cai, C., Weisleder, N., Ko, J-K., Komazaki, S., et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 15894-15902

    • Peer Reviewed
  • [Journal Article] Essential role of TRIC-B channel in Ca^<2+>- handling of alveolar epithelium and perinatal lung maturation.2009

    • Author(s)
      Yamazaki, D., Komazaki, S., Nakanishi, H., et al.
    • Journal Title

      Development 136

      Pages: 2355-2361

    • Peer Reviewed
  • [Journal Article] Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice : decreased social contact duration in two social interaction tests.2009

    • Author(s)
      Matsuo, N., Tanda, K., Nakanishi, K., et al.
    • Journal Title

      Front.Behav.Neurosci. 3

      Pages: article

    • Peer Reviewed
  • [Journal Article] Sarcalumenin is essential for maintaining cardiac function during endurance exercise training.2009

    • Author(s)
      Jiao,Q., Bai, Y., Akaike, T., Takeshima,H., Ishikawa, Y., et al.
    • Journal Title

      Am.J.Physiol.Heart Circ.Physiol. 297

      Pages: H576-582

    • Peer Reviewed
  • [Journal Article] Molecular characterization of flubendiamide sensitivity in lepidop-terous rvanodine receptor.2009

    • Author(s)
      Kato, K., Kiyonaka, S., Sawa-guchi, Y., Tohnish, M., et al.
    • Journal Title

      Biochemistry 48

      Pages: 10342-10352

    • Peer Reviewed
  • [Journal Article] In-vitro characterization of the six clustered variants of NPC 1L1 observed in cholesterol low absorbers.2009

    • Author(s)
      Yamanashi Y, Takada T, Suzuki H.
    • Journal Title

      Pharmacogenet Genomics 19

      Pages: 884-892

    • Peer Reviewed
  • [Journal Article] Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4.2009

    • Author(s)
      Ikebuchi Y, Takada T, Ito K, Yoshikado T., et al.
    • Journal Title

      Hepatol Res 39

      Pages: 1091-1107

    • Peer Reviewed
  • [Journal Article] Vps33a Mediates RANKL Storage in Secretory Lysosomes in Osteoblastic Cells.2009

    • Author(s)
      Kariya Y, Honma M, Aoki S, Chiba A, Suzuki H.
    • Journal Title

      J Bone Miner Res 24

      Pages: 1741-1752

    • Peer Reviewed
  • [Journal Article] Common Defects of ABCG2, a High-capacity Urate Exporter, Cause Gout : A Function-based Genetic Analysis in a Japanese Population.2009

    • Author(s)
      Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, et al.
    • Journal Title

      Science Translational Medicine 1

      Pages: 41-48

    • Peer Reviewed
  • [Journal Article] Sodium-dependent phosphate cotransporter type 1 (NPT1) sequence polymorphisms in male patients with gout.

    • Author(s)
      Urano W, Taniguchi A, Anzai N, Inoue E, Kanai Y, et al.
    • Journal Title

      Ann Rheum Dis.(電子版) (In press)

    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of membrane transport of vitamin E.

    • Author(s)
      Takada T, Suzuki H.
    • Journal Title

      Mol Nutr Food Res. (In press)

    • Peer Reviewed
  • [Presentation] トランスポーター研究:辿ってきた道とこれから歩む道2010

    • Author(s)
      金井好克
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
  • [Presentation] 有機溶質トランスポートソーム:その構築と機能的意義2010

    • Author(s)
      金井好克
    • Organizer
      特定領域研究公開シンポジウム「生体膜トランスポートソームの分子構築と生理機能」
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-19
  • [Presentation] 腎皮質局所プロスタグランジンクリアランスにおける新規腎特異プロスタグランジントランスポーターの役割シンポジウム「シグナル分子トランスポーターの新たな展開」2010

    • Author(s)
      金井好克
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
  • [Presentation] 芳香族アミノ酸誘導体の抗腫瘍効果の確立2010

