2009 Fiscal Year Final Research Report
Magnetic approaches to bioimaging and functional brain dynamics
| Project/Area Number |
17100006
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyushu University (2006-2009)
The University of Tokyo (2005) |
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Principal Investigator |
UENO Shoogo Kyushu University, 大学院・工学研究院, 特任教授 (00037988)
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| Co-Investigator(Kenkyū-buntansha) |
IRAMINA Keiji 九州大学, 大学院・システム情報科学研究院, 教授 (20211758)
SEKINO Masaki 東京大学, 大学院・新領域創成科学研究科, 助教 (20401036)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 生体磁気 / 電流分布MRI / 経頭蓋磁気刺激 / 誘導電流シミュレーション / フェリチン / 磁気ナノ粒子 |
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| Research Abstract |
In this study, a new method to detect weak magnetic fields arising from neuronal electrical activities using magnetic-resonance imaging (MRI) was developed to investigate the dynamics of brain function. Using this technique, it was possible to image neuronal activities in the rat brain by MRI. An imaging technique, which combines the transcranial magnetic stimulation and EEG measurement simultaneously, enabled us to estimate brain function with high spatial and temporal resolutions. The interaction of radio-frequency (RF) magnetic fields with iron cage proteins and the alteration of their functioning were investigated to observe the accumulation of amyloid by MRI.
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[Journal Article] Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging.2007
Author(s)
Kumagai M, Imai Y, Nakamura T, Yamasaki Y, Sekino M, Ueno S, Hanaoka K, Kikuchi K, Nagano T, Kaneko E, Shimokado K, Kataoka K.
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Journal Title
Colloids and Surfaces B: Biointerfaces 56
Pages: 174-181
Peer Reviewed
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