Computational studies on the development of intracranial aneurysms considering arterial wall remodeling induced by hemodynamics factors

2008 Fiscal Year Final Research Report

• Project/Area Number: 17300138
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University (2006-2008); Tohoku University (2005)
• Principal Investigator: WADA Shigeo Osaka University, 大学院・基礎工学研究科, 教授 (70240546)
• Co-Investigator(Kenkyū-buntansha): TSUBOTA Kenichi 千葉大学, 大学院・工学研究科, 准教授 (10344045) ; TAKAHASHI Akira 東北大学, 大学院・医学系研究科, 教授 (40301048) ; YAMAGUCHI Takami 東北大学, 大学院・医工学研究科, 教授 (30101843) ; MIYAZAKI Hiroshi 大阪大学, 大学院・基礎工学研究科, 准教授 (00263228) ; NAKAMURA Masanori 大阪大学, 臨床医工学融合研究教育センタ, 特任准教授 (20448046) ; KOSHIYAMA Kenichiro 大阪大学, 大学院・基礎工学研究科, 助教 (80467513)
• Project Period (FY): 2005 – 2008
• Keywords: 計算バイオメカニクス / 脳動脈瘤 / 血流 / 血行力学因子 / リモデリング / 細胞力学試験 / ルールベースト・シミュレーション

Research Abstract

脳動脈における複雑な血流とそれに対する血管壁のリモデリングを考慮した計算力学シミュレーションにより, 動脈瘤の形成過程を再現した. これにより, 嚢状の動脈瘤の形成には, 受動的な変形を引き起こす血管壁の材料特性の変化だけでなく, 能動的な血管壁の拡張や成長が必要であることを示した. また, これらの応答を引き起こす血管構成細胞の力学特性を調べるために様々な細胞力学実験を行い, 細胞骨格が重要な役割を果たしていることを明らかにした.

