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2007 Fiscal Year Final Research Report Summary

Development of diagnosis and treatment method of man sterility based on analyses of spermatogenesis-assaciatal genes

Research Project

Project/Area Number 17209052
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

TANAKA Hiromitsu  Osaka University, Research Institute for Microbial Diseases, Assistant Professor (10263310)

Co-Investigator(Kenkyū-buntansha) OKUYAMA Akihiko  Osaka University, Graduate School of Medicine, Professor (20093388)
TSUJIMURA Akira  Osaka University, Graduate School of Medicine, Associate Professor (40294053)
MIYAGAWA Yasushi  Osaka University, Graduate School of Medicine, Assistant Professor (70362704)
Project Period (FY) 2005 – 2007
KeywordsTestis / Sperm / male infertilit / Development / gene / protein / Specific / Treatment
Research Abstract

As many as 15% of couples are unable to conceive, and males are known to be responsible for half of the instances of infertility. Although advances in medical technology have allowed some infertile couples to have children, the causes of infertility are, in most cases, unknown. Many genes are expressed exclusively in the testes, particularly in the testicular germ cells. It is reasonable to propose that functional deficiencies in the genes expressed exclusively in spermatogenesis should lead to male infertility when there is no observable abnormality in the somatic cells of various organs. Hence, in order to understand idiopathic male infertility, development of diagnosis and treatment method of male infertility based on analyses of spermatogenesis-associated genes is essential. In this study, we found infertility specific protein in human semen and identified polymorphisms associated with male infertility in human haploid germ cell specific genes.

  • Research Products

    (87 results)

All 2008 2007 2006 2005 Other

All Journal Article (62 results) (of which Peer Reviewed: 13 results) Presentation (17 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Isolation and Characterization of the Haploid Germ Cell-Specific Smrpl Gene for a Novel Manchette Protein in the Mouse.2008

    • Author(s)
      Matsuoka Y., et. al.(他11名)
    • Journal Title

      Mol. Reprod. Dev. 75

      Pages: 967-975

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Taip2 is a novel cell death-related gene expressed in the brain during development.2008

    • Author(s)
      Yamada K., et. al.(他6)
    • Journal Title

      Biochem. Biophys. Res. Commun. 369

      Pages: 426-431

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Relationship between the substances in seminal plasma and the Acrobeads test[○!R].2008

    • Author(s)
      Komori K., et. al.(他8)
    • Journal Title

      Fertil. & Steril. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Nitric Oxide synthesis leads to Vascular Endothelial Growth Factor Synthesis via the NO/Cyclic Guanosine 3', 5'-Monophosphate(cGMP)Pathway in Human Corpus Cavernosal Smooth Muscle Cells.2008

    • Author(s)
      Komori K., et. al.(他7)
    • Journal Title

      J. Sex. Med. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Androgen Decline in Patients with Nonobstructive Azoospemia After Microdissection Testicular Sperm Extraction.2008

    • Author(s)
      Takada S., et. al.(他12)
    • Journal Title

      Urology. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Meichroacidin containing the MORN motif is essential for spermatozoa morphogenesis.2008

    • Author(s)
      Tokuhiro K., et. al.(他16)
    • Journal Title

      J Biol Chem. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Isolation and Characterization of the Haploid Germ Cell-Specific Smrp1 Gene for a Novel Manchette Protein in the Mouse2008

    • Author(s)
      Matsuoka, Y, Miyagawa, Y, Tokuhiro, K, Kitamura, K, Iguchi, N, Maekawa, M, Takahashi, T, Tsujimura, A, Matsumiya, K, Okuyama, A, Nishimune, Y, Tanaka, H
    • Journal Title

      Mol Reprod Dev 75

      Pages: 967-975

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Taip2 is a novel cell death-related gene expressed in the brain during development2008

    • Author(s)
      Yamada, K, Akiyama, N, Yamada, S, Tanaka, H, Saito, S, Hiraoka, M, Kizaka-Kondoh, S
    • Journal Title

