2009 Fiscal Year Final Research Report
Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination
| Project/Area Number |
17109015
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
UEDA Hiroshi Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (00145674)
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| Co-Investigator(Kenkyū-buntansha) |
SUMIKAWA Koji 長崎大学, 大学院・医歯薬学総合研究科, 教授 (60028660)
INOUE Makoto 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (60380987)
FUJITA Ryousuke 長崎大学, 大学院・医歯薬学総合研究科, 助教 (70380855)
UCHIDA Hitoshi 長崎大学, 大学院・医歯薬学総合研究科, 技術補佐員 (30549621)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 脳・神経 / 脂質 / 神経因性疼痛 / 脱髄 / 神経回路 |
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| Research Abstract |
We successfully identified various molecular targets for medicines to cure neuropathic pain. They are related to the lysophospahtidic acid (LPA)-mediated mechanisms underlying injury-induced demyelination, gene regulation, microglia activation and supra-spinal pain. Feed-forward amplification of these mechanisms and epigenetic gene regulation of key pain-related molecules were suggested to underlie the chronic status of neuropathic pain.
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