Study of molecular-genetics, and molecular epidemiology for developing treatment of esophageal cancer

2008 Fiscal Year Final Research Report

• Project/Area Number: 17109013
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Osaka University (2008-2009); Kyushu University (2005-2007)
• Principal Investigator: MORI Masaki Osaka University, 医学系研究科, 教授 (70190999)
• Co-Investigator(Kenkyū-buntansha): TURUMARU Masahiko 順天堂大学, 医学部, 教授 (70155448) ; KATO Hoichi 国立がんセンター, がん対策情報センター, センター長 (60111506) ; FUJITA Hiromasa 久留米大学, 医学部, 教授 (90156878) ; TANAKA Yoichi 埼玉県立がんセンター, 消化器外科, 部長 (10143489) ; TOKUDOME Nobuhiro 名古屋市立大学, 医学部, 教授 (00037441) ; YAMAMOTO Ken 九州大学, 生体防御医学研究所, 准教授 (60274528) ; TANAKA Syoji 鹿児島大学, 大学院・歯学総合研究科, 准教授 (70237577) ; TANAKA Fumiaki 九州大学, 大学病院, 助教 (30332836) ; MIMORI Koshi 九州大学, 生体防御医学研究所, 助教 (50322748)
• Project Period (FY): 2005 – 2008
• Keywords: 食道癌 / 分子遺伝学 / 宿主 / 環境 / 腫瘍

Research Abstract

1)目標を超えて1000例以上の症例、および1000例以上の対照者からの情報を採取した。
2)遺伝子多型解析では、ADH1B,ALDH2遺伝子多型が食道癌発症に関与した。
3)生活習慣では、飲酒、喫煙、運動、大豆製品の摂取などが食道癌発生に関与した。
4)180症例からLMDを行い、食道癌に特異的に高発現する遺伝子324遺伝子)、また低発現している遺伝子群(743遺伝子)を同定した。
5)遺伝子多型と生活習慣をあわせた統合解析、また癌部・非癌部の遺伝子発現の差の網羅的発現解析と生活習慣、遺伝子多型の統合解析を行う。

Research Products

• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells. (2010)
  • Author(s): Miyoshi N, Ishii H, Nagai K, Hoshino H, Mimori K, Tanaka F, Nagano H, Sekimoto M, Doki Y, Mori M.
  • Journal Title: Proc Natl Acad Sci U S A 107(1) Pages: 40-5
  • Peer Reviewed
• [Journal Article] Surgical management for small cell carcinoma of the esophagus. (2010)
  • Author(s): Tanaka T, Matono S, Nagano T, Nishimura K, Murata K, Yamana H, Shirouzu K, Fujita H.
  • Journal Title: Dis Esophagus
  • Peer Reviewed
• [Journal Article] Surgical management for a malignant bowel obstruction with recurrent gastrointestinal carcinoma. (2010)
  • Author(s): Amikura K, Sakamoto H, Yatsuoka T, Kawashima Y, Nishimura Y, Tanaka Y.
  • Journal Title: J Surg Oncol 101(3) Pages: 228-32
  • Peer Reviewed
• [Journal Article] cancer: the esophagus and stomach. (2009)
  • Author(s): Shuto A, Tanaka F, Mimori K, Fujita H, Shirouzu K, Mori M. Upper G.I.
  • Journal Title: II. The current status of comprehensive gene analysis of esophageal cancer] Gan To Kagaku Ryoho 36(9) Pages: 1435-41
  • Peer Reviewed
• [Journal Article] Genetic susceptibility to gastrointestinal cancer: minireview of the genomewide studies. (2009)
  • Author(s): Tokuoka M, Ishii H, Mimori K, Inoue H, Doki Y, Mori M.
  • Journal Title: Ann Surg Oncol 16(7) Pages: 1783-8
  • Peer Reviewed
• [Journal Article] Important matters to identify robust markers for metastasis and recurrence in solid cancer. (2009)
  • Author(s): Mimori K, Iwatsuki M, Yokobori T, Mori M.
  • Journal Title: Ann Surg Oncol 16(4) Pages: 1070-1
  • Peer Reviewed
• [Journal Article] Clinical significance of LAMB3 and COL7A1 mRNA in esophageal squamous cell carcinoma. (2009)
  • Author(s): Kita Y, Mimori K, Tanaka F, Matsumoto T, Haraguchi N, Ishikawa K, Matsuzaki S, Fukuyoshi Y, Inoue H, Natsugoe S, Aikou T, Mori M.
  • Journal Title: Eur J Surg Oncol 35(1) Pages: 52-8
  • Peer Reviewed
• [Journal Article] Salvage esophagectomy after high-dose chemoradiotherapy for esophageal squamous cell carcinoma. (2009)
  • Author(s): Tachimori Y, Kanamori N, Uemura N, Hokamura N, Igaki H, Kato H.