      Biochem Biophys Res Commun 369

      Pages: 426-431

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Comprehensive analysis of gene expression in testes producing haploid germ cell susing DNA microarray analysis.2007

    • Author(s)
      Ike A., et. al.(他5)
    • Journal Title

      Int. J. Androl. 30

      Pages: 462-475

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The 193-Base Pair Gsg2(Haspin)Promoter Region Regulates Germ Cell-Specific Expression Bidirectionally and Synchronously.2007

    • Author(s)
      Tbkuhiro k., et. al.(他6)
    • Journal Title

      Biol. Reprod. 76

      Pages: 407-414

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Production of Functional Spematids from Mouse Germline Stem Cells in Ectopically Reconstituted Seminiferous Tubules.2007

    • Author(s)
      Kita K., et. al.(他14)
    • Journal Title

      Biol. Reprod. 76

      Pages: 211-217

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Prostatic stem cell marker identified by cDNA microarray in mouse.2007

    • Author(s)
      Tsujimura A., et. al.(他7)
    • Journal Title

      J. Urol. 178

      Pages: 686-691

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Differential brain processing of audiovisual sexual stimuli in men: comparative positron emission tomography study of the iniitiation and maintenance of penile erection during sexual arousal.2007

    • Author(s)
      Miyagawa Y., et. al.(他13)
    • Journal Title

      Neuroimage 36

      Pages: 830-842

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Clinical comparison of successful and failed microdissection TESE in patients with non-mosaic Klinefelter syndrome.2007

    • Author(s)
      Koga M., et. al.(他11)
    • Journal Title

      Urology 70

      Pages: 0341-345

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer.2007

    • Author(s)
      Nonomura N., et. al.(他9)
    • Journal Title

      Br. J. Cancer 97

      Pages: 952-956

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of gene expression in testes producing haploid germ cells using DNA microarray analysis2007

    • Author(s)
      Ike, A, Tokuhiro, K, Hirose, M, Nozaki, M, Nishimune, Y, Tanaka, H
    • Journal Title

      Int J Androl 30

      Pages: 462-475

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The 193-Base Pair Gsg2 (Haspin) Promoter Region Regulates Germ Cell-Specific Expression Bidirectionally and Synchronously2007

    • Author(s)
      Tokuhiro, K, Miyagawa, Y, Yamada, S, Hirose, M, Ohta, H, Nishimune, Y, Tanaka, H
    • Journal Title

      Biol Reprod 76

      Pages: 407-414

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Production of Functional Spermatids from Mouse Germline Stem Cells in Ectopically Reconstituted Seminiferous Tubules2007

    • Author(s)
      Kita, K, Watanabe, T, Obsaka, K, Hayashi, H, Kubota, Y, Nagashima, Y, Aoki, I, Taniguchi, H, Noce, T, Inoue, K, Mild, H, Ogonuki, N, Tanaka, H, Ogura, A, Ogawa, T
    • Journal Title

      Biol Reprod 76

      Pages: 211-217

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prostatic stem cell marker identified by cDNA microarray in mouse2007

    • Author(s)
      Tsujimura, A Fujita, K, Takao, T, Miyagawa, Y, Takada, S, Matsumiya, K, Nonomura, N, Okuyama, A
    • Journal Title

      J. Urol 178

      Pages: 686-691

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differential brain processing of audiovisual sexual stimuli in men : comparative positron emission tomography study of the initiation and maintenance of penile erection during sexual arousal2007

    • Author(s)
      Miyagawa, Y, Tsujimura, A, Fujita, K, Matsuoka, Y, Takahashi, T, Takao, Ti, Takada, S, Matsumiya, K, Osaki, U, Takasawa, M, Oku, M, Hatazawa, J, Kaneko, S, Okuyama, A
    • Journal Title

      Neuroimage 36

      Pages: 830-842

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clinical comparison of successful and failed microdissection TESE in patients with non-mosaic Klinefelter syndrome2007

