Roles of Notch localization to adherens junctions in Notch signaling

2009 Fiscal Year Final Research Report

• Project/Area Number: 17082009
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo University of Science
• Principal Investigator: MATSUNO Kenji Tokyo University of Science, 基礎工学部, 教授 (60318227)
• Co-Investigator(Renkei-kenkyūsha): 前田 礼男 東京理科大学, 基礎工学部, 助教 (40453831) ; 奥村 高志 東京理科大学, 基礎工学部, ポストドクトラル研究員 (20449234)
• Project Period (FY): 2005 – 2009
• Keywords: Notch / adherens junctions / エンドサイトーシス / エキソサイトーシス / 上皮細胞 / 細胞極性 / O-フコシル化 / ショウジョウバエ

Research Abstract

Notch (N) signaling regulates cell-specifications through cell-cell interactions. N andits ligands localize to the adherence junctions (AJs) in epithelial cells. We identifiedgenes required for the localization of N to AJs.

Research Products

• [Journal Article] Left-right asymmetric morphogenesis of the anterior midgut depends on the activation of a non-muscle myosin II in Drosophila. (2010)
  • Author(s): Okumura, T., Fujiwara, H., Taniguchi, K., Kuroda, J., Nakazawa, N., Nakamura, N., Hatori, R., Ishio, A., Maeda, R., Matsuno, K.
  • Journal Title: Dev. Biol (in press)
  • Peer Reviewed
• [Journal Article] Two pathways for importing GDP-fucose into the ER lumen function redundantly in the O-fucosylation of Notch in Drosophila. (2010)
  • Author(s): Ishikawa, H., Ayukawa, T., Nakayama, N., Higashi, S., Kamiyama, S., Nishihara, S., Aoki, K., Ishida, N., Sanai, Y., Matsuno, K
  • Journal Title: J. Biol. Chem. 285 Pages: 4122-4129
  • Peer Reviewed
• [Journal Article] The development and evolution of left-right asymmetry in invertebrates: lessons from Drosophila and snails. (2008)
  • Author(s): Okumura, T., Utsuno, H., Kuroda, J., Gittenberger, E., Asami, T., Matsuno, K.
  • Journal Title: Dev. Dyn 237 Pages: 3497-3515
  • Peer Reviewed
• [Journal Article] The head region of unconventional Myosin I family members is responsible for the organ-specificity of their roles in left-right polarity in Drosophila. (2008)
  • Author(s): Hozumi, S., Maeda, R., Taniguchi-Kanai, M., Okumura, T., Taniguchi, K., Kawakatsu, Y., Nakazawa, N., Hatori, R., Matsuno, K
  • Journal Title: Dev. Dyn. 237 Pages: 3528-3537
  • Peer Reviewed
• [Journal Article] Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of Notch in the endosomal trafficking pathway. (2008)
  • Author(s): Wilkin, M.B., Tongngok, P., Gensch, N., Clemence, S., Motoki, M., Yamada, K., Hori, K., Taniguchi-Kanai, M., Franklin, E., Matsuno, K., Baron, M
  • Journal Title: Dev. Cell 15 Pages: 762-772
  • Peer Reviewed
• [Journal Article] Distinct activation patterns of EGF receptor signaling in the homoplastic evolution of eggshell morphology in genus Drosophila. (2008)
  • Author(s): Kagesawa, T., Nakamura, Y., Nishikawa, M., Akiyama, Y., Kajiwara, M., Matsuno, K.
  • Journal Title: Mech. Dev 125 Pages: 1020-1032
  • Peer Reviewed
• [Journal Article] The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila. (2007)
  • Author(s): Sasamura, T., Ishikawa, H.O., Sasaki, N., Higashi, S., Kanai, M., Nakao, S., Ayukawa, T., Aigaki, T., Noda, K., Miyoshi, E., Taniguchi, N., Matsuno, K.