  • Journal Title: J Thorac Cardiovasc Surg 137(1) Pages: 49-54
  • Peer Reviewed
• [Journal Article] Histological diversity in basaloid squamous cell carcinoma of the esophagus. (2009)
  • Author(s): Kobayashi Y, Nakanishi Y, Taniguchi H, Sekine S, Igaki H, Tachimori Y, Kato H, Matsubara H, Okazumi S, Shimoda T.
  • Journal Title: Dis Esophagus 22(3) Pages: 231-8
  • Peer Reviewed
• [Journal Article] Reflux esophagitis and columnar-lined esophagus after cervical esophagogastrostomy (following esophagectomy). (2009)
  • Author(s): Nishimura K, Tanaka T, Tanaka Y, Matono S, Murata K, Shirouzu K, Fujita H.
  • Journal Title: Dis Esophagus
  • Peer Reviewed
• [Journal Article] Yanagawa Esophagectomy for cancer: clinical concerns support centralizing operations within the larger hospitals. (2009)
  • Author(s): Fujita H, Ozawa S, Kuwano H, Ueda Y, Hattori S
  • Journal Title: Dis Esophagus
  • Peer Reviewed
• [Journal Article] Salvage surgery for esophageal cancer (2009)
  • Author(s): Fujita H, Matono S, Tanaka T, Shirouzu K.
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi 106(6) Pages: 779-8
  • Peer Reviewed
• [Journal Article] A history of esophageal surgery in the twentieth century. (2009)
  • Author(s): Kakegawa T, Fujita H.
  • Journal Title: Gen Thorac Cardiovasc Surg 57(2) Pages: 55-63
  • Peer Reviewed
• [Journal Article] Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma. (2009)
  • Author(s): Sasaki K, Natsugoe S, Ishigami S, Matsumoto M, Okumura H, Setoyama T, Uchikado Y, Kita Y, Tamotsu K, Sakamoto A, Owaki T, Aikou T.
  • Journal Title: J Exp Clin Cancer Res 28 Pages: 158
  • Peer Reviewed
• [Journal Article] Expression of CXCL12 and its receptor CXCR4 in esophageal squamous cell carcinoma. (2009)
  • Author(s): Sasaki K, Natsugoe S, Ishigami S, Matsumoto M, Okumura H, Setoyama T, Uchikado Y, Kita Y, Tamotsu K, Hanazono K, Owaki T, Aikou T.
  • Journal Title: Oncol Rep 21(1) Pages: 65-71
  • Peer Reviewed
• [Journal Article] Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad treatment. (2008)
  • Author(s): Mimori K, Ishii H, Inoue H, Barnard GF, Mori M.
  • Journal Title: J Gastroenterol Hepatol 2 Pages: S205-9
  • Peer Reviewed
• [Journal Article] Cancer stem cells and chemoradiation resistance. (2008)
  • Author(s): Ishii H, Iwatsuki M, Ieta K, Ohta D, Haraguchi N, Mimori K, Mori M.
  • Journal Title: Cancer Sci 99(10) Pages: 1871-7
  • Peer Reviewed
• [Journal Article] Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line. (2008)
  • Author(s): Yoshinaga K, Mimori K, Inoue H, Kamohara Y, Yamashita K, Tanaka F, Mori M.
  • Journal Title: Int J Oncol 33(3) Pages: 453-9
  • Peer Reviewed
• [Journal Article] Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes. (2008)
  • Author(s): Ishii H, Mimori K, Ishikawa K, Okumura H, Pichiorri F, Druck T, Inoue H, Vecchione A, Saito T, Mori M, Huebner K.
  • Journal Title: Cancer Res 68(10) Pages: 3662-70
  • Peer Reviewed
• [Journal Article] Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis. (2008)
  • Author(s): Yokoe T, Tanaka F, Mimori K, Inoue H, Ohmachi T, Kusunoki M, Mori M.
  • Journal Title: Cancer Res 68(4) Pages: 1074-82
  • Peer Reviewed
• [Journal Article] Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. (2008)
  • Author(s): Ohta M, Mimori K, Fukuyoshi Y, Kita Y, Motoyama K, Yamashita K, Ishii H, Inoue H, Mori M.
  • Journal Title: Br J Cancer 98(2) Pages: 410-7
  • Peer Reviewed
• [Journal Article] Activin a causes cancer cell aggressiveness in esophageal squamous cell carcinoma cells. (2008)
  • Author(s): Yoshinaga K, Yamashita K, Mimori K, Tanaka F, Inoue H, Mori M.
  • Journal Title: Ann Surg Oncol 15(1) Pages: 96-103
  • Peer Reviewed
• [Journal Article] Two cases of early-stage esophageal malignant melanoma with long-term survival. (2008)
  • Author(s): Suzuki H, Nakanishi Y, Taniguchi H, Shimoda T, Yamaguchi H, Igaki H, Tachimori Y, Kato H.
