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2007 Fiscal Year Final Research Report Summary

Development of Green Chemistry-oriented Analytical Method for Environmental and Waste Samples by Nano/Micro LC/MS

Research Project

Project/Area Number 17201020
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental technology/Environmental materials
Research InstitutionChubu University (2006-2007)
National Institute for Environmental Studies (2005)

Principal Investigator

SUZUKI Shigeru  Chubu University, Graduate School of Bioscience and Biotechnology, Professor (00343757)

Co-Investigator(Kenkyū-buntansha) SHIBATA Yasuyuki  National Institute for Environmental Studies, Environmental Chemistry Division, Senior Chief Researcher (80154251)
Project Period (FY) 2005 – 2007
KeywordsNano / Micro LC / MS / SOLUTE FOCUSING TECHNIQUE / IONIZATION METHOD BY EXCITED ARGON / HIGHLY HYDROPHOBIC COMPOUNDS / Environmental and Waste Samples
Research Abstract

Micro liquid chromatography/mass spectrometry (LC/MS) can contribute green chemistry by saving solvent and reducing waste. However micro LC/MS was mostly ineffective for measuring highly hydrophobic compounds, in particular for small molecules. We developed a micro LC/MS method for measuring hydrophobic and small molecular mass compounds of environmental interest. The method includes solute focusing technique in micro LC and an ionization method by excited argon for mass spectrometry.
Solute focusing was successfully performed for highly hydrophobic compounds by dynamically diluting hydrophobic solution with hydrophilic solution in micro mixer upstream of analytical micro column. In case of O-(4-cyano-2-ethoxybenzyl) hydroxylamine (CNET) derivatives of aldehyde homologues in acetone, theoretical plate numbers of the peaks were ranged 27, 000to 60, 000 when 5uL of the solution in 0.2to 10ppb were injected. Working curves of those compounds were mostly linear with good regression.
Ionization by excited argon was efficient for some hydrophobic compounds. It generated M+'ion with high signal to noise ratio (s/n) from butanone, of which the ionization energy (I.E.) and the proton affinity (PA) are 9.52eV and 827.3kJ/mol, respectively. M+'ion and MH+ ion generated from picoline (I.E.: 9.26eV, PA: 949.1kJ/mol) were respectively 8 and 30 times higher in s/n than those from Atmospheric Pressure Chemical Ionization(APCI).
Through this study, a way to save and reduce organic solvents, which contribute green chemistry in environmental and waste analysis, was developed

  • Research Products

    (6 results)

All 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] 環境分析におけるマススペクトロメトリー2007

    • Author(s)
      鈴木 茂
    • Journal Title

      J.Mass Spectrom.Soc.Jpn. 55

      Pages: 117-125

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Mass Spectrometry in Environmental Analysis2007

    • Author(s)
      Shigeru Suzuki
    • Journal Title

      J. Mass Spectrom. Soc. Jpa. 55

      Pages: 117-125

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] SOLUTE FOCUSING TECHNIQUE AND IONIZATION METHOD BY EXCITED ARGON FOR ANALYZING HIGHLY HYDROPHOBIC COMPOUNDS OF ENVIRONMENTAL INTEREST BY MICRO MICRO LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY2008

    • Author(s)
      S.Suzuki
    • Organizer
      the 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers
    • Place of Presentation
      The Conference Center Site Oud Sint-Jan,Brugge,Belgium
    • Year and Date
      20080128-0201
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] SOLUTE FOCUSING TECHNIQUE AND IONIZATION METHOD BY EXCITED ARGON FOR ANALYZING HIGHLY HYDROPHOBIC COMPOUNDS OF ENVIRONMENTAL INTEREST BY MICRO LIQUIDCHROMATOGRAPHY/MASS SPECTROMETRY2008

    • Author(s)
      S. Suzuki, A. Hasegawa, M. Uebori, Y. Yoshida, S. Shibata, M. Yoshikane
    • Organizer
      the 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers
    • Place of Presentation
      Brugge, Belgium
    • Year and Date
      20080128-0201
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] DEVELOPMENT OF A HIGHLY-SENSITIVE MICRO-LC/MS/MS METHOD FOR THE ELUCIDATION OF TOXICOKINETICS OF DIPHENYL ARSENIC ACID IN CENTRAL NERVOUS SYSTEM2007

    • Author(s)
      M.Yoshikane
    • Organizer
      1st International Symposium on Metallomics 2007
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] DEVELOPMENT OF A HIGHLY-SENSITIVE MICRO-LC/MS/MS METHOD FOR THE ELUCIDATION OF TOXICOKINETICS OF DIPHENYL ARSENIC ACID IN CENTRAL NERVOUS SYSTEM2007

    • Author(s)
      M. Yoshikane, Y. Shibata, S. Suzuki
    • Organizer
      1st International Symposium on Metallomics 2007
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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