Organic solute transportsomes: their molecular assembly and functional significance

2009 Fiscal Year Final Research Report

• Project/Area Number: 17081016
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University (2007-2009); Kyorin University (2005-2006)
• Principal Investigator: KANAI Yoshikatsu Osaka University, 医学系研究科, 教授 (60204533)
• Co-Investigator(Kenkyū-buntansha): NAGAMORI Shushi 大阪大学, 医学系研究科, 助教 (90467572) ; OHGAKI Ryuichi 大阪大学, 医学系研究科, 助教 (20467525) ; ANZAI Naohiko 杏林大学, 医学部, 講師 (70276054) ; HIRATA Taku 杏林大学, 医学部, 助教 (60372918) ; NATSUME Tohru 産業技術総合研究所, 生物情報解析研究センター, チームリーダー (00357683) ; KIMURA Tohru 杏林大学, 医学部, 助教 (30433725) ; UENO Takeshi 杏林大学, 医学部, 助教 (20406979)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Hidekazu 大阪大学, 医学系研究科, 助教 (70273638)
• Project Period (FY): 2005 – 2009
• Keywords: 膜輸送 / トランスポーター / 複合体 / 生体膜 / 上皮輸送

Research Abstract

The purpose of this research was to establish the idea of "transportsome". Toward its end, this research directed to demonstrate the molecular assembly corresponding to transportsome and to reveal its functional significance. This research has been completed by establishing the idea of "transportsome" by demonstrating the molecular assembly of the transportsomes formed by scaffold proteins and by reveling new types of transportsomes involving transporters and enzymes coupled by giving and taking the substrates and ones bridging membranes facing with each other.

Research Products

• [Journal Article] A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. (2010)
  • Author(s): Shiraya K, Hirata T, Hatano R, Nagamori S, Wiriyasermkul P, Jutabha P, Matsubara M, Muto S, Tanaka H, Asano S, Anzai N, Endou H, Yamada A, Sakurai H, Kanai Y
  • Journal Title: J Biol Chem. 285 Pages: 22141-22151
  • Peer Reviewed
• [Journal Article] L-type amino acid transporter 1 inhibitors inhibit tumor cell growth. (2010)
  • Author(s): Oda K, Hosoda N, Endo H, Saito K, Tsujihara K, Yamamura M, Sakata T, Anzai N, Wempe MF, Kanai Y, Endou H.
  • Journal Title: Cancer Sci. 101 Pages: 173-179
  • Peer Reviewed
• [Journal Article] Common Defects of ABCG2, a Highcapacity Urate Exporter, Cause Gout : A Function-based Genetic Analysis in a Japanese Population. (2009)
  • Author(s): Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Ikebuchi Y, Ito K, Kusanagi Y, Chiba T, Tadokoro S, Takada Y, Oikawa Y, Inoue H, Suzuki K, Okada R, Nishiyama J, Domoto H, Watanabe S, Fujita M, Morimoto Y, Naito M, Nishio K, Hishida A, Wakai K, Asai Y, Niwa K, Kamakura K, Nonoyama S, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Hamajima N, Shinomiya N.
  • Journal Title: Science Trans Med. 1 Pages: 41-48
  • Peer Reviewed
• [Journal Article] <18>^F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer. (2009)
  • Author(s): Kaira K, Oriuchi N, Shimizu K, Tominaga H, Yanagitani N, Sunaga N, Ishizuka T, Kanai Y, Mori M, Endo K.
  • Journal Title: J Nucl Med. 50 Pages: 1770-1776
  • Peer Reviewed
• [Journal Article] A pathogenic C terminus-truncated polycystin- 2 mutant enhances receptor-activated Ca^<2+> entry via association with TRPC3 and TRPC7 (2009)
  • Author(s): Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y.
  • Journal Title: J Biol Chem. 284 Pages: 34400-34412
  • Peer Reviewed
• [Journal Article] CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases. (2009)
  • Author(s): Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Kawashima O, Kamide Y, Ishizuka T, Kanai Y, Nakajima T, Mori M.