  • Journal Title: Pathol Int 58(7) Pages: 432-5
  • Peer Reviewed
• [Journal Article] Correlation between loss of Bcl-XL expression and improved prognosis in advanced esophageal cancer treated by preoperative chemoradiotherapy. (2008)
  • Author(s): Okumura M, Kajiyama Y, Takeda K, Okumura K, Tsurumaru M.
  • Journal Title: Eur Surg Res 41(3) Pages: 260-6
  • Peer Reviewed
• [Journal Article] Circulating micrometastases of esophageal cancer detected by carcinoembryonic antigen mRNA reverse transcriptase-polymerase chain reaction: clinical implications. (2008)
  • Author(s): Hashimoto T, Kajiyama Y, Tsutsumi-Ishii Y, Nagaoka I, Tsurumaru M.
  • Journal Title: Dis Esophagus 21(8) Pages: 690-6
  • Peer Reviewed
• [Journal Article] Lymphatic invasion according to D2-40 immunostaining is a strong predictor of nodal metastasis in superficial squamous cell carcinoma of the esophagus: algorithm for risk of nodal metastasis based on lymphatic invasion. (2008)
  • Author(s): Tomita N, Matsumoto T, Hayashi T, Arakawa A, Sonoue H, Kajiyama Y, Tsurumaru M.
  • Journal Title: Pathol Int 58(5) Pages: 282-7
  • Peer Reviewed
• [Journal Article] Expression of CXCL12 and its receptor CXCR4 correlates with lymph node metastasis in submucosal esophageal cancer. (2008)
  • Author(s): Sasaki K, Natsugoe S, Ishigami S, Matsumoto M, Okumura H, Setoyama T, Uchikado Y, Kita Y, Tamotsu K, Sakurai T, Owaki T, Aikou T.
  • Journal Title: J Surg Oncol 97(5) Pages: 433-8
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma. (2008)
  • Author(s): Takatori H, Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Setoyama T, Sasaki K, Tamotsu K, Owaki T, Ishigami S, Aikou T.
  • Journal Title: Eur J Surg Oncol 34(4) Pages: 397-402
  • Peer Reviewed
• [Journal Article] Rad9 modulates the P21WAF1 pathway by direct association with p53. (2007)
  • Author(s): Ishikawa K, Ishii H, Murakumo Y, Mimori K, Kobayashi M, Yamamoto K, Mori M, Nishino H, Furukawa Y, Ichimura K.
  • Journal Title: BMC Mol Biol 8 Pages: 37
  • Peer Reviewed
• [Journal Article] BAC clones related to prognosis in patients with esophageal squamous carcinoma: an array comparative genomic hybridization study. (2007)
  • Author(s): Hirasaki S, Noguchi T, Mimori K, Onuki J, Morita K, Inoue H, Sugihara K, Mori M, Hirano T.
  • Journal Title: Oncologist 12(4) Pages: 406-17
  • Peer Reviewed
• [Journal Article] Identification of EGFR mutations in esophageal cancer. (2007)
  • Author(s): Sudo T, Mimori K, Nagahara H, Utsunomiya T, Fujita H, Tanaka Y, Shirouzu K, Inoue H, Mori M.
  • Journal Title: Eur J Surg Oncol 33(1) Pages: 44-8
  • Peer Reviewed
• [Journal Article] Subepithelial extension of squamous cell carcinoma in the esophagus: histopathological study using D2-40 immunostaining for 108 superficial carcinomas. (2007)
  • Author(s): Amano T, Matsumoto T, Hayashi T, Arakawa A, Sonoue H, Kajiyama Y, Tsurumaru M.
  • Journal Title: Pathol Int 57(12) Pages: 759-64
  • Peer Reviewed
• [Journal Article] Second-line combination chemotherapy with docetaxel for cisplatin-pretreated refractory metastatic esophageal cancer: a preliminary report of initial experience. (2007)
  • Author(s): Tanaka T, Fujita H, Sueyoshi S, Tanaka Y, Sasahara H, Mori N, Nagano T, Yamana H, Shirouzu K.
  • Journal Title: Chemotherapy 53(6) Pages: 449-53
  • Peer Reviewed
• [Journal Article] Guidelines for the Diagnosis and Treatment of Esophageal Cancer: clinical efficacy and impact (2007)
  • Author(s): Fujita H, Tsubuku T, Tanaka T, Tanaka Y, Matono S, Shirouzu K.
  • Journal Title: Nippon Geka Gakkai Zasshi 108(5) Pages: 246-52
  • Peer Reviewed
• [Journal Article] Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma. (2007)
  • Author(s): Yokomakura N, Natsugoe S, Okumura H, Ikeda R, Uchikado Y, Mataki Y, Takatori H, Matsumoto M, Owaki T, Ishigami S, Aikou T.