Research Products

• [Journal Article] A rule-based computational study on the early progression of intracranial aneurysms using fluid-structure interaction : Comparison between straight model and curved model (2008)
  • Author(s): Feng Y, Wada S, Ishikawa T, Tsubota K, Yamaguchi T
  • Journal Title: Journal of Biomechanical Science and Engineering 3(2) Pages: 124-137
  • Peer Reviewed
• [Journal Article] Morphological study of fibroblasts treated with cytochalasin D and colchicine using a conforcal laser scanning microscopy (2008)
  • Author(s): Ujihara Y, Miyazaki H, Wada S
  • Journal Title: Journal of Physiological Sciences 58 Pages: 499-506
  • Peer Reviewed
• [Journal Article] Design of a DICOM image-based program for estimating patient exposure dose in computed tomography (2007)
  • Author(s): Yamamoto S, Horiuchi T, Sekiguch J, Wada S, Komizu M, Yamaguchi T
  • Journal Title: Technology and Health Care 15 Pages: 147-156
  • Peer Reviewed
• [Journal Article] Quantitative evaluation of intra-aortic flow disturbance by the fluid momentum index -effect of the left ventricular systolic function on the hemodynamics in the aorta- (2007)
  • Author(s): Nakamura M, Wada S, Yamaguchi T
  • Journal Title: Technology and Health Care 15 Pages: 111-120
  • Peer Reviewed
• [Journal Article] Measurement of blood flow in the left ventricle and aorta using clinical 2D cine phase-contrast magnetic resonance imaging (2007)
  • Author(s): Nakamura M, Wada S, Yokosawa S, Isoda H, Takeda H, Yamaguchi T
  • Journal Title: Journal of Biomechanical Science and Engineering 2 Pages: 46-57
  • Peer Reviewed
• [Journal Article] A rule-based simulation of the early development of intracranial aneurysms considering solid wall mechanics and fluid dynamics (2006)
  • Author(s): Wada S, Feng Y, Nakamura M, Yamaguchi T
  • Journal Title: dynamics, Proc. of the 7th World Congress on Computational Mechanic Pages: 16-22
• [Journal Article] Computational analysis of blood flow in an integrated model of the left ventricle and the aorta (2006)
  • Author(s): Nakamura M, Wada S, Yamaguchi T.
  • Journal Title: Journal of Biomechanical Engineering 128 Pages: 837-843
  • Peer Reviewed
• [Journal Article] Particle method for computer simulation of red blood cell motion in blood flow (2006)
  • Author(s): Tsubota K, Wada S, Yamaguchi T
  • Journal Title: Computer Methods and Programs in Biomedicine 83 Pages: 139-146
  • Peer Reviewed
• [Journal Article] The role of blood flow in the localization of vascular diseases : Speculation-based computer simulation (2005)
  • Author(s): Wada S, Feng Y, Yamaguch T, Karino T
  • Journal Title: Proceedings of the 3rd European Medical & Biological Engineering Conference (in CD-ROM) Pages: 5
• [Journal Article] A model-based numerical analysis in the early development of intracranial aneurysms (2005)
  • Author(s): Feng Y, Wada S, Tsubota K, Yamaguch T
  • Journal Title: Proceedings of the 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Pages: 607-610
• [Journal Article] Computational study on the geometric influence of a lateral wall aneurysm on the hemodynamics (2005)
  • Author(s): Sato K, Wada S, Tsubota K, Yamaguchi T
  • Journal Title: Proceedings of 2nd International Conference on Computational Bioengineering Pages: 535-544
• [Journal Article] Numerical model on the development of intracranial aneurysms considering fluid mechanics dependent solid wall mechanical property alternations (2005)
  • Author(s): Feng Y, Wada S, Tsubota K, Yamaguchi T
  • Journal Title: Proceedings of the ASME 2005 Summer Bioengineering Conference (in CD-ROM) Pages: 2
• [Journal Article] Isoda H, Phase contrast MRI measurements and CFD analysis of hemodynamics in the aorta (2005)
  • Author(s): Yokosawa S, Wada S, Nakamura M, Tsubota K, Yamaguchi T
  • Journal Title: Proceedings of the ASME 2005 Summer Bioengineering Conference (in CD-ROM) Pages: 2
• [Journal Article] Computational flow dynamics in abdominal aortic aneurysm using multislice computed tomography (2005)
  • Author(s): Yamamoto S, Maruyama S, Nakahara Y, Yoneyama S, Tanifuji S, Wada S, Hamada S, Komizu M, Johkoh T, Doi M, Yamaguchi T
  • Journal Title: Japanese Journal of Radiological Technology 62 Pages: 115-121
  • Peer Reviewed