  • Journal Title: Development 134 Pages: 1347-1356
  • Peer Reviewed
• [Journal Article] Soma-dependent modulations contribute to divergence of rhomboid expression during evolution of Drosophila eggshell morphology. (2007)
  • Author(s): Nakamura, Y., Kagesawa, T., Nishikawa, M., Hayashi, Y., Kobayashi, S., Niimi, T., Matsuno, K.
  • Journal Title: Development 134 Pages: 1529-1537
  • Peer Reviewed
• [Journal Article] Roles of type I Myosins in Drosophila handedness. (2007)
  • Author(s): Taniguchi, K., Hozumi, S., Maeda, R., Okumura, T., Matsuno, K
  • Journal Title: Fly 1 Pages: 287-290
  • Peer Reviewed
• [Journal Article] D-JNK signaling in visceral muscle cells controls the laterality of the Drosophila gut. (2007)
  • Author(s): Taniguchi, K., Hozumi, S., Maeda, R., Ooike, M., Sasamura, T., Aigaki, T., Matsuno, K
  • Journal Title: Dev. Biol. 311 Pages: 251-263
  • Peer Reviewed
• [Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. (2007)
  • Author(s): Oyama, T., Harigaya, K., Muradil, A., Hozumi, K., Habu, S., Oguro, H., Iwama, A., Matsuno, K., Sakamoto, R., Sato M., Yoshida, N., Kitagawa, M.
  • Journal Title: Proc. Natl. Acad. Sci. USA 104 Pages: 9764-9769
  • Peer Reviewed
• [Journal Article] The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. (2007)
  • Author(s): Araki, Y., Kawano, T., Taru, H., Saito, Y., Wada, S., Miyamoto, K., Kobayashi, H., Ishikawa, H.O., Ohsugi, Y., Yamamoto, T., Matsuno, K., Kinjo, M. Suzuki, T
  • Journal Title: EMBO J 26 Pages: 1475-1486
  • Peer Reviewed
• [Journal Article] Roles of single-minded in the left-right asymmetric development and tissue specifications of the Drosophila embryonic gut. (2007)
  • Author(s): Maeda, R., Hozumi, S., Taniguchi, K., Sasamura, T., Murakami, R., Matsuno, K
  • Journal Title: Mech. Dev. 124 Pages: 204-217
  • Peer Reviewed
• [Journal Article] Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells. (2007)
  • Author(s): Sasaki N., Sasamura, T., Ishikawa, H.O., Kanai, M., Ueda, R., Saigo, K., Aigaki, T., Matsuno K. Polarized
  • Journal Title: Genes to Cells 12 Pages: 89-103
  • Peer Reviewed
• [Journal Article] A Drosophila unconventional myosin reverses the default handedness in visceral organs. (2006)
  • Author(s): Hozumi, S., Maeda, R., Taniguchi, K., Sasamura, T., Speder, P., Noselli, S., Aigaki, T., Murakami, R., Matsuno, K
  • Journal Title: Nature 440 Pages: 798-802
  • Peer Reviewed
• [Journal Article] The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. (2006)
  • Author(s): Fuwa, T.J., Hori, K., Sasamura, T., Higgs, J., Baron, M., Matsuno, K
  • Journal Title: Mol. Genet. and Genom 275 Pages: 251-263
  • Peer Reviewed
• [Journal Article] Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc. (2005)
  • Author(s): Ishikawa, H.O., Higashi, S., Ayukawa, T., Sasamura, T., Aoki, K., Ishida N., Sanai, Y., Matsuno, K
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 18532-18537
  • Peer Reviewed
• [Journal Article] Genetic regions interacting with loss- and gain-of-function phenotypes of deltex implicate novel genes involved in Drosophila Notch signaling. (2005)
