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2007 Fiscal Year Final Research Report Summary

Molecular and cell biological studies on the production, aggregation and clearance of Alzheimer amyloid β peptides.

Research Project

Project/Area Number 17200025
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe University of Tokyo

Principal Investigator

IWATSYBO Takeshi  The University of Tokyo, Graduate School of Pharmaceutical Sciences, Professor (50223409)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Tadafumi  The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor (30334337)
Project Period (FY) 2005 – 2007
KeywordsAlzheimer's disease / γ-Secretase / Amyloid / amyloid binding protein / Aβ
Research Abstract

The aim of this research project is to elucidate the process of production, accumulation and clearance of amyloid β peptides, that are regarded as pathogenic proteins in Alzheimer's disease (AD), thereby creating a novel concept for the disease-modifying therapy for AD. Through the studies of γ-secretase, a membrane protease that produces Aβ peptide, we tried to clarify the mechanism of Aβ production and to block the most upstream cause of AD. Specifically we developed novel γ-secretase inhibitors harboring an enone-moiety and analyzed the mechanism of action of these compounds. Using Cys scan approach, we showed that the 6/7 transmembrane domains of presenilin 1, the latter being the catalytic subunit of γ-secretase, form a hydrophilic catalytic pore structure, We further analyzed the structure of γ-secretase and a related protease, SPP, using single particle analysis. We showed that CLAC, a novel amyloid plaque component protein, inhibits Aβ fibril formation in vitro, and is involved in the compaction of amyloid plaques in the brains of transgenic mice. We also showed that LRP1 is involved in the clearance of All peptides across the blood brain barrier, using an immortalized cell line of brain endothelial cells. We thus elucidated the key steps of Aβ deposition, i.e., γ-secretase, amyloid binding protein and Aβ clearance, using cutting edge technologies including proteomic analysis, RNAi and small molecule screen, providing clues to the development of novel therapeutic strategies for AD.

  • Research Products

    (63 results)

All 2008 2007 2006 2005 Other

All Journal Article (38 results) (of which Peer Reviewed: 19 results) Presentation (24 results) Remarks (1 results)

  • [Journal Article] Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase: common effects of Pen-2 amino-terminal elongation and fenofibrate.2007

    • Author(s)
      Isoo N
    • Journal Title

      J Biol Chem 282

      Pages: 12388-12396

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic γ-secretase inhibitors.2007

    • Author(s)
      Fuwa H
    • Journal Title

      ACS Chem Biol 2

      Pages: 408-418

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The Tottori (D7N) and English (H6R) familial Alzheimer's disease mutations accelerate A β fibril formation without increasing protofibril formation.2007

    • Author(s)
      Hori Y
    • Journal Title

      J Biol Chem 282

      Pages: 4916-4923

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Convenient synthesis of photoaffinity probes and evaluation of their cross-linking abilities2007

    • Author(s)
      Kan T^*, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T
    • Journal Title

      Org lett 9

      Pages: 2055-2058

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase : common effects of Pen-2 amino-terminal elongation and fenofibrate2007

    • Author(s)
      Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T^*, Iwatsubo T^*
    • Journal Title

      J Biol Chem 282

      Pages: 12388-12396

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic γ-secretase inhibitors2007

    • Author(s)
      Fuwa H^*, Konno Y, Takahashi Y, Sasaki M, Yokoshima S, Kan T, Fukuyama T, Natsugari H, Tomita T^*, Iwatsubo T
    • Journal Title

      ACS Chem Biol 2

      Pages: 408-418

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The Tottori (D7N) and English (H6R) familial Alzheimer's disease mutations accelerate All fibril formation without increasing protofibril formation2007

    • Author(s)
      Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T
    • Journal Title

      J Biol Chem 282

      Pages: 4916-4923

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Three-dimensional structure of the γ-secretase complex.2006