    • Author(s)
      Koga, M, Tsujimura, A., Takeyama, A, Kiuchi, H, Takao, T, Miyagawa, Y, Takada, S, Matsumiya, K, Fujioka, H, Okamoto, Y, Nonomura, N, Okuyama, A
    • Journal Title

      Urology 70

      Pages: 0341-345

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer2007

    • Author(s)
      Nonomura, N, Takayama, H, Nishimura, K, Oka, D, Nakai, Y, Shiba, M, Tsujimura, A, Nakayama, M, Aozasa, K, Okuyama, A
    • Journal Title

      Br. J. Cancer 97

      Pages: 952-956

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Nitric Oxide synthesis leads to Vascular Endothelial Growth Factor Synthesis via the NO/Cyclic Guanosine 3',5'-Monophosphate (cGMP) Pathway in Human Corpus Cavernosal Smooth Muscle Cells2007

    • Author(s)
      Komori, K., Tsujimura, A., Takao, T., Matsuoka, Y., Miyagawa, Y., Takada, S., Nonomura, N., Okuyama, A
    • Journal Title

      J. Sex. Med, Biol Reprod 76(in press)

      Pages: 407-414

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular biological features of male germ cell differentiation2007

    • Author(s)
      Tanaka, H, Hirose, M, Tokuhiro, K, Tainaka, H, Miyagawa, Y, Tsujimura, A, Okuyama, A, Nishimune, Y
    • Journal Title

      Reprod Med Biol 6

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Single nucleotide polymorphisms : discovery of the genetic causes of male infertility2007

    • Author(s)
      Tanaka, H, Hirose, M, Tokuhiro, K, Matsuoka, Y, Miyagawa, Y, Tsujimura, A, Okuyama, A, Nishimune, Y
    • Journal Title

      Soc Reprod Fertil Suppl 65

      Pages: 531-534

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Microdissection testicular sperm extraction : prediction, outcome, and complications2007

    • Author(s)
      Tsujimura, A
    • Journal Title

      Int J Urol 14

      Pages: 883-889

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Laparoscopic Nephroureterectomy for Upper Tract Transitional Cell Carcinoma : Comparison of Laparoscopic and Open Surgery2006

    • Author(s)
      Tsujihata, M, Nonomura, N, Tsujimura, A, Yoshimura, K, Miyagawa, Y, Okuyama, A
    • Journal Title

      Eur. Urol 49

      Pages: 332-336

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein2006

    • Author(s)
      Tanaka, H, Matsuoka, Y, Onishi, M, Kitamura, K, Miyagawa, Y, Nishimura, H, Tsujimura, A, Okuyama, A, Nishimure, Y
    • Journal Title

      Int. J. Androl 29

      Pages: 353-359

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Laparoscopic adrenalectomy for primary hyperaldosteronism : clinical experience with 60 cases2006

    • Author(s)
      Tsujihata, M, Nonomura, N, Tsujimura, A, Nishimura, K, Yoshimura, K, Okuyama, A
    • Journal Title

      J. Endourol 20

      Pages: 262-265

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Inter/intra-variation in measurements of testicular volumes by ten investigators from five institutions2006

    • Author(s)
      Tatsunami, S, Itoh, N, Nishida, T, Miyano, S, Matsumiya, K, Tsujimura, A, Eguchi, J, Takehara, K, Ko, E, Maeda, Y, Sasao, T, Tabata, C, Iwamoto, T
    • Journal Title

      Asian J. Androl 8

      Pages: 373-378

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A case of renal cell carcinoma with multiple lung metastasis refractory to interferon-a showing complete remission by interleukin-2 monotherapy2006

    • Author(s)
      Hayashi, T, Miyagawa, Y, Tsujimura, A, Nonomura, N, Minami, M, Okuyama, A
    • Journal Title

      Int. J. Urol 13

      Pages: 805-808

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Comparative Study of Sperm Motility Analysis System[○!R] (SMAS[○!R]) and Conventional Microscopic Semen Analysis2006

