2009 Fiscal Year Final Research Report
Regulation and interaction of SOX family transcription factors as the basis of neural primordial development
| Project/Area Number |
17107005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Osaka University |
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Principal Investigator |
KONDOH Hisato Osaka University, 大学院・生命機能研究科, 教授 (70127083)
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| Co-Investigator(Kenkyū-buntansha) |
KAMACHI Yusuke 大阪大学, 大学院・生命機能研究科, 准教授 (90263334)
UCHIKAWA Masanori 大阪大学, 大学院・生命機能研究科, 助教 (80346147)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEMOTO Tatsuya 大阪大学, 大学院・生命機能研究科, 助教 (30443899)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 遺伝子 / シグナル伝達 / 脳・神経 / 発現制御 / 発生・分化 |
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| Research Abstract |
The neural plate, or the embryonic neural primordium, is the first somatic tissue to develop in vertebrate embryos. Although its development is marked by Sox2 gene activation regardless of the tissue domain, the Sox2 gene itself is regulated by different enhancers of distinct domain specificities. Investigation of this domain-specific regulation indicated that the anterior, medial and posterior portions of the neural plate are individually derived from the epiblast through distinct regulatory mechanisms. Of particular note is that the posterior neural plate arises from a common precursor shared by the paraxial mesoderm, which is a derivative of the posterior epiblast. This fact rules out a classical model that describes the neural primordium as being induced from the ectoderm after its separation from the mesoderm. Further results indicated that SOX2 interacts with POU factors to regulate many genes involved in promoting neural plate development.
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Research Products
(21 results)
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[Journal Article] nt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord.2009
Author(s)
Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang CW, Oginuma M, Saga Y, Behringer RR, Kondoh H, Sasaki H.
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Journal Title
Mech Dev. 126
Pages: 791-803
Peer Reviewed
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