    • Author(s)
      Ogura T
    • Journal Title

      Biochem Biophys Res Comm 343

      Pages: 325-343

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Carboxyl-terminal fragment of presenilin is the molecular target of a dipeptidic γ-secretase-specific inhibitor DAPT.2006

    • Author(s)
      Morohashi Y
    • Journal Title

      J Biol Chem 281

      Pages: 14670-14676

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Presenilin-dependent intramembrane cleavage of ephrin-B12006

    • Author(s)
      Tomita T
    • Journal Title

      Mol Neurodegener 1

      Pages: 2

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.2006

    • Author(s)
      Takahashi Y
    • Journal Title

      Bioorg Med Chem Lett 16

      Pages: 3813-3816

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. Design, synthesis, enzymatic BACE-1 and cell assays.2006

    • Author(s)
      Garino C
    • Journal Title

      J Med Chem 49

      Pages: 4725-4285

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors.2006

    • Author(s)
      Fuwa H
    • Journal Title

      Bioorg Med Chem Lett 16

      Pages: 4184-4189

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis.2006

    • Author(s)
      Ozaki T
    • Journal Title

      Biochem Biophys Res Comm 351

      Pages: 57-63

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Structure of the catalytic pore of γ-secretase probed by the accessibility of substituted cysteines.2006

    • Author(s)
      Sato C
    • Journal Title

      J Neurosci 26

      Pages: 12081-12088

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Concise and short synthesis of functionalized 5,6-Dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates.2006

    • Author(s)
      Fuwa H
    • Journal Title

      Heterocycles 70

      Pages: 101-106

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver.2006

    • Author(s)
      Tamaki C
    • Journal Title

      Pharmaceut Res 23

      Pages: 1407-1416

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Convenient synthesis of photoaffinity probes and evaluation of their cross-linking abilities.2006

    • Author(s)
      Kan T
    • Journal Title

      Org lett 9

      Pages: 2055-2058

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Three-dimensional structure of the γ-secretase complex2006

    • Author(s)
      Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T^*, Sato C^*
    • Journal Title

      Biochem Biophys Res Comm 343

      Pages: 525-534

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] C-terminal fragment of Presenilin is the molecular target of a dipeptidic γ-secretase-specific Inhibitor DAPT2006

    • Author(s)
      Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T^*, Tomita T^*
    • Journal Title

      J Biol Chem 281

      Pages: 14670-14676

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Presenilin-dependent intramembrane cleavage of ephrin-B12006

    • Author(s)
      Tomita T^*, Tanaka S, Morohashi Y, Iwatsubo T^*
    • Journal Title

      Molecular Neurodegeneration 1

      Pages: 2

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates2006

    • Author(s)
      Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T^*, Tomita T, Natsugari H^*, Fukuyama T
    • Journal Title

      Bioorg Med Chem Lett 16

      Pages: 3813-3816

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. Design, synthesis, enzymatic BACE-1 and cell assays2006

    • Author(s)
      Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quelever G, Iwatsubo T, Kraus J. -L^*
    • Journal Title

      J Med Chem 49

      Pages: 4275-4285

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors2006

    • Author(s)
      Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H^*
    • Journal Title

      Bioorg Med Chem Lett 16

      Pages: 4184-4189

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis2006

    • Author(s)
      Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A^*
    • Journal Title

      Biochem Biophys Res Comm 351

      Pages: 57-63

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Structure of the catalytic pore of γ-secretase probed by the accessibility of substituted cysteines2006

    • Author(s)
      Sato C, Morohashi Y, Tomita T^*, Iwatsubo T^*
    • Journal Title

      J Neurosci 26

      Pages: 12081-12088

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Concise and short synthesis of functionalized 5, 6-Dihydropyridin-2-ones by means of palladium (0)-catalyzed cross-coupling of ketene aminal phosphates2006

    • Author(s)
      Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M^*
    • Journal Title

      Heterocycles 70

      Pages: 101-106

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver2006

    • Author(s)
      Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T
    • Journal Title