    • Author(s)
      金井好克
    • Organizer
      第11回未来医療交流会
    • Place of Presentation
      大阪
    • Year and Date
      2010-01-12
  • [Presentation] 新規腎特異プロスタグランジントランスポーターOAT-PGの生理機能と代謝酵素15-hydroxyprostaglandin dehydrogenaseとの共役機構2009

    • Author(s)
      金井好克
    • Organizer
      脂質メディエーターワークショップ
    • Place of Presentation
      滋賀
    • Year and Date
      2009-12-19
  • [Presentation] アミノ酸トランスポーターの機能と病態-悪性腫瘍の診断と治療の分子標的としての可能性-2009

    • Author(s)
      金井好克
    • Organizer
      第9回「アミノ酸セミナー」
    • Place of Presentation
      東京
    • Year and Date
      2009-12-18
  • [Presentation] A cholesterol transporter NPC1L1 is transcriptionally and post-transcriptionally regulated by fatty acid-related factors.2009

    • Author(s)
      高田龍平, 中村英寛, 岩柳有起, 山梨義英, 鈴木洋史
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-30
  • [Presentation] Metabolomics reveals in vivo functions of transporter2009

    • Author(s)
      金井好克
    • Organizer
      24^<th> JSSX Annual Meeting in Kyoto
    • Place of Presentation
      京都
    • Year and Date
      2009-11-29
  • [Presentation] 世界初の主要な痛風遺伝子の発見2009

    • Author(s)
      松尾洋孝, 高田龍平, 市田公美, 鈴木洋史
    • Organizer
      Science Translational Medicine創刊記念講演会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-10
  • [Presentation] 胆汁脂質輸送体発現系を用いた薬物誘発性胆汁うっ滞のメカニズム解析2009

    • Author(s)
      吉門崇, 高田龍平, 山本武人, 山道寛子, 鈴木洋史, 外
    • Organizer
      第31回胆汁酸研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-07
  • [Presentation] ウルソデオキシコール酸による胆管形態変化2009

    • Author(s)
      清水秀俊, 伊藤晃成, 鈴木洋史
    • Organizer
      第31回胆汁酸研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-07
  • [Presentation] メタボロミクスによるトランスポーターの解析 シンポジウム「メタボロミクスが切り拓くヒトシステム生物学」2009

    • Author(s)
      金井好克、曽我朋義
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
  • [Presentation] Transcriptional regulation of NPC1L1 by nuclear receptors.2009

    • Author(s)
      Takada T, Iwayanagi Y, Suzuki H.
    • Organizer
      Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-15
  • [Presentation] Amino acid transporters in cancer : relevance to its diagnosis and therapeutics2009

    • Author(s)
      金井好克
    • Organizer
      19th International Congress of Nutrition (ICN) Satellite Symposium "Advanced Knowledges of Amino Acid Research in Human Health and Disease"
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2009-10-04
  • [Presentation] トランスポーターと創薬2009

    • Author(s)
      金井好克
    • Organizer
      創薬薬理フォーラム 第17回シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-09-10
  • [Presentation] Metabolomics approaches to orphan transporters2009

    • Author(s)
      金井好克
    • Organizer
      Biomedical Transporters 2009 : Membrane transporters and impact on drug discovery
    • Place of Presentation
      Thun, Switzerland
    • Year and Date
      2009-08-12
  • [Presentation] Novel organic anion transporters and new aspects of organicanion transport in renal proximal tubules2009

    • Author(s)
      金井好克
    • Organizer
      40th NIPS International Symposium-International Joint Symposium "Physiology of Anion Transport and Cell Volume Regulation (PAT- CVR 2009)"
    • Place of Presentation
      岡崎
    • Year and Date
      2009-08-06
  • [Presentation] ost-transcriptional regulation of biliary transporter.2009