  • Journal Title: Ann Surg Oncol. 16(12) Pages: 3473-3481
  • Peer Reviewed
• [Journal Article] regulates the cellular localization and function of ABCB4. (2009)
  • Author(s): Ikebuchi Y, Takada T, Ito K, Yoshikado T, Anzai N, Kanai Y, Suzuki H.
  • Journal Title: Hepatol Res. 39 Pages: 1091-1097
  • Peer Reviewed
• [Journal Article] L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer. (2009)
  • Author(s): Imai H, Kaira K, Oriuchi N, Yanagitani N, Sunaga N, Ishizuka T, Kanai Y, Endou H, Nakajima T, Mori M.
  • Journal Title: Histopathology. 54(7) Pages: 804-813
  • Peer Reviewed
• [Journal Article] Sodium-dependent phosphate cotransporter type 1 (NPT1) sequence polymorphisms in male patients with gout. (2009)
  • Author(s): Urano W, Taniguchi A, Anzai N, Inoue E, Kanai Y, Yamanaka M, Kamatani N, Endou H, Yamanaka H.
  • Journal Title: Ann Rheum Dis.
  • Peer Reviewed
• [Journal Article] Amino acid transporter LAT3 is required for podocyte development and function. (2009)
  • Author(s): Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, Kurayama R, Higashihara E, Babu E, Kanai Y, Asanuma K, Nagata M, Majumdar A, Tryggvason K, Yan K.
  • Journal Title: J Am Soc Nephrol 20(7) Pages: 1586-1596
  • Peer Reviewed
• [Journal Article] L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas. (2009)
  • Author(s): Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Endou H, Nakajima T, Mori M
  • Journal Title: J Surg Oncol. 99(7) Pages: 433-438
  • Peer Reviewed
• [Journal Article] Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adeno- carcinoma. (2009)
  • Author(s): Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Nakajima T, Mori M.
  • Journal Title: Lung Cancer 66(1) Pages: 120-126
  • Peer Reviewed
• [Journal Article] Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer. (2009)
  • Author(s): Kaira K, Oriuchi N, Shimizu K, Ishikita T, Higuchi T, Imai H, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Endou H, Nakajima T, Endo K, Mori M.
  • Journal Title: Cancer Sci. 100(4) Pages: 753-758
  • Peer Reviewed
• [Journal Article] System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line. (2009)
  • Author(s): Yamauchi K, Sakurai H, Kimura T, Wiriyasermkul P, Nagamori S, Kanai Y, Kohno N.
  • Journal Title: Cancer Lett. 276(1) Pages: 95-101
  • Peer Reviewed
• [Journal Article] A novel role of the C-terminus of b^<0, +>AT in the ER-Golgi trafficking of the rBAT-b^<0, +>AT heterodimeric amino acid transporter. (2009)
  • Author(s): Sakamoto S, Chairoungdua A, Nagamori S, Wiriyasermkul P, Promchan K, Tanaka H, Kimura T, Ueda T, Fujimura M, Shigeta Y, Naya Y, Akakura K, Ito H, Endou H, Ichikawa T, Kanai Y.
  • Journal Title: Biochem J. 417 Pages: 441-448
  • Peer Reviewed
• [Journal Article] 栄養による個体機能制御と疾患 アミノ酸トランスポーターと癌 (2009)
  • Author(s): 金井好克
  • Journal Title: 細胞工学 28(8) Pages: 789-793
• [Journal Article] 上皮体制と病態 (2009)
  • Author(s): 金井好克
  • Journal Title: 腎臓 32 Pages: 139-146
• [Journal Article] Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. (2008)
  • Author(s): Matsuo H, Chiba T, Nagamori S, Nakayama A, Domoto H, Phetdee K, Wiriyasermkul P, Kikuchi Y, Oda T, Nishiyama J, Nakamura T, Morimoto Y, Kamakura K, Sakurai Y, Nonoyama S, Kanai Y, Shinomiya N.