      Pharmaceut Res 23

      Pages: 1407-1416

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Aph-1 contributes to the stabilization and trafficking of the y-secretase complex through mechanisms involving inter-and intramolecular interactions2005

    • Author(s)
      Niimura M
    • Journal Title

      J Biol Chem 280

      Pages: 12967-12975

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Association of active γ-secretase complex with lipid rafts2005

    • Author(s)
      Urano Y
    • Journal Title

      J Lipid Res 46

      Pages: 904-912

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling2005

    • Author(s)
      Takeda T
    • Journal Title

      FASEB Journal 19

      Pages: 2069-2071

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Pen-2 is incorporated into the γ-secretase complex through binding to transmembrane domain 4 of presenilin 12005

    • Author(s)
      Watanabe N
    • Journal Title

      J Biol Chem 280

      Pages: 41967-41975

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils.2005

    • Author(s)
      Osada Y
    • Journal Title

      J Biol Chem 280

      Pages: 8596-8605

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Aph-1 contributes to the stabilization and trafficking of the γ-secretase complex through mechanisms involving inter-and intramolecular interactions2005

    • Author(s)
      Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T^*, Iwatsubo T^*
    • Journal Title

      J Biol Chem 280

      Pages: 12967-12975

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of active γ-secretase complex with lipid rafts2005

    • Author(s)
      Drano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T^*, Kodama T
    • Journal Title

      J Lipid Res 46

      Pages: 904-912

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling2005

    • Author(s)
      Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakavama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, Donoviel DB, Bernstein A, Tomita T, Iwatsubo T, Hori M, Otsu K^*
    • Journal Title

      FASEB J. 19

      Pages: 2069-2071

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Pen-2 is incorporated into the γ-secretase complex through binding to transmembrane domain 4 of presenilin 12005

    • Author(s)
      Watanabe N, Tomita T^*, Sato C, Kitamura T, Morohashi Y, Iwatsubo T^*
    • Journal Title

      J Biol Chem 280

      Pages: 41967-41975

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils2005

    • Author(s)
      Osada Y, Hashimoto T, Nishimura A, Matsuo Y Wakabayashi T, Iwatsubo T.
    • Journal Title

      J Biol Chem 280

      Pages: 8596-8605

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structure and function of γ-secretase2008

    • Author(s)
      Iwatsubo T
    • Organizer
      Keystone symposia
    • Place of Presentation
      Keystone
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Alzheimer's disease: β-amyloid and γ-secretase.2008

    • Author(s)
      Iwatsubo T
    • Organizer
      10th International Hong Kong/Springfield Symposium on Advances in Alzheimer Therapy
    • Place of Presentation
      Hong-Kong
    • Year and Date
      2008-03-01
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Alzheimer's disease : β-amyloid and γ-secretase2008

    • Author(s)
      Iwatsubo T
    • Organizer
      10th International Hong Kong/Springfield Symposium on Advances in Alzheimer Therapy
    • Place of Presentation
      Hong-Kong
    • Year and Date
      2008-03-01
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Molecular pathology of Alzheimer's disease: β-amyloid and γ-secretase.2007

    • Author(s)
      Iwatsubo T
    • Organizer
      Japan-Korea Neuroscience Symposium
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Molecular pathology of Alzheimer's disease : β-amyloid and γ-secretase2007

    • Author(s)
      Iwatsubo T
    • Organizer
      Japan-Korea Neuroscience Symposium
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Molecular pathology of Alzheimer's disease: from benchside to clinics.2007

    • Author(s)
      Iwatsubo T
    • Organizer
      The 4th retreat of 21st century COE on brain medicine of the University of Tokyo
    • Place of Presentation
      Hakone
    • Year and Date
      2007-07-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Molecular pathology of Alzheimer's disease : from benchside to clinics2007