    • Author(s)
      ItoK, Takada T, Suzuki H.
    • Organizer
      IUPS2009 satellite symposium "Ion channels and membrane transport systems : function, structure and physiology"
    • Place of Presentation
      東京
    • Year and Date
      2009-08-02
  • [Presentation] Transportsome in Renal Organic Solute Transport Whole day symposium "Epithelial transport : bridges between molecules and function"2009

    • Author(s)
      金井好克
    • Organizer
      XXXVIth International Union of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-07-30
  • [Presentation] Transportsomes in Epithelial Function2009

    • Author(s)
      金井好克
    • Organizer
      XXXVIth International Union of Physiological Sciences Satellite Symposium "Ion Channels : function, structure, and physiology"
    • Place of Presentation
      京都
    • Year and Date
      2009-07-30
  • [Presentation] Vitamin E Transport by a Cholestero Importer NPC1L1.2009

    • Author(s)
      Takada T, Narushima K, Yamanashi Y, Suzuki H.
    • Organizer
      International Union of Physiological Sciences (IUPS2009)
    • Place of Presentation
      東京
    • Year and Date
      2009-07-27
  • [Presentation] Identification of USP14 as a regulatory factor of bile salt export pump.2009

    • Author(s)
      Ito K, Yamaji H, Takada T, Anzai N, Suzuki H., et al.
    • Organizer
      International Union of Physiological Sciences (IUPS2009)
    • Place of Presentation
      東京
    • Year and Date
      2009-07-27
  • [Presentation] アミノ酸トランスポーター:悪性腫瘍の診断と治療の分子標的としての可能性2009

    • Author(s)
      金井好克
    • Organizer
      第2回日Bimonthly symposiumトランスポーターシンポジウム「トランスポーター研究の新たな展開-トランスポーターを標的とした創薬への動向-」
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-02
  • [Presentation] Functional analysis of NPC1L1, acholesterol transporter. The2009

    • Author(s)
      鈴木洋史
    • Organizer
      The 5th Takeda Scicence Foundation Symposium on Pharm Sciences.
    • Place of Presentation
      東京
    • Year and Date
      2009-05-25
  • [Presentation] アミノ酸トランスポーターと細胞機能 シンポジウム「アミノ酸の新しい機能とこれからの展開」2009

    • Author(s)
      金井好克
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-22
  • [Presentation] RACK1による抗癌剤排出輸送体BCRP/ABCG2の発現制御2009

    • Author(s)
      池淵祐樹, 伊藤晃成, 鈴木洋史, 外
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-21
  • [Presentation] 臨床で観察される薬物誘発性肝障害の解析(3):胆汁形成阻害を介したイトラコナゾール誘発性肝障害2009

    • Author(s)
      吉門崇, 高田龍平, 山本武人, 鈴木洋史, 外
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-21
  • [Book] 薬物トランスポーター 活用ライブラリー(分担執筆、乾賢一編)2009

    • Author(s)
      金井好克
    • Total Pages
      245
    • Publisher
      羊土社
  • [Book] Handbook of Experimental Pharmacology : TRP channels in health and disease

    • Author(s)
      Numata T, Kiyonaka S, et al.
    • Publisher
      Physiology Review(In press)
  • [Book] Bile Acid Biology and Therapeutic Actions

    • Author(s)
      Takada T, Suzuki H.
    • Publisher
      Springer(In press)
  • [Book] Molecular mechanisms of membrane transport of vitamin E.

    • Author(s)
      Takada T, Suzuki H.
    • Publisher
      Mol Nutr Food Res(In press)
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/pharmal/transportsome/top.html

  • [Patent(Industrial Property Rights)] 尿酸トランスポーター、並びに、尿酸輸送関連疾患素因及び炎症関連疾患素因の評価方法及び評価キット、検査体及び薬2009

    • Inventor(s)
      高田龍平, 鈴木洋史, 池淵祐樹, 伊藤晃成, 市田公美, 外
    • Industrial Property Number
      特願2009-148106
    • Acquisition Date
      2009-06-22

URL: 

Published: 2011-06-16   Modified: 2016-04-21  

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