  • Journal Title: Oncol Rep 18(3) Pages: 561-7
  • Peer Reviewed
• [Journal Article] Isolated tumour cells in blood and E-cadherin expression in oesophageal squamous cell cancer. (2007)
  • Author(s): Setoyama T, Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Aikou T.
  • Journal Title: Br J Surg 94(8) Pages: 984-91
  • Peer Reviewed
• [Journal Article] Snail plays a key role in E-cadherin-preserved esophageal squamous cell carcinoma. (2007)
  • Author(s): Natsugoe S, Uchikado Y, Okumura H, Matsumoto M, Setoyama T, Tamotsu K, Kita Y, Sakamoto A, Owaki T, Ishigami S, Aikou T.
  • Journal Title: Oncol Rep 17(3) Pages: 517-23
  • Peer Reviewed
• [Journal Article] alpha-catenin is a significant prognostic factor than E-cadherin in esophageal squamous cell carcinoma. (2007)
  • Author(s): Setoyama T, Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Yokomakura N, Ishigami S, Aikou T.
  • Journal Title: J Surg Oncol 95(2) Pages: 148-55
  • Peer Reviewed
• [Journal Article] Fhit modulates the DNA damage checkpoint response. (2006)
  • Author(s): Ishii H, Mimori K, Inoue H, Inageta T, Ishikawa K, Semba S, Druck T, Trapasso F, Tani K, Vecchione A, Croce CM, Mori M, Huebner K.
  • Journal Title: Cancer Res 66(23 Pages: 11287-92
  • Peer Reviewed
• [Journal Article] Gene expression profiling of lymph node metastasis by oligomicroarray analysis using laser microdissection in esophageal squamous cell carcinoma. (2006)
  • Author(s): Uchikado Y, Inoue H, Haraguchi N, Mimori K, Natsugoe S, Okumura H, Aikou T, Mori M.
  • Journal Title: Int J Oncol 29(6) Pages: 1337-47
  • Peer Reviewed
• [Journal Article] Cancer stem cells in human gastrointestinal cancers. (2006)
  • Author(s): Haraguchi N, Inoue H, Tanaka F, Mimori K, Utsunomiya T, Sasaki A, Mori M.
  • Journal Title: Hum Cell (1) Pages: 24-9
  • Peer Reviewed
• [Journal Article] FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression. (2006)
  • Author(s): Mimori K, Ishii H, Nagahara H, Sudo T, Yamashita K, Inoue H, Barnard GF, Mori M.
  • Journal Title: Cancer Res 66(5) Pages: 2683-90
  • Peer Reviewed
• [Journal Article] Characterization of a side population of cancer cells from human gastrointestinal system. (2006)
  • Author(s): Haraguchi N, Utsunomiya T, Inoue H, Tanaka F, Mimori K, Barnard GF, Mori M.
  • Journal Title: Stem Cells (3) Pages: 506-13
• [Journal Article] Histopathological criteria for additional treatment after endoscopic mucosal resection for esophageal cancer: analysis of 464 surgically resected cases. (2006)
  • Author(s): Eguchi T, Nakanishi Y, Shimoda T, Iwasaki M, Igaki H, Tachimori Y, Kato H, Yamaguchi H, Saito D, Umemura S.
  • Journal Title: Mod Pathol 19(3) Pages: 475-80
  • Peer Reviewed
• [Journal Article] Alvocidib (Flavopiridol) suppresses tumor growth in SCID mice with human esophageal cancer xenografts without inducing apoptosis. (2006)
  • Author(s): Sato S, Kajiyama Y, Sugano M, Iwanuma Y, Sonoue H, Matsumoto T, Tsurumaru M.
  • Journal Title: Surg Oncol 15(2) Pages: 107-13
  • Peer Reviewed
• [Journal Article] Clinical pathways in the treatment of cancers (2006)
  • Author(s): Tanaka T, Tousaka T, Fujita H.
  • Journal Title: Gan To Kagaku Ryoho 33(11) Pages: 1568-70
  • Peer Reviewed
• [Journal Article] Long-term survival after three-field lymph-adenectomy for an adenocarcinoma in Barrett's esophagus with metastasis to Virchow's node. (2006)
  • Author(s): Matono S, Fujita H, Sueyoshi S, Tanaka T, Yamana H, Shirouzu K.
  • Journal Title: Jpn J Thorac Cardiovasc Surg 54(1) Pages: 11-5
  • Peer Reviewed
• [Journal Article] Randomized controlled study on preoperative chemoradiotherapy followed by surgery versus surgery alone for esophageal squamous cell cancer in a single institution. (2006)
  • Author(s): Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Setoyama T, Yokomakura N, Ishigami S, Owaki T, Aikou T.
  • Journal Title: Dis Esophagus 19(6) Pages: 468-72
  • Peer Reviewed
• [Journal Article] Carcinoembryonic antigen messenger RNA expression in blood predicts recurrence in esophageal cancer. (2006)
  • Author(s): Setoyama T, Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Ishigami S, Owaki T, Takao S, Aikou T.