  • Author(s): Hori, K., Fuwa, J.T., Seki, T., Matsuno, K
  • Journal Title: Mol. Genet. and Genom 272 Pages: 627-638
  • Peer Reviewed
• [Presentation] A RNAi screen to identify the genes regulating vesicular trafficking of Notch in Drosophila (2009)
  • Author(s): Naoki Aoyama, Ikuo Tamura, Keita Koyama, Tadaaki Katsuda, Kenji Matsuno
  • Organizer: The Notch Meeting 2009
  • Place of Presentation: ギリシャ
  • Year and Date: 20090928-20091001
• [Presentation] 選択的エンドサイトーシスを介したNotch下流シグナルの二分岐機構の研究 (2009)
  • Author(s): Kenta Yamada, Kazuya Hori, Kenji Matsuno
  • Organizer: 42st Annual Meeting of JSDB
  • Place of Presentation: 新潟
  • Year and Date: 20090528,20090530
• [Presentation] A Novel role of Notch monosaccharide O-fucose modification is required for Delta-Notch but not Serrate-Notch signaling in Drosophila. (2009)
  • Author(s): Tomonori Ayukawa, Hiroyuki Ishikawa, Minoru Nakayama, Shin Kamiyama, Shoko Nishihara, Tetsuya Okajima, Kazuhisa Aoki, Nobuhiro Ishida, Yutaka Sanai, Kenji Matsuno
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: シカゴ
  • Year and Date: 20090305-20090307
• [Presentation] RNA干渉法を用いたショウジョウバエNotchの細胞内小胞輸送に関する遺伝子の網羅的探索 (2009)
  • Author(s): 青山尚規, 田村郁雄, 小山啓太, 勝田江朗, 上田龍, 山口(武井)ゆき, 渡辺晃, 北田裕介, 多羽田哲也, 松野健治
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] 小胞体形成に必須な新規因子PecanexのNotch情報伝達における機能の解析 (2009)
  • Author(s): 山川智子, 笹村剛司, 金井麻衣子, Mark E。Fortini, 松野健治
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Deltex Promotes endoctic transport of Notch to lysosome-related organelles that are alternative compartments for Notch activation. (2009)
  • Author(s): 山田健太, Marian Wilkin, Martin Baron, 松野健治
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Roles of O-fucosyltransferase1 in the trafficking and activation of Notch in Drosophila (2009)
  • Author(s): Kenji Matsuno
  • Organizer: The Notch Meeting 2009
  • Place of Presentation: ギリシャ
  • Year and Date: 2009-10-01
• [Presentation] A novel role of Notch monosaccharide O-fucose modification is required for Delta-Notch but not Serrate-Notch signaling in Drosophila (2009)
  • Author(s): Tomonori Ayukawa, Hiroyuki O. Ishikawa, Shunsuke Higashi, Tetsuya Okajima, Kenji Mtasuno
  • Organizer: The 9th Japanese Drosophila Resarch Conference
  • Place of Presentation: 静岡
  • Year and Date: 2009-07-07
• [Presentation] Matsuno Functions of a neurogenic gene, pecanex in Notch signaling (2009)
  • Author(s): Tomoko Yamakawa, Takeshi Sasamura, Maiko Kanai, Mark E. Fortini, Kenji
  • Organizer: The 9th Japanese Drosophila Resarch Conference
  • Place of Presentation: 静岡
  • Year and Date: 2009-07-07
• [Presentation] A genome-wide RNAi screen to identify the genes regulating vesicular trafficking of Notch in Drosophila melanogaster (2009)
  • Author(s): Naoki Aoyama, Ikuo Tamura, Koyama Keita, Ryu Ueda, Yuki Yamaguchi-Takei, Akira Watanabe, Yusuke Kitada, Tetsuya Tabata, Kenji Matsuno
  • Organizer: The 9th Japanese Drosophila Resarch Conference
  • Place of Presentation: 静岡
