2009 Fiscal Year Final Research Report
Systematic study on the mechanism of generation, maintenance and recognition of neuropathic pain, a model of neural plasticity
| Project/Area Number |
17109005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kansai Medical University |
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Principal Investigator |
ITO Seiji Kansai Medical University, 医学部, 教授 (80201325)
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| Co-Investigator(Kenkyū-buntansha) |
ASHITAKA Emiko 関西医科大学, 医学部, 講師 (50291802)
MATSUMURA Shinji 関西医科大学, 医学部, 講師 (70276393)
TSUKADA Hideo 浜松ホトニクス株式会社, 中央研究所, PETセンター長 (10393951)
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| Research Collaborator |
YAO Ikuko 関西医科大学, 医学部, 助教 (60399681)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 慢性疼痛 / 神経可塑性 / 神経再生 / 分子イメージング |
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| Research Abstract |
Neuropathic pain such as postherpetic neuralgia is a clinical problem in Japan of the aged society. Successful pain management is required both for the quality of life of patients suffering from persistent pain and for societal economic costs of pain. Although neuropathic pain has been believed to be intractable due to long-term alterations such as phenotype change and reorganization of neural network in the pain transmission system, the present study demonstrates that chronic pain is generated and maintained by plastic, functional changes such as protein phosphorylation and increase in production/release of biologically active substances caused by continuous inputs from peripheral tissues. We hypothesize that chronic pain is curable and has promoted translational research on objective diagnosis and nerve regeneration for treatment.
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