  • Journal Title: Am J Hum Genet. 83 Pages: 744-751
  • Peer Reviewed
• [Journal Article] Fluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer : a clinicopathologic study. (2007)
  • Author(s): Kaira K, Oriuchi N, Otani Y, Shimizu K, Tanaka S, Imai H, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Dobashi K, Kanai Y, Endou H, Nakajima T, Endo K, Mori M.
  • Journal Title: Clin Cancer Res. 13 Pages: 6369-6378
  • Peer Reviewed
• [Journal Article] Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. (2007)
  • Author(s): Shin HJ, Anzai N, Enomoto A, He X, Kim do K, Endou H, Kanai Y.
  • Journal Title: Hepatology. Pages: 1046-1055
  • Peer Reviewed
• [Journal Article] The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity. (2006)
  • Author(s): Noshiro R, Anzai N, Sakata T, Miyazaki H, Terada T, Shin HJ, He X, Miura D, Inui K, Kanai Y, Endou H.
  • Journal Title: Kidney Int. Pages: 275-282
  • Peer Reviewed
• [Journal Article] A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter. (2006)
  • Author(s): Shigeta Y, Kanai Y, Chairoungdua A, Ahmed N, Sakamoto S, Matsuo H, Kim DK, Fujimura M, Anzai N, Mizoguchi K, Ueda T, Akakura K, Ichikawa T, Ito H, Endou H.
  • Journal Title: Kidney Int. Pages: 1198-1206
  • Peer Reviewed
• [Journal Article] Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins. (2005)
  • Author(s): Miyazaki H, Anzai N, Ekaratanawong S, Sakata T, Shin HJ, Jutabha P, Hirata T, He X, Nonoguchi H, Tomita K, Kanai Y, Endou H.
  • Journal Title: J Am Soc Nephrol. Pages: 3498-3506
  • Peer Reviewed
• [Presentation] 新規腎特異プロスタグランジントランスポーターOAT-PGの生理機能と代謝酵素15-hydroxyprostaglandin dehydrogenaseとの共役機構 (2010)
  • Author(s): 金井好克
  • Organizer: 脂質メディエーターワークショップ
  • Place of Presentation: 滋賀
  • Year and Date: 2010-12-19
• [Presentation] トランスポーター研究:辿ってきた道とこれから歩む道 (2010)
  • Author(s): 金井好克
  • Organizer: 日本薬学会第130年会20100329
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-29
• [Presentation] 有機溶質トランスポートソーム:その構築と機能的意義 (2010)
  • Author(s): 金井好克
  • Organizer: 特定領域研究公開シンポジウム「生体膜トランスポートソームの分子構築と生理機能」
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-19
• [Presentation] 癌特異的アミノ酸トランスポーターLAT1を介したPET リガンドL-[3-F]-α-methyltyrosine(FAMT)の輸送キネティクス (2010)
  • Author(s): 永森収志、金井好克, 他
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪府・大阪市
  • Year and Date: 2010-03-18
• [Presentation] シナプス接着部分でダイナミックな働きをする蛋白質の探索 (2010)
  • Author(s): 田中秀和、高藤和輝、施虹、永森収志、金井好克
  • Organizer: 日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-18
• [Presentation] LAT1ノックアウトマウスの表現型解析 (2010)
  • Author(s): 大垣隆一、 Yuewei Li、永森収志、金井好克
  • Organizer: 日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-16
• [Presentation] 腎皮質局所プロスタグランジンクリアランスにおける新規腎特異プロスタグランジントランスポーターの役割 (2010)
  • Author(s): 金井好克
  • Organizer: 第83回日本薬理学会年会シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-16
• [Presentation] 芳香族アミノ酸誘導体の抗腫瘍効果の確立 (2010)
  • Author(s): 金井好克
  • Organizer: 第11回未来医療交流会
  • Place of Presentation: 大阪
  • Year and Date: 2010-01-12
• [Presentation] アミノ酸トランスポーターの機能と病態-悪性腫瘍の診断と治療の分子標的としての可能性 (2009)
  • Author(s): 金井好克