    • Author(s)
      Komori, K, Tsujimura, A, Ishijima, S, Tanjapatku, P, Fujita, K, Matsuoka, Y, Takao, T, Miyagawa, Y, Takada, S, Okuyama, A
    • Journal Title

      Reprod. Med. & Biol 5

      Pages: 195-200

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Efficacy and safety of tadalafil 5, 10, and 20mg in Japanese men with erectile dysfunction : Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Study2006

    • Author(s)
      Nagao, K, Kimoto, Y, Marumi, K, Tsujimura, A, Vail, G. M., Watts, S, Ishii, N, Kamidono, S
    • Journal Title

      Urology 68

      Pages: 845-851

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Isolation of germ cells from leukemia and lymphoma cells in a human/ in vitro/ model : potential clinical application for restoring human fertility after anticancer therapy2006

    • Author(s)
      Fujita, K, Tsujimura, A, Miyagawa, Y, Kiuchi, H, Matsuoka, Y, Takao, T, Takada, S, Nonomura, N, Okuyama, A
    • Journal Title

      Cancer Res 66

      Pages: 11166-11671

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Brain processing of audiovisual sexual stimuli inducing penile erection : A positron emission tomography study2006

    • Author(s)
      Tsujimura, A, Miyagawa, Y, Fujita, K, Matsuoka, Y, Takahashi, T, Takao, T, Matsumiya, K, Osaki, Y, Takasawa, M, Oku, N, Hatazawa, J, Kaneko, S, Okuyama, A
    • Journal Title

      J. Urol 176

      Pages: 679-683

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Rare case of aggressive angiomyxoma presenting as a retrovesical tumor2006

    • Author(s)
      Hatano, K., Tsujimoto, Y., Ichimaru, N., Miyagawa, Y., Nonomura, N., Okuyama, A
    • Journal Title

      Int. J. Urol 13

      Pages: 1012-4

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of Mina53, a product of a Myc target gene in mouse testis2006

    • Author(s)
      Tsuneoka, M, Nishimune, Y, Ohta, K, Teye, K, Tanaka, H, Soejima, M, Iida, H, Inokuchi, T, Kimura, H, Koda, Y
    • Journal Title

      Int J Androl 29

      Pages: 323-330

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mitochondria-related male infertility2006

    • Author(s)
      Nakada, K, Sato, A, Yoshida, K, Morita, T, Tanaka, H, Inoue, S, Yonekawa, H, Hayashi, J
    • Journal Title

      Proc Natl Acad Sci U S A 103

      Pages: 15148-15153

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis2006

    • Author(s)
      Fraisl, P, Tanaka, H, Forss-Petter, S, Lassmann, H, Nishimune, Y, Berger, J. A
    • Journal Title

      Arch Biochem Biophys 451

      Pages: 23-33

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Infertility Caused by Polymorphisms or Mutations in Spermatogenesis-Specific Genes2006

    • Author(s)
      Nishimune, Y, Tanaka, H
    • Journal Title

      J Androl 27

      Pages: 326-334

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Vascular endothelial growth factor restores erectile function through an inhibition of apoptosis in diabetic rat penile crura2005

    • Author(s)
      Yamanaka, M, Shirai, M, Shiina, H, Tanaka, Y, Enokida, H, Tsujimura, A, Matsumiya, K, Okuyama, A, Dahiya, R
    • Journal Title

      J. Urol 173

      Pages: 318-323

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at University-affiliated male infertility centers : A 30-years retrospective study2005

    • Author(s)
      Miyagawa, Y, Tsujimura, A, Matsumiya, K, Takao, T, Tohda, A, Koga, M, Takeyama, M, Fujioka, H, Takada, S, Koide, T, Okuyama, A
    • Journal Title

      J. Urol 173

      Pages: 2072-2075

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of inhibin alpha, GDNF and SCF in Sertoli cell-only syndrome : relation to successful sperm retrieval by microdissection testicular sperm extraction2005

