2006 Fiscal Year Final Research Report Summary
Clinical trial of SE36 malaria vaccine in the endemic area
| Project/Area Number |
17256003
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Osaka University |
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Principal Investigator |
HORII Toshihiro Osaka University, Research Institute for Microbial Diseases, Professor, 微生物病研究所, 教授 (80142305)
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| Co-Investigator(Kenkyū-buntansha) |
ARISUE Nobuko Osaka University, Research Institute for Microbial Diseases, Research Associate, 微生物病研究所, 助手 (00242339)
TAI Kumiko Osaka University, Research Institute for Microbial Diseases, Technical Official, 微生物病研究所, 教務職員 (00187907)
ISHIBASHI Masahide THE Research Foundation for Microbial Diseases of Osaka University, Kanonji Institute, Director, 観音寺研究所, 所長(研究職) (70029776)
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| Project Period (FY) |
2005 – 2006
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| Keywords | malaria vaccine / SE36 protein / Plasmodium falciparum / clinical trial / epidemiological research |
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| Research Abstract |
We have been worked for developing SE36 Malaria vaccine. For licensing the vaccine, the clinical trials in the endemic countries are essential. We are planning the place conducting the clinical trials at Apac, northern Uganda where is highly malaria endemic.
We visited MBL (Molecular Biotech Laboratory) in Kampala, Uganda from 26^<th> Sep. to 1^<st> Oct. 2005, and had meeting with Dr.Thomas Egwang, director of MBL for conducting Phase Ib trial. Following up the meeting, From 7th to 10th. Nov. we had an expanded meeting for the trial in WHO-TDR (World Health Organization, Special program for Research and Training in Tropical Diseases) in Geneva. The participants were Dr.J.Karbwang (WHO-TDR), Dr.Z.Reed (WHO-IVR, Initiative for Vaccine Research), Dr.T.Egwang and T.Horii (PI of this grant). In the meeting, we have discussed for the detail plan of Phase Ib trial in Uganda according to the successful results of Phase la trial in Japan.
On the other hand, pregnant malaria is an important issue in malaria infection. The pregnant malaria causes risky malaria symptoms of pregnant women with high blood parasitemia because of immuno suppression by pregnancy and lower body weight of new born baby because of the accumulation of parasites at the palacenta. By collaborating with Dr.Egwang, we have studied the correlation between parasitemia of pregnant women, body weight of new born baby and the antibody titers against SE36 protein. The results revealed the clear negative correlation of the pregnant malaria symptoms and the antibody titer. Blood parasitemia of pregnant women and the body weight of new born baby are lower and normal respectively when the women has higher antibody titer. The result strongly suggests that SE36 malaria vaccine is effective against the pregnant malaria.
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Research Products
(13 results)
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[Journal Article] Pathological role of Toll-like receptor signaling in cerebral malaria.2007
Author(s)
Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S.
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Journal Title
Int Immunol. 19
Pages: 67-79
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Pathological role of Toll-like receptor signaling in cerebral malaria.2007
Author(s)
Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi 0, Hisaeda H, Horii T, Akira S.
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Journal Title
Int Immunol. 19(1)
Pages: 67-79
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.2006
Author(s)
Krungkrai SR, Tokuoka K, Kusakari Y, Inoue T, Adachi H, Matsumura H, Takano K, Murakami S, Mori Y, Kai Y, Krungkrai J, Horii T.
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Journal Title
Acta Crystallograph Sect F Struct Biol Cryst Commun. 62(Pt 6)
Pages: 542-545
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum2006
Author(s)
Krungkrai SR, Tokuoka K, Kusakari Y, Inoue T, Adachi H, Matsumura H, Takano K, Murakami S, Mori Y, Kai Y, Krungkrai J, Horii T.
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Journal Title
Acta Crystallograph Sect F Struct Biol Cryst Commun. 62(Pt 6)
Pages: 542-54
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Toll-Like Receptor 9 Mediates Innate Immune Activation by Malaria Pigment Hemozoin.2005
Author(s)
Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S
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Journal Title
J. Exp. Med. 201(1)
Pages: 19-25
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Toll-Like Receptor 9 Mediates Innate Immune Activation by Malaria Pigment Hemozoin.
Author(s)
Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi 0, Itagaki S, Kumar N, Horii T, Akira S
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Journal Title
J.Exp.Med. 201(1)
Pages: 19-252005
Description
「研究成果報告書概要(欧文)」より