  • Organizer: 第9回「アミノ酸セミナー」
  • Place of Presentation: 東京
  • Year and Date: 2009-12-18
• [Presentation] Metabolomics reveals in vivofunctions of transporters (2009)
  • Author(s): 金井好克
  • Organizer: 24^<th> JSSX AnnualMeeting in Kyoto
  • Place of Presentation: 京都
  • Year and Date: 2009-11-29
• [Presentation] メタボロミクスを用いた新規有機アニオントランスポーターOatn1の生体内における機能の解析 (2009)
  • Author(s): 永森収志、金井好克, 他
  • Organizer: 第116回日本薬理学会近畿部会
  • Place of Presentation: 滋賀県・大津市
  • Year and Date: 2009-11-13
• [Presentation] メタボロミクスによるトランスポーターの解析 (2009)
  • Author(s): 金井好克, 曽我朋義
  • Organizer: 第82回日本生化学会大会シンポジウム「メタボロミクスが切り拓くヒトシステム生物学」
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Amino acid transporters in cancer : relevance to its diagnosis and therapeutics (2009)
  • Author(s): 金井好克
  • Organizer: 19th International Congress of Nutrition (ICN) Satellite Symposium "Advanced Knowledges of Amino Acid Research in Human Health and Disease"
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2009-10-04
• [Presentation] トランスポーターと創薬 (2009)
  • Author(s): 金井好克
  • Organizer: 創薬薬理フォーラム 第17回シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-09-10
• [Presentation] Metabolomics approaches to orphan transporters (2009)
  • Author(s): 金井好克
  • Organizer: Biomedical Transporters 2009: Membrane transporters and impact on drug discover
  • Place of Presentation: Thun, Switzerland
  • Year and Date: 2009-08-12
• [Presentation] Novel organic anion transporters and new aspects of organic anion transport in renal proximal tubules (2009)
  • Author(s): Yoshikatsu Kanai
  • Organizer: 40th NIPS International Symposium-International Joint Symposium "Physiology of Anion Transport and Cell Volume Regulation (PAT- CVR 2009)"
  • Place of Presentation: 岡崎
  • Year and Date: 2009-08-06
• [Presentation] Transportsomes in Epithelial Function, XXXVIth International Union of Physiological Sciences.Satellite Symposium (2009)
  • Author(s): Yoshikatsu Kanai
  • Organizer: Ion Channels : function, structure, and physiology
  • Place of Presentation: 京都
  • Year and Date: 2009-08-04
• [Presentation] Characterization of an orphan transporter in SLC 7 family (2009)
  • Author(s): 永森収志、金井好克, 他
  • Organizer: The 36^<th> congress of International Union of Physiological Sciences
  • Place of Presentation: 京都府・京都市
  • Year and Date: 2009-07-31
• [Presentation] TRANSPORTSOME IN RENAL ORGANIC SOLUTE TRANSPORT、XXXVIth International Union of Physiological Sciences.Whole day symposium (2009)
  • Author(s): Yoshikatsu Kanai
  • Organizer: Epithelial transport : bridges between molecules andfunction
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] Stimulation of amino acids to growth signal in HEK293T (2009)
  • Author(s): 大垣隆一、 Narakorn Khunweeraphong, 永森収志, Taku Hirata, 金井好克
  • Organizer: The 36th International Congress of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] 腫瘍細胞型アミノ酸トランスポーターLAT1を介したPETリガンドL-[3-F]-α-methyltyrosine(FAMT)の輸送キネティクス (2009)
  • Author(s): 永森収志、金井好克, 他
  • Organizer: 第115回日本薬理学会近畿部会
  • Place of Presentation: 石川県・金沢市
  • Year and Date: 2009-06-26
