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2009 Fiscal Year Final Research Report

Molecular Mechanisms of Vertebrate Photoperiodism

Research Project

  • PDF
Project/Area Number 17108003
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionNagoya University

Principal Investigator

EBIHARA Shizufumi  Nagoya University, 生命農学研究科, 教授 (50135331)

Co-Investigator(Kenkyū-buntansha) MAEDA Keiichirou  名古屋大学, 大学院・生命農学研究科, 教授 (30181580)
YOSHIMURA Takashi  名古屋大学, 大学院・生命農学研究科, 教授 (40291413)
IIGO Masayuki  宇都宮大学, 農学部, 准教授 (10232109)
Co-Investigator(Renkei-kenkyūsha) NAKAO Nobuhiro  名古屋大学, 大学院・生命農学研究科, 研究員
HW Korf  Johann Wofgang Goethe-Universitat, 教授
YASUO Shinobu  Johann Wofgang Goethe-Universitat, 研究員
Project Period (FY) 2005 – 2009
Keywords生理 / 行動 / 生産機能制御
Research Abstract

The photoperiodic control of physiological phenomena (known as photoperiodism), such as flowering in plants and reproductive activity in animals is observed in a wide variety of species. However, the molecular mechanism of photoperiodism was not well understood in any organism studies. In the present study, we investigated a process from photic inputs to GnRH release in photoperiodism, focusing on the regulation and function of Dio2 gene using fish, birds and mammals.

  • Research Products

    (35 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (10 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A mammalian neural tissue opsin(Opsin 5)is a deep brain photoreceptor in birds.2010

    • Author(s)
      Nakane Y, Ebihara S, Yoshimura T.
    • Journal Title

      Proc Natl Acad Sci USA. 107(34)

      Pages: 15264-15268

    • Peer Reviewed
  • [Journal Article] Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests.2009

    • Author(s)
      Tomida S, Mamiya T, Abe K, Yoshimura T, Nabeshima T, Ebihara S.
    • Journal Title

      Nat Genet. 41

      Pages: 688-695

    • Peer Reviewed
  • [Journal Article] Genetic and molecular analysis of wild-derived arrhythmic mice.2009

    • Author(s)
      Watanabe T, Yoshimura T, Ebihara S.
    • Journal Title

      PLoS ONE. 4(1)

      Pages: e4301

    • Peer Reviewed
  • [Journal Article] Melatonin transmits photoperiodic signals through the MT1 melatonin receptor.2009

    • Author(s)
      Yasuo S, Yoshimura T, Ebihara S, Korf HW.
    • Journal Title

      J.Neurosci. 29

      Pages: 2885-2889

    • Peer Reviewed
  • [Journal Article] Reorganization of the suprachiasmatic nucleus coding for day length.2008

    • Author(s)
      Naito E, Watanabe T, Tei H, Yoshimura T, Ebihara S.
    • Journal Title

      J.Biol.Rhythms 23

      Pages: 140-149

    • Peer Reviewed
  • [Journal Article] Thyrotrophin in the pars tuberalis triggers photoperiodic response.2008

    • Author(s)
      Nakao N, Ebihara S, Ueda HR, Yoshimura T.
    • Journal Title

      Nature 452

      Pages: 317-322

    • Peer Reviewed
  • [Journal Article] Involvement of thyrotropin in photoperiodic signal transduction in mice.2008

    • Author(s)
      Ono H, Ebihara S, Korf HW, Yoshimura T.
    • Journal Title

      Proc Natl Acad Sci USA. 105(47)

      Pages: 18238-18242

    • Peer Reviewed
  • [Journal Article] Bimodal clock gene expression in mouse suprachiasmatic nucleus and peripheral tissues under a 7-hour light and 5-hour dark condition.2007

    • Author(s)
      T.Watanabe, T.Yoshimura, S.Ebihara.
    • Journal Title

      J.Biol.Rhythms 22

      Pages: 58-68

    • Peer Reviewed
  • [Journal Article] Hypothalamic expression of thyroid hormone-activating and -inactivating enzyme genes in relation to photorefractoriness in birds and mammals.2007