  • Journal Title: Clin Cancer Res 12(201) Pages: 5972-7
  • Peer Reviewed
• [Journal Article] Expression of osteopontin in oesophageal squamous cell carcinoma. (2006)
  • Author(s): Kita Y, Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Setoyama T, Owaki T, Ishigami S, Aikou T.
  • Journal Title: Br J Cancer 95(5) Pages: 634-8
  • Peer Reviewed
• [Journal Article] Overexpression of vascular endothelial growth factor-C correlates with lymph node micrometastasis in submucosal esophageal cancer. (2006)
  • Author(s): Matsumoto M, Natsugoe S, Okumura H, Arima H, Yanagita S, Uchikado Y, Yokomakura N, Setoyama T, Ishigami S, Takao S, Aikou T.
  • Journal Title: J Gastrointest Surg 10(7) Pages: 1016-22
  • Peer Reviewed
• [Journal Article] Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinoma. (2006)
  • Author(s): Okumura H, Natsugoe S, Yokomakura N, Kita Y, Matsumoto M, Uchikado Y, Setoyama T, Owaki T, Ishigami S, Aikou T
  • Journal Title: Clin Cancer Res 12(12) Pages: 3740-5
  • Peer Reviewed
• [Journal Article] Distribution of p53 mutations in esophageal and gastric carcinomas and the relationship with p53 expression. (2006)
  • Author(s): Hanazono K, Natsugoe S, Stein HJ, Aikou T, Hoefler H, Siewert JR.
  • Journal Title: Oncol Rep 15(4) Pages: 821-4
  • Peer Reviewed
• [Journal Article] Differentially expressed genes in endothelial differentiation. (2005)
  • Author(s): Ishii H, Mimori K, Mori M, Vecchione A.
  • Journal Title: DNA Cell Biol 24(7) Pages: 432-7
  • Peer Reviewed
• [Journal Article] Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. (2005)
  • Author(s): Ishii H, Inageta T, Mimori K, Saito T, Sasaki H, Isobe M, Mori M, Croce CM, Huebner K, Ozawa K, Furukawa Y.
  • Journal Title: Proc Natl Acad Sci U S A 102(27) Pages: 9655-60
  • Peer Reviewed
• [Journal Article] PGP9. 5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma. (2005)
  • Author(s): Mandelker DL, Yamashita K, Tokumaru Y, Mimori K, Howard DL, Tanaka Y, Carvalho AL, Jiang WW, Park HL, Kim MS, Osada M, Mori M, Sidransky D.
  • Journal Title: Cancer Res 65(11) Pages: 4963-8
  • Peer Reviewed
• [Journal Article] Components of DNA damage checkpoint pathway regulate UV exposure-dependent alterations of gene expression of FHIT and WWOX at chromosome fragile sites. (2005)
  • Author(s): Ishii H, Mimori K, Inageta T, Murakumo Y, Vecchione A, Mori M, Furukawa Y.
  • Journal Title: Mol Cancer Res 3(3) Pages: 130-8
  • Peer Reviewed
• [Journal Article] Surgery for clinical T3 carcinomas of the upper thoracic oesophagus and the need for new strategies. (2005)
  • Author(s): Igaki H, Kato H, Tachimori Y, Nakanishi Y, Shimoda T.
  • Journal Title: Br J Surg 92(10) Pages: 1235-40
  • Peer Reviewed
• [Journal Article] Surgery for cancer of the esophagus in elderly patients, Sealing the (2005)
  • Author(s): Kajiyama Y, Tsurumaru M. Kajiyama Y, Iwanuma Y, Tomita N, Amano T
  • Journal Title: Kyobu Geka, Hepatogastroenterology 58(8),52(64) Pages: 756-61, 1053-6
  • Peer Reviewed
• [Journal Article] Sealing the thoracic duct with ultrasonic coagulating shears. (2005)
  • Author(s): Nishimura K, Fujita H, Tanaka T, Matono S, Nagano T, Murata K, Umeno H, Yanagawa T, Shirouzu K.
  • Journal Title: Hepatogastroenterology 52(64) Pages: 1053-6
  • Peer Reviewed
• [Journal Article] Prospective non-randomized trial comparing esophagectomy-followed-by-chemoradiother apy versus chemoradiotherapy-followed-by-esophagect omy for T4 esophageal cancers. (2005)
  • Author(s): Fujita H, Sueyoshi S, Tanaka T, Tanaka Y, Sasahara H, Shirouzu K, Suzuki G, Hayabuchi N, Inutsuka H.
  • Journal Title: J Surg Oncol 90(4) Pages: 209-19
  • Peer Reviewed
• [Journal Article] A novel Myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma. (2005)
  • Author(s): Tsuneoka M, Teye K, Arima N, Soejima M, Otera H, Ohashi K, Koga Y, Fujita H, Shirouzu K, Kimura H, Koda Y.