    • Author(s)
      Iwatsubo T
    • Organizer
      The 4th retreat of 21st century COE on brain medicine of the University of Tokyo
    • Place of Presentation
      Hakone
    • Year and Date
      2007-07-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Molecular pathology of Alzheimer's disease: focusing on Aβ and γ-secretase.2007

    • Author(s)
      Iwatsubo T
    • Organizer
      Workshop on Alzheimer's disease and Parkinson's disease. RIKEN BSI
    • Place of Presentation
      Wako
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Molecular pathology of Alzheimer's disease : focusing on Aβ and γ-secretase2007

    • Author(s)
      Iwatsubo T
    • Organizer
      Workshop on Alzheimer's disease and Parkinson's disease. RIKEN BSI
    • Place of Presentation
      Wako
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] γ-Secretase: Structure and Function.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Ringberg symposium on regulated membrane proteolysis
    • Place of Presentation
      Ringberg
    • Year and Date
      2006-11-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] γ-Secretase : Structure and Function2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Ringberg symposium on regulated membrane Proteolysis
    • Place of Presentation
      Ringberg
    • Year and Date
      2006-11-29
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Alzheimer's disease: β-amyloid and γ-secretase as therapeutic targets.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      The 4th COE international symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Alzheimer's disease : β-amyloid and γ-secretase as therapeutic targets2006

    • Author(s)
      Iwatsubo T
    • Organizer
      The 4th COE international symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Challenges for the enigma of Aβ and γ-secretase.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Alzheimer 100 years and beyond
    • Place of Presentation
      Tuebingen
    • Year and Date
      2006-11-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Challenges for the enigma of Aβ and γ-secretase2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Alzheimer 100 years and beyond
    • Place of Presentation
      Tuebingen
    • Year and Date
      2006-11-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Molecular pathology of Alzheimer's disease: β -amyloid and γ-secretase.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Wellcome Trust/CSHL Course Molecular Neurology and Neuropathology Lecture
    • Place of Presentation
      Cambridge
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] γ-Secretase.2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Alzforum Tenth Anniversary Symposium. 10th International Meeting on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structure and Function of presenilin. Demonstration of a water-accessible pore within γ-secretase by SCAM analysis.2006

    • Author(s)
      lwatsubo T
    • Organizer
      10th International Meeting on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid
    • Year and Date
      2006-07-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structure and Function of presenilin. Demonstration of a water-accessible pore within γ-secretase by SCAM analysis2006

    • Author(s)
      Iwatsubo T
    • Organizer
      10th International Meeting on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid
    • Year and Date
      2006-07-17
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] g-Secretase2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Alzforum Tenth Anniversary Symposium 10th International Meeting on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid
    • Year and Date
      2006-07-17
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Molecular pathology of Alzheimer's disease : β-amyloid and γ-secretase2006

    • Author(s)
      Iwatsubo T
    • Organizer
      Wellcome Trust/ CSHL Course Molecular Neurology and Neuropathology Lecture
    • Place of Presentation
      Cambridge
    • Year and Date
      2006-07-02
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structure and Function of presenilin. Demonstration of a water-accessible pore within γ-secretase by SCAM analysis.2005

    • Author(s)
      Iwatsubo T
    • Organizer
      The 3rd Takeda Science Foundation Symposium on PharmaSciences: On the Frontiers of Neuro-PharmaSciences-Molecular Pathology and Drug Action
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-12-05
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Molecular Pathology of Alzheimer's disease : β-amyloid and γ-secretase2005

    • Author(s)
      Iwatsubo T
    • Organizer
      The 3rd Takeda Science Foundation Symposium on PharmaSciences : On the Frontiers of Neuro-PharmaScie-Molecular Pathology and DrugAction
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-12-05
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structure and function of γ-secretase.

    • Author(s)
      Iwatsubo T
    • Organizer
      Keystone symposia, Alzheimer's disease
    • Description
      「研究成果報告書概要(和文)」より
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.f.u-tokyo.ac.jp/~neuropsc/index.html

URL: 

Published: 2010-02-04  

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