    • Author(s)
      T.Watanabe, S.Ebihara, T.Yoshimura.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 292

      Pages: R568-R572

    • Peer Reviewed
  • [Journal Article] Differential response of type 2 deiodinase gene expression to photoperiod between photoperiodic Fischer 344 and nonphotoperiodic Wistar rats.2007

    • Author(s)
      S.Yasuo, S.Ebihara, T.Yoshimura.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol. 292(3)

      Pages: R1315-1319

    • Peer Reviewed
  • [Journal Article] Involvement of transforming growth factor α TGF in the photoperiodic regulation of reproduction in birds.2007

    • Author(s)
      T.Takagi, S.Ebihara, T.Yoshimura.
    • Journal Title

      Endocrinology. 148(6)

      Pages: 2788-2792

    • Peer Reviewed
  • [Journal Article] Circadian clock gene regulation of steroidogenic acute regulatory protein gene expression in preovulatory ovarian follicles.2007

    • Author(s)
      N.Nakao, S.Ebihara, T.Yoshimura.
    • Journal Title

      Endocrinology 148

      Pages: 3031-3038

    • Peer Reviewed
  • [Journal Article] Photoperiodic changes in hypothalamic insulin receptor gene expression are regulated by gonadal testosterone.2007

    • Author(s)
      T.Anraku, S.Ebihara, T.Yoshimura.
    • Journal Title

      Brain Res. 1163

      Pages: 86-90

    • Peer Reviewed
  • [Journal Article] Temporal dynamics of type 2 deiodinase expression after melatonin injections in Syrian hamsters.2007

    • Author(s)
      Yasuo S, Yoshimura T, Ebihara S, Korf HW.
    • Journal Title

      Endocrinology 148

      Pages: 4385-4392

    • Peer Reviewed
  • [Journal Article] Long day suppressed expression of type 2 deiodinase gene in the mediobasal hypothalamus of the Saanen goat, a short day breeder : Implication for seasonal window of thyroid hormone action on reproductive neuroendocrine axis.2006

    • Author(s)
      S.Yasuo, S.Ebihara, T.Yoshimura.
    • Journal Title

      Endocrinology 147

      Pages: 432-440

    • Peer Reviewed
  • [Journal Article] Peripheral clock gene expression in CS mice with bimodal locomotor rhythms.2006

    • Author(s)
      T.Watanabe, T.Yoshimura, S.Ebihara.
    • Journal Title

      Neurosci Res. 54

      Pages: 295-301

    • Peer Reviewed
  • [Journal Article] Molecular mechanism of photoperiodic time measurement in the brain of Japanese quail.2006

    • Author(s)
      S.Yasuo, S.Ebihara, T.Yoshimura.
    • Journal Title

      Chronobiology International 23

      Pages: 307-315

    • Peer Reviewed
  • [Journal Article] Possible involvement of organic anion transporting polypeptide 1c1 in the photoperiodic response of gonads in birds.2006

    • Author(s)
      N.Nakao, S.Ebihara, T.Yoshimura.
    • Journal Title

      Endocrinology 147

      Pages: 1067-1073

    • Peer Reviewed
  • [Journal Article] T3 implantation mimics photoperiodically reduced encasement of nerve terminals by glial processes in the median eminence of Japanese quail.2006

    • Author(s)
      T.Yamamura, S.Yasuo, K.Hirunagi, S.Ebihara, T.Yoshimura.
    • Journal Title

      Cell Tissue Res. 324

      Pages: 175-179

    • Peer Reviewed
  • [Journal Article] The reciprocal switching of two thyroid hormone-activating and -inactivating enzyme genes is involved in the photoperiodic gonadal response of Japanese quail.2005

    • Author(s)
      S.Yasuo, S.Ebihara, T.Yoshimura.
    • Journal Title

      Endocrinology 146

      Pages: 2551-2554

    • Peer Reviewed
  • [Journal Article] Estrogen differentially regulates expressions of Per1 and Per2 genes between central and peripheral clocks, and between reproductive and non-reproductive tissues in female rats.2005

