2007 Fiscal Year Final Research Report Summary
Study for involvement of lipid glycation in food deterioration and living senescence
| Project/Area Number |
17208011
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
MIYAZAWA Teruo Tohoku University, Graduate School of Agricultural Science, professor (20157639)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAKAWA Hitoshi Tohoku University, Graduate School of Agricultural Science, Associate Professor (40206280)
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| Project Period (FY) |
2005 – 2007
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| Keywords | lipid glycation / hyperglycemia / Amadori-glycated PE / food quality / chemical structure analysis / lipid peroxidation / angiogenesis molecular / lipid glycation inhibitor |
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| Research Abstract |
Although Maillard reaction (glycation) between protein and glucose has been thoroughly investigated, we have found that it is possible for glycation to occur between lipid and glucose in food and biological materials. The objective of this research is following; to elucidate whether lipid glycation associate with lipid peroxidation and cellular dysfunction, and to find the food component that able to inhibit lipid glycation.
(1) The analysis of alteration of food quality/nutrition value/function by lipid glycation.
Processed foods (infant formula, mayonnaise, chocolate) contained a significant amount of Amadori-PEs. As these foods have high amounts of sugar and lipids, lipid glycation would occur during heat processing of these products. Then, various compounds were evaluated for their antiglycative properties using the lipid glycation model system. Pyridoxal 5'-phosphate (PLP) was the most effective antiglycative compounds. PLP could easily be condensed with PE before the glucose/PE rea
… More
ction occurred. Moreover, oral dose of PLP could effectively prevent the abnormal accumulation of Amadori-PE in the STZ-induced diabetic rats.
(2) Ion-trap tandem mass spectrometric analysis of Amadori-glycated phosphatidylethanolamine in human plasma with or without diabetes.
We developed an analysis method of Amadori-PE using a quadrupole/linear ion-trap mass spectrometer, the Applied Biosystems QTRAP. Amounts of Amadori-PE in plasma of diabetic patients (0.15 mol% of PE), diabetic patients with chronic hemodialysis (0.29 mol% of PE), and nondiabetic patients with chronic hemodialysis (0.13 mol% of PE) are higher than that of the control group (0.08 mol% of PE). In addition, the concentration of Amadori-PE was proportional to that of phosphatidylcholine hydroperoxide, a reliable indicator of membrane lipid peroxidation, in human plasma (P<0.05). These results indicate that plasma Amadori-PE-glycated lipid product formed under hyperglycemic conditions is an inducer of membrane lipid peroxidation, and therefore lipid glycation plays an active part in the development of human disease. Less
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Research Products
(158 results)
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[Journal Article] Current topics in food and biodynamic chemistry research.2006
Author(s)
T. Miyazawa, Y. Kawakami, T. Kimura, Y. Suzuki, S. Yamashita, R. Abe, D. Ibusuki, P. Sookwong, T. Tsuzuki, F. Kimura, K. Nakagawa
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Journal Title
Tohoku Journal of Agricultural Research 57
Pages: 33-54
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Current topics in food and biodynamic chemistry research2006
Author(s)
TT. Miyazawa, Y. Kawakami, T. Kimura, Y. Suzuki, S. Yamashita, R. Abe, D. Ibusuki, P. Sookwong, T. Tsuzuki, F. Kimura, K. Nakagawa
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Journal Title
Tohoku Journal of Agricultural Research 57
Pages: 33-54
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Antiangiogenic Potency of Tocotrienol2007
Author(s)
T. Miyazawa, A. Shibata, K. Nakagawa, T. Tsuzuki
Organizer
98th AOCS Annual-Meeting & Expo (A Joint World Congress with the JOCS)
Place of Presentation
Quebec, Canada
Year and Date
20070513-20070516
Description
「研究成果報告書概要(和文)」より
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[Presentation] Antiangiogenic Potency of Tocotrienol.2007
Author(s)
T. Miyazawa, A. Shibata, K. Nakagawa, T. Tsuzuki
Organizer
98th AOCS Annual Meeting & Expo (A Joint World Congress with the JOCS)
Place of Presentation
Quebec, Canada
Year and Date
20070513-20070516
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 食品脂質のグリケーション2006
Author(s)
仲川清隆, 宮澤陽夫
Organizer
第45回日本油化学会年会
Place of Presentation
東京理科大学(野田市)
Year and Date
20060908-20060910
Description
「研究成果報告書概要(和文)」より
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[Book] 食品の科学2005
Author(s)
宮澤陽夫
Total Pages
108-114
Publisher
東京化学同人
Description
「研究成果報告書概要(和文)」より
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[Book] 脂質栄養と健康2005
Author(s)
宮澤陽夫, 都築毅, 仲川清隆
Total Pages
41-59
Publisher
建帛社
Description
「研究成果報告書概要(和文)」より
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[Book] 食品機能素材32005
Author(s)
宮澤陽夫
Total Pages
34-42
Publisher
シーエムシー出版
Description
「研究成果報告書概要(和文)」より
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