2008 Fiscal Year Final Research Report
Imaging Study of Dynamic Cellular Signaling
| Project/Area Number |
17109003
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (S)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
IINO Masamitsu The University of Tokyo, 大学院・医学系研究科, 教授 (50133939)
|
|---|
| Project Period (FY) |
2005 – 2008
|
| Keywords | 細胞内情報伝達 / ニューロン・シナプス機能 |
|---|
| Research Abstract |
Ca^<2+> makes bones strong but is also a "switch" for cellular functions. We studied the switching mechanism of Ca^<2+> in the brain and other tissues making use of imaging methods to visualize the switching events. We found new Ca^<2+> switch-dependent mechanisms in the following functions. To keep using neural circuit is required for its maintenance. Glial cells support neuron to extend their processes. Thus, the present study shed new light on the functions of the brain.
|
Research Products
(34 results)
-
[Journal Article] Imaging extrasynaptic glutamate dynamics in the brain2010
Author(s)
Okubo, Y., Sekiya, H., Namiki, S., Sakamoto, H., Iinuma, S., Yamasaki, M., Watanabe, M., Hirose, K., Iino, M.
-
Journal Title
Proc.Natl.Acad.Sci.U.S.A. 107
Pages: 6526-6531
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity2007
Author(s)
Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A, Kondo, H, Kano, M, Watanabe, M, Iino, M., Takeshima, H.
-
Journal Title
EMBO J. 26
Pages: 1924-1933
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Presentation] In vivo imaging of intercellular messengers released from neurons2008
Author(s)
Sekiya, H., Namiki, S., Sakamoto, H., Sho Iinuma, Hirose, K., Iino, M.
Organizer
The 38th Annual Meeting of the Society for Neuroscience
Place of Presentation
Washington Convention Center, Wahsington DC, USA
Year and Date
2008-11-16
-
-
-
[Presentation] Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for cerebellar long-term depression2007
Author(s)
Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, K., Kano, M., Watanabe, M., Iino, M., Takeshima, H.
Organizer
The 37th Annual Meeting of the Society for Neuroscience
Place of Presentation
San Diego Convention Center, San Diego, USA
Year and Date
2007-11-03
-
-
-
-
[Presentation] Visualization of Glutamate Spillover from Synaptic Clefts Using a Novel Fluorescent Glutamate Indicator2006
Author(s)
Okubo, Y., Sekiya, H., Namiki, S., Sakamoto, H., Sho Iinuma, Hirose, K., Iino, M.
Organizer
The 36th Annual Meeting of the Society for Neuroscience
Place of Presentation
Georgia World Congress Center, Atlanta, USA
Year and Date
2006-10-18
-
-
-
[Presentation] Metabotropic glutamate receptor-mediated postsynaptic inositol 1, 4, 5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF2006
Author(s)
Furutani, K., Okubo, Y., Kakizawa, S., Iino, M.
Organizer
5th Forum of European Neuroscience
Place of Presentation
Austria Center Vienna, Vienna, Austria
Year and Date
2006-07-09
-
-
-
-
-
-
-