    • Author(s)
      T.J.Nakamura, S.Ebihara, K.Shinohara.
    • Journal Title

      J Neurosci Res 82

      Pages: 622-630

    • Peer Reviewed
  • [Presentation] マウスの「行動的絶望」を制御する遺伝子の特定2009

    • Author(s)
      海老原史樹文
    • Organizer
      理研筑波セミナー
    • Year and Date
      2009-05-12
  • [Presentation] "行動的絶望"を司る量的形質遺伝子の特定-リズム異常を示すCSマウスを用いて-、ワークショップ「生物時計研究の展開」2008

    • Author(s)
      海老原史樹文
    • Organizer
      日本遺伝学会第80回大会
    • Year and Date
      20080903-20080905
  • [Presentation] "行動的絶望"を司る遺伝子の特定2008

    • Author(s)
      海老原史樹文
    • Organizer
      川村浩先生アショフ・本間賞受賞記念シンポジウム
    • Place of Presentation
      三菱化学生命科学研究所
    • Year and Date
      2008-04-18
  • [Presentation] MOLECULAR MECHANISMS OF PHOTOPERIODIC TIME MEASUREMENT IN BIRDS2007

    • Author(s)
      Yoshimura T.
    • Organizer
      From Molecular clocks To Human Health Symposium
    • Place of Presentation
      National Wine Centre of Australia
    • Year and Date
      20070707-20070710
  • [Presentation] Reorganization of the suprachiasmatic nucleus by photic and non-photic environments.2007

    • Author(s)
      海老原史樹文
    • Organizer
      2^<nd> Aschoff-Honma Prize Memorial Symposium.
    • Place of Presentation
      Tokyo.
    • Year and Date
      2007-11-06
  • [Presentation] Regional patterns of clock gene expression in the mouse SCN under different environmental conditions2006

    • Author(s)
      海老原史樹文
    • Organizer
      The 22nd International Symposium in Conjunction with Award of the International Prize for Biology "Chronobiology"
    • Place of Presentation
      Tokyo International Forum
    • Year and Date
      20061201-20061202
  • [Presentation]2006

    • Author(s)
      海老原史樹文
    • Organizer
      24th International Ornithological Congress
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      20060813-20060816
  • [Presentation] Identification and characterization of thyroid hormone transporter mediating photoperiodic response in birds2006

    • Author(s)
      Nakao N.
    • Organizer
      10th Meeting of Society for Research on Biological Rhythms
    • Year and Date
      20060521-20060525
  • [Presentation] Molecular understanding of vertebrate photoperiodism.2006

    • Author(s)
      海老原史樹文
    • Organizer
      International Symposium of Chronomedicine and Biological Clocks.
    • Place of Presentation
      Hokkaido University.
    • Year and Date
      2006-07-09
  • [Presentation] Fine tuning of photoperiodic time information in avian brain.2005

    • Author(s)
      S.Yasuo.
    • Organizer
      10^<th> Congress of the European Pineal and Biological Rhythms Society.
    • Place of Presentation
      Frankfurt/Main, Germany
    • Year and Date
      20050901-20050905
  • [Book] 光周性の分子生物学2009

    • Author(s)
      海老原史樹文・井澤毅共編
    • Total Pages
      199
    • Publisher
      シュプリンガー・ジャパン
  • [Book] Melatonin regulation of clock genes in birds. In Functional Avian Endocrinology(A.Dawson & P.J.Sharp eds.)2005

    • Author(s)
      S.Ebihara, S.Yasuo, T.Yoshimura.
    • Total Pages
      215-222
    • Publisher
      Narosa, New Delhi
  • [Remarks] ホームページ

    • URL

      http://www.agr.nagoya-u.ac.jp/~rhythm/

  • [Patent(Industrial Property Rights)] 尾懸垂テスト及び強制水泳テストにおけるマウスの無動化を制御する遺伝子2008

    • Inventor(s)
      海老原史樹文, 冨田滋
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Number
      特許,番号:特許出願2008-104962
    • Filing Date
      2008-04-14

URL: 

Published: 2012-01-26   Modified: 2018-09-26  

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