    • Author(s)
      Fujita, K, Tsujimura, A, Takao, T, Miyagawa, Y, Matsumiya, K, Koga, M, Takeyama, M, Fujioka, H, Aozasa, K, Okuyama, A
    • Journal Title

      Hum. Reprod 20

      Pages: 2289-2294

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Isolation and transplantation of spermatogonial stem cells for treatment of azoospermia after chemotherapy in a leukemic mouse model2005

    • Author(s)
      Fujita, K, Ohta, H, Tsujimura, A, Takao, T, Miyagawa, Y, Takada, S, Matsumiya, K, Wakayama, T, Okuyama, A
    • Journal Title

      Hum. Reprod 20

      Pages: 2289-2294

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Sperm flagella protein components : Human meichroacidin constructed by the MORN motif2005

    • Author(s)
      Matsuoka, Y, Nishimura, H, Numazawa, K, Tsuchida, J, Miyagawa, Y, Tsujimura, A, Matsumiya, K, Okuyama, A, Nishimune, Y, Tanaka, H
    • Journal Title

      Reprod. Med. & Biol 4

      Pages: 213-219

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations2005

    • Author(s)
      Miyagawa, Y, Nishimura, H, Tsujimura, A, Matsuoka, Y, Matsumiya, K, Okuyama, A, Nishimune, Y, Tanaka, H
    • Journal Title

      J. Androl 26

      Pages: 779-786

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Impact of age, FSH and Johnsen's score on successful sperm retrieval by microdissection testicular sperm extraction2005

    • Author(s)
      Tsujimura, A, Miyagawa, Y, Takao, T, Fujita, K, Komori, K, Matsuoka, Y, Takada, S, Koga, M, Takeyama, M, Fujioka, H, Matsumiya, K, Okuyama, A
    • Journal Title

      Reprod. Med. & Biol 4

      Pages: 53-57

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Comparative study on evaluation methods for serum testosterone level for PADAM diagnosis2005

    • Author(s)
      Tsujimura, A, Matsumiya, K, Miyagawa, Y, Takao, T, Fujita, K, Takada, S, Koga, M, Iwasa, A, Takeyama, M, Okuyama, A
    • Journal Title

      Int. J. Imp. Res 17

      Pages: 259-263

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Human chorionic gonadotropin treatment for PADAM : A preliminary report2005

    • Author(s)
      Tsujimura, A, Matsumiya, K, Takao, T, Miyagawa, Y, Takada, S, Koga, M, Iwasa, S, Takeyama, M, Okuyama, A
    • Journal Title

      Aging Male 8

      Pages: 175-179

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Retroperitoneoscopic living related-donor nephrectomy : clinical outcomes of 50 consecutive cases and comparison with open donor nephrectomy2005

    • Author(s)
      Yoshimura, K, Takahara, S, Kyakuno, M, Yamaguchi, S, Yoshioka, T, Miyake, O, Tsujihata, M, Ichimaru, N, Miyagawa, Y, Imamura, R, Okuyama, A
    • Journal Title

      J. Endourol 19

      Pages: 808-12

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association study of homologous RNA-binding-motif-gene on X chromosome (RBMX) and like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia. Asian J. Androl. 8(2) : 213-82005

    • Author(s)
      Tsujimura, A., Fujita, K., Komori, K., Miyagawa, Y., Takada, S., Matsumiya, K., Sada, M., Katsuyama, Y., Ota, M., Okuyama, A
    • Journal Title

      Asian J. Androl 8(2)

      Pages: 213-218

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Salvage microdissection testicular sperm extraction after failed conventional TESE for patients with non-obstructive azoospermia2005

    • Author(s)
      Tsujimura, A., Miyagawa, Y., Takao, T., Takada, S., Koga, M., Takeyama, M., Matsumiya, K., Fujioka, H., Okuyama, A
    • Journal Title

