2009 Fiscal Year Final Research Report
Molecular mechanism of brain layer formation regulated by Reelin
| Project/Area Number |
17082007
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nagoya City University |
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Principal Investigator |
HATTORI Mitsuharu Nagoya City University, 大学院・薬学研究科, 教授 (60272481)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 脳 / タンパク質 / 遺伝子 / プロテアーゼ / 神経細胞 / 精神神経疾患 |
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| Research Abstract |
Reelin is essential for brain layer formation, but its exact function and underlying mechanism are nor well understood. We found that the C-terminal region of Reelin plays important roles in the interaction between this protein and neuronal cell membrane. We identified the protease in charge of specific proteolysis of Reelin. We also investigated when and where Reelin is received in the developing brain and found that Reelin acts on pre/early migratory neurons,
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[Journal Article] Mechanism and significance of specific proteolytic cleavage of Reelin.2009
Author(s)
Kohno, S., Kohno, T., Nakano, Y., Suzuki, K., Ishii, M., Tagami, H., Baba, A., Hattori, M
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Journal Title
Biochem. Biophys. Res. Commun 380
Pages: 93-97
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[Journal Article] Fyn tyrosine kinase regulates the surface expression of GPI-linked ephrin via the modulation of sphingomyelin metabolism.2009
Author(s)
Baba, A., Akagi, K., Takayanagi, M., Flanagan, J., Kobayashi, T., Hattori, M.
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Journal Title
J. Biol. Chem. 284
Pages: 9206-9214
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[Journal Article] C-terminal region-dependent change of antibody-binding to the eighth Reelin repeat reflects the signaling activity of Reelin.2009
Author(s)
Kohno, T., Nakano, Y., Kitoh, N., Yagi, H., Kato, K., Baba, A., Hattori, M.
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Journal Title
J. Neurosci. Res. 87
Pages: 3043-3053
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[Journal Article] Downregulation of functional Reelin receptors in projection neurons implys that primary Reelin action occurs at early/pre-migratory stages.2009
Author(s)
Uchida, T., Baba, A., Perez-Martinez, F.J., Hibi, T., Miyata, T., Luque, J.M., Nakajima, K., Hattori, M.
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Journal Title
J. Neurosci 29
Pages: 10653-10662
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[Journal Article] Novel affinity tag system using structurally defined antibody-tag interaction: application to single-step protein purification.2008
Author(s)
Nogi, T., Sangawa, T., Tabata, S., Nagae, M., Tamura-Kawakami, K., Beppu, A., Hattori, M., Yasui, N., Takagi, J.
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Journal Title
Protein Sci. 17
Pages: 2120-2126
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[Journal Article] Structure of a receptor-binding fragment of Reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors.2007
Author(s)
Yasui, N., Nogi, T., Kitao, T., Nakano, Y., Hattori, M., Takagi, J.
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Journal Title
Proc. Natl. Acad. Sci. U.S.A. 104
Pages: 9988-9993
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[Journal Article] The extremely conserved C-terminal region of Reelin is not necessary for secretion but is required for efficient activation of downstream signaling.2007
Author(s)
Nakano, Y., Kohno, T., Hibi, T., Kohno, S., Baba, A., Mikoshiba, K., Nakajima, K., Hattori, M.
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Journal Title
J. Biol. Chem. 282
Pages: 20544-20552
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