• [Presentation] Substraterecognition of L-type amino acidtransporter 1, LAT1, and transportkinetics of its PET ligandL-[3-F]-α-methyltyrosine (2009)
  • Author(s): 永森収志、金井好克, 他
  • Organizer: FAMT、GordonResearch Conference : Mechanisms OfMembrane Transport
  • Place of Presentation: 米国・メイン州ウオータービル
  • Year and Date: 2009-06-15
• [Presentation] アミノ酸トランスポーター:悪性腫瘍の診断と治療の分子標的としての可能性 (2009)
  • Author(s): 金井好克
  • Organizer: 第2回Bimonthly symposiumトランスポーターシンポジウム「トランスポーター研究の新たな展開-トランスポーターを標的とした創薬への動向-」20090602
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-02
• [Presentation] アミノ酸トランスポーターと細胞機能 (2009)
  • Author(s): 金井好克
  • Organizer: 第63回日本栄養\食糧学会大会 シンポジウム「アミノ酸の新しい機能とこれからの展開」
  • Place of Presentation: 長崎
  • Year and Date: 2009-05-22
• [Presentation] Transportsomes in cellularfunction. (2009)
  • Author(s): 金井好克
  • Organizer: 特定領域研究「膜輸送複合体」平成20年度公開シンポジウム
  • Place of Presentation: 京都市
  • Year and Date: 2009-01-28
• [Presentation] New aspects of organic anion transport in renal tubular epithelia. (2009)
  • Author(s): 金井好克
  • Organizer: 2009 IUPS International Conference of Physiological Sciences
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-01-16
• [Presentation] メタボロミクスによるトランスポーターの生体内機能の解明 (2008)
  • Author(s): 金井好克
  • Organizer: BMB2008
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-11
• [Presentation] トランスポーターの生体内機能の理解に向けて-メタボロミクス技術がトランスポーター研究にもたらすもの- (2008)
  • Author(s): 金井好克
  • Organizer: トランスポーターワークショップ
  • Place of Presentation: 鶴岡市
  • Year and Date: 2008-11-15
• [Presentation] Prostalandin (PG)輸送体OAT-PG/Prostaglandin代謝酵素15-PGDH分子複合体の腎皮質局所PGE2クリアランスにおける役割 (2008)
  • Author(s): 波多野亮、金井好克
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-11-14
• [Presentation] メタボロミクスによるトランスポーター機能の解析 (2008)
  • Author(s): 金井好克
  • Organizer: トランスポーターワークショップ
  • Place of Presentation: 鶴岡市
  • Year and Date: 2008-10-31
• [Presentation] アミノ酸輸送と細胞機能 (2008)
  • Author(s): 金井好克
  • Organizer: アミノ酸学会第2回夏のシンポジウム
  • Place of Presentation: 松山市
  • Year and Date: 2008-08-31
• [Presentation] C.elegans amino acid transporter-6 (AAT-6), which does not possess a conserved cysteine, requires non-SS interaction with glyco-protein ATG-1 for the function.Gordon Research Conference Membrane Transport. (2008)
  • Author(s): 永森収志、金井好克
  • Organizer: Gordon Research Conference Membrane Transport
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2008-07-22
• [Presentation] 有機アニオントランスポーター:腎尿細管上皮輸送における新たな展開 (2007)
  • Author(s): 金井好克, 安西尚彦, 平田拓, 木村徹, 上野剛, 福冨俊之
  • Organizer: 第84回日本生理学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-22
• [Presentation] Post-genome perspective of SLC22 drug transporter family : metabolomics, polymorphism and transportsome.The 4th International Sympsium on Pharmacogenomics (2007)
  • Author(s): 金井好克
  • Organizer: Step Toward Personalized Medicine, Soul
  • Year and Date: 2007-03-09
• [Presentation] Seminar ‘Interaction of organic anion transporters with PDZ proteins' (2007)
  • Author(s): 金井好克
  • Organizer: The 10^<th> Membrane Research Forum
  • Place of Presentation: Kyoto
