Investigation of Langerhans cell stimulatory molecule and its application in skin disease therapy

2008 Fiscal Year Final Research Report

• Project/Area Number: 17209039
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: TAMAKI Kunihiko The University of Tokyo, 医学部・附属病院, 教授 (30010432)
• Co-Investigator(Kenkyū-buntansha): ASAHINA Akihiko 東京大学, 医学部・附属病院, 助教授 (50202601) ; KOMINE Mayumi 東京大学, 医学部・附属病院, 講師 (00282632) ; WATANABE Takahiro 東京大学, 医学部・附属病院, 講師 (30280960) ; TADA Yayoi 東京大学, 医学部・附属病院, 助教 (00334409)
• Project Period (FY): 2005 – 2008
• Keywords: ランゲルハンス細胞 / 樹状細胞 / 共刺激分子

Research Abstract

樹状細胞の成熟を促進する新規遺伝子(GeneA(仮))をマウスランゲルハンス細胞(LC)を用いたcDNAサブトラクション法により見出した。さらにGeneA がCD40の発現を促進し、樹状細胞からのIL-12産生を促進する事により、Th1系反応の誘導に寄与する可能性が示唆された。今後、腫瘍免疫や初期免疫の誘導にGeneAを応用する可能性について引き続き検討して行く。

Research Products

• [Journal Article] CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli (2008)
  • Author(s): Kagami S, Saeki H, Tsunemi Y, Nakamura K, Kuwano Y, Komine M, Nakayama T, Yoshie O, Tamaki K
  • Journal Title: Eur J Immunol 38巻 Pages: 647-657
  • Peer Reviewed
• [Journal Article] CD19 expression in B cells is important for suppression of contact hypersensitivity (2007)
  • Author(s): Watanabe R, Fujimoto M, Ishiura N, Kuwano Y, Nakashima H, Yazawa N, Okochi H, Sato S, Tedder TF, Tamaki K.
  • Journal Title: Am J Pathol 171巻 Pages: 560-570
  • Peer Reviewed
• [Journal Article] The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells (2007)
  • Author(s): Fujita H, Asahina A, Komine M, Tamaki K.
  • Journal Title: Cell Immunol 245巻 Pages: 70-79
  • Peer Reviewed
• [Journal Article] Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts (2007)
  • Author(s): Jinnin M, Ihn H, Mimura Y, Asano Y, Tamaki K.
  • Journal Title: Arthritis Rheum 56巻 Pages: 1694-1705
  • Peer Reviewed
• [Journal Article] Early inflammatory changes in the "perilesional skin" of psoriatic plaques : is there interaction between dendritic cells and keratinocytes (2007)
  • Author(s): Komine M, Karakawa M, Takekoshi T, Sakurai N, Minatani Y, Mitsui H, Tada Y, Saeki H, Asahina A, Tamaki K.
  • Journal Title: J Invest Dermatol 127巻 Pages: 1915-1922
  • Peer Reviewed
• [Journal Article] CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli (2007)
  • Author(s): Tsunemi Y, Saeki H, Nakamura K, Nagakubo D, Nakayama T, Yoshie O, Kagami S, Shimazu K, Kadono T, Sugaya M, Komine M, Matsushima K, Tamaki K
  • Journal Title: Eur J Immunol 36巻 Pages: 2116-2127
  • Peer Reviewed
• [Journal Article] The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers (2006)
  • Author(s): Hoashi T, Muller J, Vieira WD, Rouzaud F, Kikuchi K, Tamaki K, Hearing VJ
  • Journal Title: J Biol Chem 281巻 Pages: 21198-21208
  • Peer Reviewed
• [Journal Article] Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts (2006)
  • Author(s): Asano Y, Ihn H, Yamane K, Jinnin M, Tamaki K
  • Journal Title: Am J Pathol 168巻 Pages: 499-510
  • Peer Reviewed
• [Journal Article] B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation (2006)
  • Author(s): Fujimoto M, Kuwano Y, Watanabe R, Asashima N, Nakashima H, Yoshitake S, Okochi H, Tamaki K, Poe JC, Tedder TF, Sato S.
  • Journal Title: J Immunol 176巻 Pages: 873-879
  • Peer Reviewed
• [Journal Article] Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts (2005)
  • Author(s): Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K
  • Journal Title: J Immunol 175巻 Pages: 7708-7718
  • Peer Reviewed
• [Presentation] Symposium : Basic and Clinical Allergology (2007)
  • Author(s): Tamaki K
  • Organizer: World Congress of Dermatology
  • Place of Presentation: Buenos Aires Argentina
  • Year and Date: 20071001-05
• [Presentation] Invited lecture : Langerhans cells and Toll-like receptors (2007)
  • Author(s): Tamaki K
  • Organizer: 10^<th> International Workshop on Langerhans cells
  • Place of Presentation: Bern, Switzerland
  • Year and Date: 20070902-04