      J. Urol 175(4)

      Pages: 1446-1495

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway2005

    • Author(s)
      Nagamori, I, Yabuta, N, Fujii, T, Tanaka, H, Yomogida, K, Nishimune, Y, Nojima, H
    • Journal Title

      Genes Cells 10

      Pages: 575-594

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Identification of Human HAPRIN Potentially Involved in the Acrosome Reaction2005

    • Author(s)
      Kitamura, K, Nishimura, H, Nishimune, Y, Tanaka, H
    • Journal Title

      J Androl 26

      Pages: 511-518

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of the mammalian sperm2005

    • Author(s)
      Ihara, M, Kinoshita, A, Yamada, S, Tanaka, H, Tanigaki, A, Kitano, A, Goto, M, Okubo, K, Nishiyama, H, Ogawa, O, Takahashi, C, Itohara, S, Nishimune, Y, Noda, M, Kinoshita, M
    • Journal Title

      Developmental Cell 8

      Pages: 343-352

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Brain processing of audiovisual sexual stimuli inducing penile erection : A positron emission tomography study2005

    • Author(s)
      Tsujimura, A., Miyagawa, Y., Fujita, K., Matsuoka, Y., Takahashi, T., Takao, T., Matsumiya, K., Osaki, Y., Takasawa, M., Oku, N., Hatazawa, J., Kaneko, S., Okuyama, A
    • Journal Title

      J. Urol 176

      Pages: 679-83

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Significance of electro stimulation in detecting neurovascular bundle during radical prostatectomy2005

    • Author(s)
      Tsujimura, A., Miyagawa, Y., Takao, T., Matsumiya, K., Nakayama, M., Tsujimoto, Y., Takaha, N., Nishimura, K., Nonomura, N., Takada, T., Fujioka, H., Kurokawa, K., Aozasa, K., Okuyama, A
    • Journal Title

      Int. J. Urol 13(7)

      Pages: 926-31

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The RING-fmger protein Haprin : domains and f niction in the acrosome reaction2005

    • Author(s)
      Kitamura, K, Tanaka, H, Nishimune, Y
    • Journal Title

      CPPS : Current Protein and Peptide Science 6

      Pages: 567-574

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gene expression in spermiogenesis2005

    • Author(s)
      Tanaka, H, Baba, T
    • Journal Title

      CMLS : Cellular and Molecular Life Sciences 62

      Pages: 344-354

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Relationship between the substances in seminal plasma and the Acrobeads test[○!R]

    • Author(s)
      Komori, K., Tsujimura, A., Hirai, T., Okamoto, Y., Matsuoka, Y., Takao, T., Miyagawa, Y., Takada, S., Okuyama, A
    • Journal Title

      Fertil & Steril (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Androgen Decline in Patients with Nonobstructive Azoospemia After Microdissection Testicular Sperm Extraction

    • Author(s)
      Takada, S, Tsujimura, A, Ueda, T, Matsuoka, Y, Takao, T, Miyagawa, Y, Koga, M, Takeyama, M, Okamoto, Y, Matsumiya, K, Fujioka, H, Nonomura, N, Okuyama, A
    • Journal Title

      Urology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Meichroacidin containing the MORN motif is essential for spermatozoa morphogenesis

    • Author(s)
      Tokuhiro, K, Hirose, M, Miyagawa, Y, Tsujimura, A, Irie, S, Isotani, A,Okabe, M, Toyama, Y, Ito, C, Toshimori, K, Takeda, K, Oshio, S, Tainaka, H, Tsuchida, J, Okuyama, A, Nishimune, Y, Tanaka, H
    • Journal Title

      J Biol Chem (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Causal relationship between obesity and dyslipidemia with ED "ED and LUTS/BPH : Possible Relationship with Metabolic Syndrome"2007

    • Author(s)
      Akira, Tsujimura
    • Organizer
      The 11th Biennial Meeting of the Asia Pacific Society for Sexual Medicine
    • Place of Presentation
      Korea
    • Year and Date
      20071000
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Progress of ED research and practice in Asia2007