  • Journal Title: J Biol Chem 280(20) Pages: 19977-85
  • Peer Reviewed
• [Journal Article] Predictive value of p53 and 14-3-3sigma for the effect of chemoradiation therapy on esophageal squamous cell carcinoma. (2005)
  • Author(s): Okumura H, Natsugoe S, Matsumoto M, Yokomakura N, Uchikado Y, Takatori H, Ishigami S, Takao S, Aikou T.
  • Journal Title: J Surg Oncol 91(1) Pages: 84-9
  • Peer Reviewed
• [Journal Article] Reconstruction of recurrent laryngeal nerve with involvement by metastatic node in esophageal cancer. (2005)
  • Author(s): Natsugoe S, Okumura H, Matsumoto M, Ishigami S, Owaki T, Nakano S, Aikou T.
  • Journal Title: Ann Thorac Surg 79(6) Pages: 1886-9
  • Peer Reviewed
• [Presentation] 炎症性発癌刺激による食道発癌・進展に対するFHITを介した抑制機構の解明 (2009)
  • Author(s): 真船健一, 久保田啓介, 黒田純子, 三森功士, 石井秀始, 北島政樹, 森正樹
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡サージカルフォーラム
  • Year and Date: 2009-04-02
• [Presentation] 難治性食道癌における放射線科学療法抵抗性とFHIT消失との関係について (2008)
  • Author(s): 三森功士, 石井秀始, 主藤朝也, 永原央, 井上裕, 森正樹
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋ワークショップ
  • Year and Date: 2008-10-29
• [Presentation] 食道癌転移・浸潤におけるアクチビンAの分子機序 (2008)
  • Author(s): 吉永敬士, 三森功士, 山下継史, 田中文明, 掛地吉弘, 井上裕, 森正樹
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋一般ポスター
  • Year and Date: 2008-10-28
• [Presentation] 食道発癌機構における癌抑制遺伝子FHITの役割の解明 (2008)
  • Author(s): 三森功士, 井上裕, 森正樹
  • Organizer: 第63回日本消化器外科学会定期学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-16
• [Presentation] 食道癌の発生・進展に関わる因子の解析 (2007)
  • Author(s): 田中文明, 三森功士, 蒲原行雄, 鶴丸昌彦, 加藤抱一, 藤田博正, 田中洋一, 愛甲孝, 徳留信寛, 山本健, 井上裕, 森正樹
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜(シンポジウム)
  • Year and Date: 2007-10-05
• [Presentation] 食道癌におけるSTC2の高発現とその意義 (2007)
  • Author(s): 喜多芳昭, 三森功士, 田中文明, 蒲原行雄, 井上裕, 夏越祥次, 森正樹
  • Organizer: 第40回日本胸部外科学会九州地方会総会
  • Place of Presentation: 久留米シンポジウム
  • Year and Date: 2007-07-26
• [Presentation] 食道扁平上皮癌におけるリンパ節転移関連遺伝子の同定 (2007)
  • Author(s): 喜多芳昭, 三森功士, 田中文明, 原口直紹, 石川健二, 松本敏文, 井上裕, 夏越祥次, 愛甲孝, 森正樹
  • Organizer: 第62回日本消化器外科学会定期学術総会
  • Place of Presentation: 東京都
  • Year and Date: 2007-07-20
• [Presentation] 消化器癌への樹状細胞と癌抗原を用いた癌ワクチン治療;これまでとこれから (2007)
  • Author(s): 田中文明, 原口直紹, 横江毅, 石川健二, 三森功士, 蒲原行雄, 井上裕, 森正樹
  • Organizer: 第63回日本消化器外科学会定期学術集会
  • Place of Presentation: 札幌パネルディスカッション
  • Year and Date: 2007-07-17
• [Presentation] 癌幹細胞を標的とした新規癌免疫治療の意義 (2007)
  • Author(s): 田中文明, 川本恵, 原口直紹, 石川健二, 三森功士, 松本敏文, 井上裕, 森正樹
  • Organizer: 第28回癌免疫外科研究会
  • Place of Presentation: 東京都
  • Year and Date: 2007-05-25
• [Presentation] 消化器癌に対する樹状細胞を用いた癌特異的免疫治療:これまでの成果と今後の工夫 (2007)
  • Author(s): 田中文明, 原口直紹, 石川健二, 小坂愉賢, 張翔, 松本敏文, 井上裕, 森正樹
  • Organizer: 第107回日本外科学会定期学術集会
  • Place of Presentation: 大阪(ワークショップ)
  • Year and Date: 2007-04-13