  • Year and Date: 2007-02-28
• [Presentation] シンポジウムII「通風と核酸代謝のトピックス」尿酸と有機アニオンのトランスポーター:最近の進展 (2007)
  • Author(s): 金井好克
  • Organizer: 第40回日本通風\核酸代謝学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-02-15
• [Presentation] Symposium 1 ‘Heterodimeric amino acid transporters : protein-protein interactions for membrane targeting and cellular signaling' (2007)
  • Author(s): 金井好克
  • Organizer: Joint International Symposiu Membran Transport as a Universal Biological Mechanism Program
  • Year and Date: 2007-01-13
• [Presentation] 特別講演「特定領域トランスポートソーム」 (2006)
  • Author(s): 金井好克
  • Organizer: 第1回トランスポーター研究会
  • Place of Presentation: 東京
  • Year and Date: 2006-12-16
• [Presentation] Intracellular signaling mediated by amino acid transporter/CD98 complex. (2006)
  • Author(s): 金井好克
  • Organizer: The 18^<th> Japan-Korea Joint Seminar on Pharmacology
  • Place of Presentation: Kobe
  • Year and Date: 2006-09-23
• [Presentation] Workshop 7; Hetrodimeric amino acid transporters : molecular biology and pathological and pharmacological relevance. (2006)
  • Author(s): 金井好克
  • Organizer: The 12^<th> International Federation of Placenta Associations Meeting
  • Place of Presentation: Kobe
  • Year and Date: 2006-09-07
• [Presentation] 教育講演「イオン輸送と輸送体\最近の知見」 (2006)
  • Author(s): 金井好克
  • Organizer: 平成18年度社団法人日本腎臓学会定例会
  • Place of Presentation: Kobe
  • Year and Date: 2006-06-14
• [Presentation] シンポジウム薬効・副作用を支配する薬物トランスポーターSLC22有機アニオントランスポーターの最近の進展 (2006)
  • Author(s): 金井好克
  • Organizer: 第79回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2006-03-08
• [Presentation] Transporters of pharmacogenomics : Recent advances in the molecular identification of SLC22 organic anion transporters. (2006)
  • Author(s): 金井好克
  • Organizer: Pharmacogenomics : A Step Toward Personalized Medicine
  • Place of Presentation: Busan, Korea
  • Year and Date: 2006-02-17
• [Presentation] アミノ酸トランスポーター (2005)
  • Author(s): 金井好克
  • Organizer: 第2回インビトロジェン\シンポジウム「バイオサイエンスの最先端」
  • Place of Presentation: 湘南
  • Year and Date: 20050901-20050903
• [Presentation] 尿酸トランスポーターの薬理￠薬物トランスポーター:最新の治験と今後の方向性￡ (2005)
  • Author(s): 金井好克
  • Organizer: 第26回日本臨床薬理学年会
  • Place of Presentation: 別府
  • Year and Date: 2005-12-03
• [Presentation] Amino Acid Transporters : Cancer target discovery. (2005)
  • Author(s): 金井好克
  • Organizer: 13^<th> NA ISSX MEETING/20^<th> JSSX MEETING
  • Place of Presentation: Maui, U.S.A.
  • Year and Date: 2005-10-26
• [Presentation] アミノ酸トランスポーター抑制よる抗腫瘍効果の検討 (2005)
  • Author(s): 金井好克, 安西尚彦, Chairoungdua A, 遠藤仁
  • Organizer: 第64回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2005-09-15
• [Book] Annual Review腎臓(「腎尿細管におけるMg^<2+>輸送」)(分担執筆) (2009)
  • Author(s): 金井好克
  • Total Pages: 35-42
  • Publisher: 中外医学社
• [Book] 遺伝子医学MOOK(最新トランスポーター研究)(編集、分担執筆)(12号) (2009)
  • Author(s): 金井好克
  • Total Pages: 29-34,68-75
• [Book] トランスポーター科学最前線(アミノ酸トランスポーター:過去、現在、そして未来へ)(分担執筆) (2008)
  • Author(s): 金井好克
  • Total Pages: 223-244
  • Publisher: 京都廣川書店
• [Remarks] ホームページ
  • URL: http://www.med.osaka-u.ac.jp/pub/pharma1/transportsome/top.html