  • Year and Date: 2009-07-06
• [Presentation] ショウジョウバエ生体内におけるRNAiを用いたNotchの小胞輸送因子の遺伝学的探索 (2009)
  • Author(s): Naoki Aoyama, Hiroyuki Okubo, Mki Ohhri, Ikuo Tamura, Eriko Iida, Ryu Ueda, Yuki Yamaguchi-Takei, Akira Watanabe, Yusuke Kitada, Kenji Matsuno
  • Organizer: 42st Annual Meeting of JSDB
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-30
• [Presentation] 機能未知のneurogenic遺伝子pecanexのNotchシグナルにおける機能 (2009)
  • Author(s): Tomoko Yamakawa, Takeshi Sasamura, Maiko Kanai, Mark E Fortini, Kenji Matsuno
  • Organizer: 42st Annual Meeting of JSDB
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-29
• [Presentation] A novel role of Notch monosaccharide O-fucose modification is required for Delta-Notch but not Serrate-Notch signaling in Drosophila. (2009)
  • Author(s): Tomonori Ayukawa, Hiroyuki Ishikawa, Minoru Nakayama, Shunsuke Higashi, Shin Kamiyama, Shoko Nishihara, Tetsuya Okajima, Kazuhisa Aoki, Nobuhiro Ishida, Yutaka Sanai, Kenji Matsuno
  • Organizer: 42st Annual Meeting of JSDB
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-29
• [Presentation] Downstream signaling of the Notch receptor diverges into two distinct pathways via its selective endocytic trafficking mediated by Deltex (2008)
  • Author(s): Kenta Yamada, Kazuya Hori, Takashi J Fuwa, Kenji Matsuno
  • Organizer: 41st Annual Meeting of JSDB
  • Place of Presentation: 徳島
  • Year and Date: 20080528-20080529
• [Presentation] Functions of a neurogenic gene, pecanex in Notch signaling (2008)
  • Author(s): Tomoko Yamakawa, Takeshi Sasamura, Maiko Kanai, Kenji Matsuno
  • Organizer: 41st Annual Meeting of JSDB
  • Place of Presentation: 徳島
  • Year and Date: 20080528-20080529
• [Presentation] Two GFP-fucose transporters, one localizes to endoplasmic reticulum(ER)and the other to Golgi, have redundant roles for the O-fucosylation of Notch (2008)
  • Author(s): Tomonori Ayukawa, Hiroyuki Ishikawa, Nobuhiro Ishida, Kazuhisa Aoki, Yutaka Sanai, Shin Kamiyama, Syoko Nishihara, Kenji Matsuno
  • Organizer: 41st Annual Meeting of JSDB
  • Place of Presentation: 徳島
  • Year and Date: 20080528-20080529
• [Presentation] Matsuno Fucose modification is essential for Delte-but not Serrate-dependent activation of Notch signaling in Drosophila (2008)
  • Author(s): Tomonori Ayukawa, Hiroyuki O Ishikawa, Kenji Matsuno
  • Organizer: 49th Annual Drosophila Research Conference
  • Place of Presentation: サンディエゴ
  • Year and Date: 20080402-20080406
• [Presentation] Roles of Drosophila Deltex in Suppressor of Hairless-independent Notch signaling. (2008)
  • Author(s): Kenta Yamada, Kazuya Hori, Takashi J Fuwa, Kenji Matsuno
  • Organizer: 49th Annual Drosophila Research Conference
  • Place of Presentation: サンディエゴ
  • Year and Date: 20080402-20080406
• [Presentation] Downstream signal of the Notch receptor diverges into two distinct pathways through its selective endocytic trafficking mediated by Deltex (2008)
  • Author(s): Kenta Yamada, Kazuya Hori, Takashi J Fuwa, Kenji Matsuno