    • Author(s)
      Tsujimura, Akira
    • Organizer
      The 4th congress of The Asia Pacific Society for the Study of Aging Male
    • Place of Presentation
      Indonesia
    • Year and Date
      20070500
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Progress on invasive management for erectile dysfunction. Main symposium 1"ED & sexual function". Akira Tsujimura2007

    • Author(s)
      Tsujimura, Akira
    • Organizer
      The 4th congress of The The 4th congress of The Asia Pacific Society for the Study of Aging Male
    • Place of Presentation
      Indonesia
    • Year and Date
      20070500
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Progress of ED research and practice in Asia.2007

    • Author(s)
      Akira Tsujimura
    • Organizer
      The 4th congress of The Asia Pacific Society for the Study of Aging Male
    • Place of Presentation
      Indonesia
    • Year and Date
      2007-05-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Progress on invasive management for erectile dysfunction. Main symposium 1 "ED & sexual function.2007

    • Author(s)
      Akira Tsujimura
    • Organizer
      The 4th congress of The Asia Pacific Society for the Study of Aging Male
    • Place of Presentation
      Indonesia
    • Year and Date
      2007-05-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Causal relationship between obesity and dyslipidemia with ED "ED and LUTS/BPH: Possible Relationship with Metabolic Syndrome".2007

    • Author(s)
      Akira Tsujimura
    • Organizer
      The 11th Biennial Meeting of the Asia Pacific Society for Sexual Medicine
    • Place of Presentation
      Korea
    • Year and Date
      2007-05-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Single nucleotide polymorphism (SNP)s discovery of Genetic causes on male fertility2006

    • Author(s)
      Hiromitsu, Tanaka
    • Organizer
      10th International Symposium on Spermatology
    • Place of Presentation
      Madrid
    • Year and Date
      20060900
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Experience from Japan, Symposium "Men's Health in ASEAN-Japan"2006

    • Author(s)
      Akira, Tsujimura
    • Organizer
      The 1st Japan-ASEAN Men's Health and Aging Conference
    • Place of Presentation
      Malaysia
    • Year and Date
      20060600
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Single-Nuceotide Polymorphisms and Mutation Analyses of haploid germ cell-specific genes2006

    • Author(s)
      Hiromitsu, Tanaka
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      20060600
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Salvage microdissection testicular sperm extraction after failed conventional TESE for patients with non-obstructive azoospermia2006

    • Author(s)
      Akira, Tsujimura, Yasushi, Miyagawa, Kazutoshi, Fujita, Tetsuya, Takao, Suita, Masami, Takeyama, Masaki, Yamanaka, Kiyomi, Matsumiya, Hideki, Fujioka, Minoru, Koga, Mino, Akihiko, Okuyama
    • Organizer
      AUA 101th Annual Meeting
    • Place of Presentation
      USA
    • Year and Date
      20060500
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] THE CLINICAL SIGNIFICANCE OF POLYMORPHISMS IN THE PROTAMINE & TRANSITION NUCLEAR PROTAIN GENES IN MALE INFERTILITY2006

    • Author(s)
      Yasushi, Miyagawa, Hiromitsu, Tanaka, Yasuhiro, Matsuoka, Tomohiro, Ueda, Kiuchi, Hiroshi, Phanu, Tanjapatkul, Kazutoshi, Fujita, Kazuhiko, Komori, Tetsuya, Takao, Shingo, Takada, Akira, Tsujimura, Yoshitake, Nishimune, Akihiko, Okuyama
    • Organizer
      AUA 101th Annual Meeting
    • Place of Presentation
      USA
    • Year and Date
      20060500
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Challenging trends in managing metabolic disorders in the Asian Pacific Region.2006

    • Author(s)
      Akira, Tsujimura, Akihikom Okuyama
    • Organizer
      The 5th International Society for Study of Aging
    • Place of Presentation
      Austria
    • Year and Date
      20060200
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Hanp 1/H1T2, a novel histone-like protein involved in the formation of nucleus and the fertility of sperm2005