• [Presentation] 食道扁平上皮癌におけるLAMB3とCOL7A1の発現意義 (2007)
  • Author(s): 喜多芳昭, 三森功士, 中村能人, 坂下克也, 井上裕, 夏越祥次, 愛甲孝, 森正樹
  • Organizer: 第107回日本外科学会定期学術集会
  • Place of Presentation: 大阪ポスター
  • Year and Date: 2007-04-11
• [Presentation] Inoue H Cancer stem cell research in solid cancer International (2007)
  • Author(s): Mori M, Haraguchi N, Tanaka F, Mimori K, Matsumoto T
  • Organizer: Symposium on Tumor Biology in Kanazawa
  • Place of Presentation: Kanazawa (invited lecture)
  • Year and Date: 2007-01-25
• [Presentation] 食道扁平上皮癌におけるLAMB3とCOL7A1の発現 (2006)
  • Author(s): 喜多芳昭, 田中文明, 三森功士, 原口直紹, 松本敏文, 井上裕, 夏越祥次, 愛甲孝, 森正樹
  • Organizer: 第19回日本バイオセラピイ学会学術集会総会
  • Place of Presentation: 福岡(ワークショップ)
  • Year and Date: 2006-12-01
• [Presentation] Mori M Cancer-death related genomic aberration of esophageal squamous cell carcinoma revealed by array-based comparative genomic hybridization. (2006)
  • Author(s): Hirasaki S, Inoue H, Noguchi T, Hirano T, Sugihara K
  • Organizer: The 11th International Congress of Metastasis Research Society
  • Place of Presentation: 徳島ポスター
  • Year and Date: 2006-09-05
• [Presentation] 食道扁平上皮癌におけるOsteopontin発現の意義第山下継史、森正樹、渡邉昌彦食道癌の腫瘍造性を抑制する重要遺伝子HOPの同定とその臨床的応用 (2006)
  • Author(s): 喜多芳昭, 夏越祥次, 奥村浩, 内門泰斗, 松本正隆, 井上裕, 原口直紹, 三森功士, 森正樹, 愛甲孝
  • Organizer: 第61回日本消化器外科学会定期学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2006-07-14
• [Presentation] 今後の癌特異的免疫療法の工夫 (2006)
  • Author(s): 田中文明, 原口直紹, 石川健二, 佐々木淳, 井上裕, 森正樹
  • Organizer: 第61回日本消化器外科学会定期学術総会
  • Place of Presentation: 横浜(シンポジウム)
  • Year and Date: 2006-07-13
• [Presentation] 消化器癌に対する分子生物学の貢献 (2006)
  • Author(s): 森正樹
  • Organizer: 第61回日本消化器外科学会定期学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2006-07-13
• [Presentation] 高度先進医療としての樹状細胞療法 (2006)
  • Author(s): 田中文明, 原口直紹, 小坂愉賢, 三森功士, 松本敏文, 井上裕, 森正樹
  • Organizer: 日本リンパ網内系学会
  • Place of Presentation: 名古屋(シンポジウム)
  • Year and Date: 2006-06-30
• [Presentation] 今後の癌ワクチン治療の工夫 (2006)
  • Author(s): 田中文明, 原口直紹, 石川健二, 三森功士, 佐々木淳, 井上裕, 森正樹
  • Organizer: 第27回癌免疫外科研究会
  • Place of Presentation: 北九州(シンポジウム)
  • Year and Date: 2006-06-01
• [Presentation] 消化器癌におけるEGFR突然変異の検索とgefitinibの適応拡大 (2006)
  • Author(s): 田中洋一, 三森功士, 永原央, 主藤朝也, 原口直紹, 石川健二, 川島吉之, 西村洋治, 森正樹
  • Organizer: 第106回日本外科学会定期学術集会
  • Place of Presentation: 東京都ポスター
  • Year and Date: 2006-03-31
• [Presentation] 消化器癌におけるKIF14発現の検討 (2006)
  • Author(s): 真船健一, 中村能人, 三森功士, 田中文明, 佐々木淳, 久保田啓介, 井上裕, 森正樹
  • Organizer: 第106回日本外科学会定期学術集会
  • Place of Presentation: 東京都(サージカルフォーラム)
  • Year and Date: 2006-03-30
• [Presentation] Adenovirus-FHIT遺伝子治療の分子機序と抗腫瘍効果が期待される食道癌の特徴 (2006)
  • Author(s): 松山歩, 三森功士, 田中文明, 佐々木淳, 井上裕, 田中洋一, 真船健一, 森正樹
  • Organizer: 第106回日本外科学会定期学術集会
  • Place of Presentation: 東京都(サージカルフォーラム)
  • Year and Date: 2006-03-30