  • Organizer: BMB2008第31回日本分子生物学会年会 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Functions of a neurogenic gene, pecanex in Notch signaling (2008)
  • Author(s): Tomoko Yamakawa, Takeshi Sasamura, Maiko Kanai, Kenji Matsuno
  • Organizer: BMB2008第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] A genome-wide RNAi screen to indetify the genes regulating vesicular trafficking of Notch in Drosophila melanogaster (2008)
  • Author(s): Naoki Aoyama, Hiroyuki Okubo, Maki Ohhori, Ikuo Tamura, Eriko Iida, Ryu Ueda, Yuki Yamaguchi-Takei, Akira Watanabe, Yusuke Kitada, Tetsuya Tabata, Kenji Matsuno
  • Organizer: 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] A novel role of Notch monosaccharide O-fucose modification is required for Delta-Notch but not Serrate-Notch signaling in Drosophila (2008)
  • Author(s): Tomonori Ayukawa, Hiroyui Ishikawa, Minoru Nakayama, Shunsuke Higashi, Shin Kamiyama, Shoko Nishihara, Tetsuya Okajima, Nobuhiro Ishida, Kazuhisa Aoki, Yutaka Sanai, Kenji Matsuno
  • Organizer: 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] ショウジョウバエNotchのO-フコース修飾はDI-Notchに依存するシグナルの活性化には必要だがSer-Notchシグナルに依存するシグナルの活性化は必要ない (2007)
  • Author(s): 鮎川友紀, 石川裕之, 松野健治
  • Organizer: BMB2007弟30回日本分子生物学会年会第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] ショウジョウバエNotchの細胞内小胞輸送を制御する遺伝子の検索 (2007)
  • Author(s): 吉田裕果, 大堀真紀, 大久保洋之, 田村郁雄, 多羽田哲也, 山口(武井)ゆき, 渡辺晃, 北田祐介, 上田龍, 松野健治
  • Organizer: BMB2007弟30回日本分子生物学会年会第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila. (2007)
  • Author(s): Kenji Matsuno, Takeshi Sasamura, Hiroyuki Ishikawa, Nobuo Sasaki, Tomonori Ayukawa, Kenta Yamada, Tomoko Yamakawa
  • Organizer: 48th Annual Drosophila Resarch Conference
  • Place of Presentation: フィラデルフィア
  • Year and Date: 2007-03-09
• [Presentation] Epithelial Notch localizes to subapical complex and adherens junctions by polarized exocytosis and Dynamin-dependent transcytosis (2006)
  • Author(s): Nobuo Sasaki, Takeshi Sasamura, Hiroyuki O. Ishikawa, Maiko Kanai, Kenji Matsuno
  • Organizer: 47th Annual Drosophila Research Conference
  • Place of Presentation: ヒューストン
  • Year and Date: 2006-03-29
• [Book] 実験医学 (2009)
  • Author(s): 山田健太, 山川智子, Martin Baron, 松野健治
  • Total Pages: 1251-1254
• [Book] サイエンスネット (2008)
  • Author(s): 松野健治
  • Publisher: 数研出版
• [Book] 細胞工学 (2008)
  • Author(s): 奥村高志, 川勝康弘, 谷口喜一郎, 松野健治
  • Total Pages: 553-557
• [Book] 生化学 (2007)
  • Author(s): 前田礼男, 穂積俊矢, 谷口喜一郎, 奥村高志, 松野健治
  • Total Pages: 1131-1134
• [Book] 蛋白質核酸酵素 (2007)
  • Author(s): 穂積俊矢, 前田礼男, 谷口喜一郎, 松野健治
  • Total Pages: 227-235
• [Book] 蛋白質核酸酵素 (2007)
  • Author(s): 中越英樹, 松野健治
  • Total Pages: 119-125
• [Book] LABIO21 (2007)
  • Author(s): 谷口喜一郎, 穂積俊矢, 前田礼男, 松野健治
  • Total Pages: 22-26
• [Book] 細胞工学 (2006)
  • Author(s): 穂積俊矢, 前田礼男, 谷口喜一郎, 松野健治
  • Total Pages: 642-643
• [Book] Bionics (2006)
  • Author(s): 前田礼男, 穂積俊矢, 谷口喜一郎, 松野健治
  • Total Pages: 70-71
• [Book] Functional Glycomics (2006)
  • Author(s): 石川裕之, 松野健治
  • Total Pages: 58-65
• [Book] 糖鎖と病気 (2005)
  • Author(s): 石川裕之, 笹村剛司, 鮎川友紀, 松野健治
  • Total Pages: 144-149
• [Remarks]
  • URL: http://matsuno-lab.homeip.net/frame.html