    • Author(s)
      Hiromitsu, Tanaka
    • Organizer
      International Symposium on Germ Cells, Epigenetics, Reprogramming and Embryonic Stem Cells
    • Place of Presentation
      Kyoto
    • Year and Date
      20051100
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ED with lifestyle disease of aging male in Japan2005

    • Author(s)
      Akira, Tsujimura, Akihiko, Okuyama
    • Organizer
      The 10th Biennial meeting of the Asia Pacific Society for Sexual & Impotence Research
    • Place of Presentation
      Australia
    • Year and Date
      20051000
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Comparative study between sperm motility analysis system and conventional microscopic semen analysis based on WHO laboratory manual2005

    • Author(s)
      Akira, Tsujimura, Kazuhiko, Komori, Kazutoshi, Fujita, Tetsuya, Takao, Yasushi, Miyagawa, Shingo, Takada, Kiyomi, Matsumiya, Akihiko, Okuyama
    • Organizer
      The 8th Intemational Congress of Anthology
    • Place of Presentation
      Korea
    • Year and Date
      20050600
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Identification and Characterization of genes encoding testis-specific proteins involved in making spermatozoa2005

    • Author(s)
      Yoshitake, Nishimune, Hiromitsu, Tanaka
    • Organizer
      8th International Congress ofAndrology
    • Place of Presentation
      Korea
    • Year and Date
      20050600
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] The role of cerebellar activation in the initiation of human penile erection2005

    • Author(s)
      Akira, Tsujimura, Kazutoshi, Fujita, Kazuhiko, Komori, Yasuhiro, Matsuoka, Tohru, Takahashi, Tetsuya, Takao, Shingo, Takada, Kiyomi, Matsumiya, Yasnhiro, Osaki, Naohiko, Oku, Jun, Hatazawa, Akihiko, Okuyama
    • Organizer
      AUA 100th Annual Meeting
    • Place of Presentation
      USA
    • Year and Date
      20050500
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 蛋白質核酸酵素2007

    • Author(s)
      田中宏光
    • Total Pages
      2116-2123
    • Publisher
      共立出版
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Reprod Med Biol2007

    • Author(s)
      Tanaka H
    • Total Pages
      1-9
    • Publisher
      Blackwell Science Asia
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Soc Reprod Fertil Suppl.2007

    • Author(s)
      Tanaka H
    • Total Pages
      531-534
    • Publisher
      Nottingham University Press,
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Int. J. Urol.2007

    • Author(s)
      Tsujimura A
    • Total Pages
      883-889
    • Publisher
      Blackwell Science Asia
    • Description
      「研究成果報告書概要(和文)」より
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.geocities.jp/magical_yellow_boots/

  • [Patent(Industrial Property Rights)] 妊孕性診断キット、変異検出方法、ポリヌクレオチド、ポリペプチド、発現ベクター、及び発現キット2007

    • Inventor(s)
      田中宏光, 西宗義武, 奥山明彦, 辻村晃, 宮川康
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      特願2007-082574号
    • Filing Date
      2007-03-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] 妊孕性診断キット、変異検出方法、ポリヌクレオチド、ポリペプチド、発現ベクター、及び発現キット2007

    • Inventor(s)
      田中宏光, 西宗義武, 奥山明彦, 辻村晃, 宮川康, 入江新司
    • Industrial Property Rights Holder
      大阪大学凸版印刷
    • Industrial Property Number
      特願2007-184946(特願2007-050384の国内優先権主張出願)
    • Filing Date
      2007-07-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] マウス精子形成遺伝子とヒト男性不妊関連遺伝子、ならびにこれらを用いた診断システム2007

    • Inventor(s)
      西宗義武, 田中宏光, 野崎正美
    • Industrial Property Rights Holder
      科学技術振興事業団
    • Industrial Property Number
      PCT/JPO3/01572
    • Acquisition Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Overseas

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Published: 2010-02-04  

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