• [Presentation] 癌における微少転移検出法の実際と臨床応用 (2006)
  • Author(s): 山下継史, 桜本信一, 菊池史郎, 片田夏也, 二渡信江, 森正樹, 渡邉昌彦
  • Organizer: 第106回日本外科学会定期学術集会
  • Place of Presentation: 東京都ワークショップ
  • Year and Date: 2006-03-30
• [Presentation] 食道癌における放射線化学療法耐性関連遺伝子の同定 (2006)
  • Author(s): 主籐朝也, 三森功士, 田中文明, 家田敬輔, 井上裕, 藤田博正, 白水和雄, 森正樹
  • Organizer: 第106回日本外科学会定期学術集会
  • Place of Presentation: 東京都(ワークショップ)
  • Year and Date: 2006-03-29
• [Presentation] 消化器癌の発生と進展 (2005)
  • Author(s): 森正樹
  • Organizer: 日本消化器癌発生学会
  • Place of Presentation: 鹿児島ランチョンセミナー
  • Year and Date: 2005-10-14
• [Presentation] 消化器癌化学療法の最適化をめぐってがん幹細胞の概念に基づく消化器癌化学療法の最適化 (2005)
  • Author(s): 宇都宮徹, 原口直紹, 家田敬輔, 田中文明, 三森功士, 井上裕, 森正樹
  • Organizer: 第60回日本消化器外科学会定期学術総会
  • Place of Presentation: 東京都(ワークショップ)
  • Year and Date: 2005-07-21
• [Presentation] 食道癌におけるマイクロアレイを用いた放射線化学療法耐性関連遺伝子の解析 (2005)
  • Author(s): 主藤朝也, 三森功士, 田中文明, 岡本正博, 松山歩, 宇都宮徹, 井上裕, 藤田博正, 白水和雄, 森正樹
  • Organizer: 第60回日本消化器外科学会定期学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2005-07-21
• [Presentation] 消化器癌における分子標的薬の導入に関する研究(EGFR阻害剤の適応拡大と合併症の予防) (2005)
  • Author(s): 三森功士, 永原央, 山下継史, 主藤朝也, 吉永敬士, 井上裕, 森正樹
  • Organizer: 第60回日本消化器癌外科学会定期学術総会
  • Place of Presentation: 東京都
  • Year and Date: 2005-07-20
• [Presentation] 食道扁平上皮癌におけるリンパ節転移に関する遺伝子発現解析 (2005)
  • Author(s): 内門泰斗, 井上裕, 原口直紹, 三森功士, 夏越祥次, 奥村浩, 愛甲孝, 森正樹
  • Organizer: 第60回日本消化器外科学会定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2005-07-20
• [Presentation] 樹状細胞と癌抗原ペプチドを用いた進行消化器癌患者に対する癌ワクチン療法:有効な症例とは (2005)
  • Author(s): 田中文明, 森正樹
  • Organizer: 第26回癌免疫外科研究会
  • Place of Presentation: 東京都(シンポジウム)
  • Year and Date: 2005-05-20
• [Presentation] 食道癌におけるメチル化された癌抑制遺伝子群の同定と臨床病理学的意義 (2005)
  • Author(s): 家田敬輔, 主藤朝也, 太田光彦, 大町貴弘, 松山歩, 岡本正博, 三森功士, 桑野博行, 森正樹
  • Organizer: 第105回日本外科学会定期学術集会
  • Place of Presentation: 名古屋ポスター
  • Year and Date: 2005-05-13
• [Presentation] LMD, Microarrayを用いた胃癌における癌特異的遺伝子の検索 (2005)
  • Author(s): 中村能人, 永原央, 太田光彦, 大町貴弘, 田中正博, 宇都宮徹, 井上裕, 矢永勝彦, 森正樹
  • Organizer: 第105回日本外科学会定期学術集会
  • Place of Presentation: 名古屋(サージカルフォーラム)
  • Year and Date: 2005-05-12
• [Presentation] 「外科侵襲に対する生体反応:最新の知見」腹腔鏡手術における生体侵襲からみた利点;包括的遺伝子発現解析を用いた研究 (2005)
  • Author(s): 田中文明, 園田英人, 岡本正博, 松山歩, 三森功士, 宇都宮徹, 井上裕, 森正樹
  • Organizer: 第105回日本外科学会定期学術集会
  • Place of Presentation: 名古屋(シンポジウム)
  • Year and Date: 2005-05-12
• [Presentation] 食道発癌課程におけるMAL遺伝子発現消失の機序とその意義 (2005)
  • Author(s): 西田康二郎, 三森功士, 宇都宮徹, 岡本正博, 松山歩, 田中文明, 井上裕, 森正樹
  • Organizer: 第105回日本外科学会定期学術集会
  • Place of Presentation: 名古屋(サージカルフォーラム)
  • Year and Date: 2005-05-12
• [Presentation] 食道癌のDNAメチル化研究は癌診療に寄与するか (2005)
  • Author(s): 山下継史, 三森功士, 田中文明, 宇都宮徹, 井上裕, 森正樹
  • Organizer: 第105回日本外科学会定期学術集会
  • Place of Presentation: 名古屋(サージカルフォーラム)
  • Year and Date: 2005-05-12