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2007 Fiscal Year Final Research Report Summary

Research on the pathogenesis, clinical features, diagnostic methods and treatment of acute encephalitis/encephalopathy.

Research Project

Project/Area Number 17209037
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionOkayama University

Principal Investigator

MORISHIMA Tsuneo  Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Professor (90157892)

Co-Investigator(Kenkyū-buntansha) OKABE Nobuhiko  Okayama University, Infectious Disease, Surveillance Center, National Institute of Infectious Diseases, Director (10057028)
NUNOI Hiroyuki  University of Miyazaki, Faculty of Medicine, Professor (50218260)
MIZUGUCHI Masashi  the University of Tokyo, Graduate School of Medicine, Professor (20209753)
KIMURA Hiroshi  Nagoya University, Graduate School of Medicine, Assistant Professor (30303621)
ICHIYAMA Takashi  Yamaguchi University, Graduate School of Medicine, Lecture (20263767)
Project Period (FY) 2005 – 2007
Keywordsacute encephalitis / acute encephalopathy / influenza / HHV-6 / rotavirus / pathogenesis
Research Abstract

The annual incidence of acute encephalitis/encephalopathy among children younger than 15 years old is approximately 1,000 cases and 25% of them are influenza-associated encephalopathy, followed by encephalopathy/encephalitis caused by HHV-6 or 7 (12%), mumps and rotavirus CNS encephalitis/encephalopathy (4-5%). Although the pathogenesis of influenza-associated encephalopathy is still unclear, several reports have suggested that the pathogenesis involves cytokines such as soluble tumor necrosis factor (sTNF) receptor-1, interleukin-1β (IL-1β), IL-6, TNF-a, IL-8, and IL-10. It has been suggested that neurons and hepatocytes are induced to undergo apoptosis in influenza-associated encephalopathy as a consequence of hypercytokinemia. In contrast, the pathogenesis of other viral encephalitis/encephalopathy is still unclear. In rotavirus encephalopathy, the virus replication could not be found in the brain, while severe brain and lung edema was found associated with hyper cytokinemia. Therefore, not only in influenza but in other virus infections, brain damage may occur due to hyper cytokinemia without virus replication. These findings might be important for the management of the illness. In addition, we could develop multiplex PCR system for the early diagnosis of HSV encephalitis, HHV-6 encephalopathy and EBV CNS infections.

  • Research Products

    (15 results)

All 2007 2006 2005

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (2 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Simultaneous quantification of Epstein-Barr virus, Citomegalovirus, and human Herpesvirus 6 DNA in transplant recipients by multiplex real-time PCR assay.2007

    • Author(s)
      Wada K, et al.
    • Journal Title

      J Clin Microbiol 45

      Pages: 1426-1432

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Analysis of Gene Expression Profiles by Oligonucleotide Microarray in Children with Influenza.2006

    • Author(s)
      Kawada J, et al.
    • Journal Title

      J Gen Virol 87

      Pages: 1677-1683

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Prognostic predictive values of serum cytochrome c, cytokines and other laboratory measurements in acute encephalopathy with multiple organ failure.2006

    • Author(s)
      Hosoya M, et al.
    • Journal Title

      Arch Dis Child 91

      Pages: 469-472

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Serum levels of matrix metalloproteinase-9 and its tissue inhibitor (TIMP-1) in acute disseminated encephalomyelitis.2006

    • Author(s)
      Ichiyama T, et al.
    • Journal Title

      J Neuroimmunol 172

      Pages: 182-186

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The mildest form of acute necrotizing encephalopathy associated with in fluenza A.2006

    • Author(s)
      Okumura A, et al.
    • Journal Title

      Neuropediatrics 37 37

      Pages: 261-263

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Serum levels of matrix metalloproteinase-9 and its tissue inhibitor(TIMP-1) in acute disseminated encephalomyelitis.2006

    • Author(s)
      Ichiyama T, et al.
    • Journal Title

      J Neuroimmunol 172

      Pages: 182-186

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The mildest form of acute necrotizing encephalopathy associated with influenza A.2006

    • Author(s)
      Okumura A, et al.
    • Journal Title

      Neuropediatrics 37

      Pages: 261-263

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Rapid detection of herpes simplex virus DNA in cerebrospinal fluid : comparison between loop-mediated isothermal amplification and real-time PCR.2005

    • Author(s)
      Kimura H, et al.
    • Journal Title

      Med Microbiol Immunol 194

      Pages: 181-185

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Analysis of cyokine levels in cerebrospinal fluid in mumps meningitis : comparison with echovirhu type 30 meningitis.2005

    • Author(s)
      Ichiyama T, et al.
    • Journal Title

      Cytokine 30

      Pages: 243-247

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Analysis of serum soluble CD40 ligand in patients with influenza virus-associated encephalopathy2005

    • Author(s)
      Ichiyama T, et al.
    • Journal Title

      J Neurol Sci 239

      Pages: 53-57

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis:comparison with echovirus type 30 meningitis.2005

    • Author(s)
      Ichiyama T, et al.
    • Journal Title

      Cytokine 30

      Pages: 243-247

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Intravenous immunoglobulin inhibits nuclear factor-kappa B actuvation and affects Fcγ recepotr expression in monocytes/macrophages. The 8th International Kawasaki Disease Symposium.2005

    • Author(s)
      Ichiyama T, et al.
    • Organizer
      The 8th International Kawasaki Disease Symposium
    • Place of Presentation
      サンディエゴ
    • Year and Date
      20050217-20050220
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Intravenous immunoglobulin inhibits nuclear factor-kappa B activation and affects Fc γ receptor expression in monocytes/ macrophages. The 8th International Kawasaki Disease Symposium.2005

    • Author(s)
      Ichiyama T, et al.
    • Organizer
      The 8th International Kawasaki Disease Symposium
    • Place of Presentation
      San Diego.
    • Year and Date
      20050217-20050220
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 医学書院東京2006

    • Author(s)
      奥村彰久
    • Total Pages
      872
    • Publisher
      急性脳症、Reye症候群. 今日の小児治療指針第14版
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] ウイルス検出用オリゴヌクレオチドセット、EBV、CMV及びHHV-6の分析方法及び検出キット2006

    • Inventor(s)
      木村宏
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      (特願2006-157532)
    • Filing Date
      2006-06-06
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2010-06-09  

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