• [Journal Article] Quantitative measurements on the human ascending aortic flow with cine phase-contrast magnetic resonance imaging (2005)
  • Author(s): Yokozawa S, Nakamura M, Wada S, Isoda H, Takeda H, Yamaguchi T
  • Journal Title: JSME International Journal 48 Pages: 459-467
  • Peer Reviewed
• [Journal Article] The application of computer simulation in the genesis and development of intracranial aneurysms (2005)
  • Author(s): Feng Y, Wada S, Tsubota K, Yamaguchi T
  • Journal Title: Technology & Health Care 13 Pages: 281-291
  • Peer Reviewed
• [Journal Article] Mass transport and fluid flow in stenotic arteries : Axisymmetric and asymmetric models (2005)
  • Author(s): Kaazempur-Mofrad MR, Wada S, Myers JG, Ethie CR
  • Journal Title: International Journal of Heat and Mass Transfer 48 Pages: 4510-4517
  • Peer Reviewed
• [Presentation] Spring network modeling for multiscale mechanics from cells to organs (2009)
  • Author(s): Wada S
  • Organizer: 4th Asian Pacific Conference on Biomechancs(Invited)
  • Place of Presentation: Christchurch
  • Year and Date: 2009-04-17
• [Presentation] 形状変化に伴う血行力学因子の変化を考慮した動脈瘤の成長シミュレーション (2009)
  • Author(s): 辻川寛, 中村匡徳, 越山顕一朗, 宮崎浩, 和田成生
  • Organizer: 日本機械学会関西学生会卒業研究発表講演会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-15
• [Presentation] Multiple red blood cell behavior in human circulation - Multi-scale modeling and simulation of blood flow- (2008)
  • Author(s): Wada S
  • Organizer: International Seminar on Heat Transfer and Fluid Flow(Invited)
  • Place of Presentation: Osaka
  • Year and Date: 2008-09-22
• [Presentation] Multiscale analysis of blood flow : modeling and simulation of multiple red blood cell flow (2008)
  • Author(s): Wada S
  • Organizer: 12th Asian Congress of Fluid Mechanics(Invited)
  • Place of Presentation: Daejeon
  • Year and Date: 2008-08-19
• [Presentation] 細胞の力学モデル (2008)
  • Author(s): 和田成生, 中村匡徳, 宮崎浩, 野口怜, 氏原嘉洋
  • Organizer: 第47回日本生体医工学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-05-08
• [Presentation] 養血管平滑筋細胞の局所的スティフネスに対する微小管の寄与 (2008)
  • Author(s): 石倉健一郎, 宮崎浩, 和田成生
  • Organizer: 日本機械学会第20回バイオエンジニアリング講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-01-25
• [Presentation] Computational analysis of development of a saccular aneurysm induced by local growth of a vessel wall (2008)
  • Author(s): Nakamura M, Yoshida K, Wada S
  • Organizer: 22nd SICE symposium on biological and physiological engineering
  • Place of Presentation: Harbin
  • Year and Date: 2008-01-13
• [Presentation] 医用計測と診断をつなぐ生体力学シミュレーション (2007)
  • Author(s): 和田成生
  • Organizer: 第5回医工学研究センターシンポジウム(招待)
  • Place of Presentation: 吹田
  • Year and Date: 2007-09-28
• [Presentation] 循環系の計算バイオメカニクス~赤血球の流動から心臓の流れまで~ (2007)
  • Author(s): 和田成生
  • Organizer: 日本機械学会年次大会(基調講演)
  • Place of Presentation: 吹田
  • Year and Date: 2007-09-11
• [Presentation] 血管壁成長に伴う血管形状変化 (2007)
  • Author(s): 吉田圭太, 中村匡徳, 宮崎浩, 和田成生
  • Organizer: 日本機械学会関西学生会卒業研究発表講演会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-15
• [Presentation] ルールベースト・シミュレーションによる拡張性動脈疾患の進行予測 (2006)
  • Author(s): 和田成生, Feng Y, 中村匡徳, 山口隆美
  • Organizer: 第19回計算力学講演会講演会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-11-04
• [Presentation] 血液の流れのシミュレーション~循環器病の予防・診断・治療に向けて~ (2006)
  • Author(s): 和田成生
  • Organizer: 第5回地球シミュレータセンター・シンポジウム(招待講演)
  • Place of Presentation: 東京
  • Year and Date: 2006-09-22
• [Presentation] A rule-based simulation of the early development of intracranial aneurysms considering solid wall mechanics and fluid dynamics (2006)
  • Author(s): Wada S, Feng Y, Nakamura M, Yamaguchi T
  • Organizer: 7th World Congress on Computational Mechanics
  • Place of Presentation: Los Angeles
  • Year and Date: 2006-07-20
• [Presentation] The role of blood flow in the localization of vascular diseases : Speculation-based computer simulation (2005)
  • Author(s): Wada S
  • Organizer: 3rd European Medical & Biological Engineering Conference
  • Place of Presentation: Prague
  • Year and Date: 2005-11-20
• [Book] Rule-based simulation of arterial wall thickening induced by low wall shear stress. In : Biomechanics at Micro- and Nanoscale Levels (2007)
  • Author(s): Wada S, Nakamura M, Karino T
  • Total Pages: 157-166
  • Publisher: World Scientific Co. Pte. Ltd., Singapore
• [Book] MRI measurements and CFD analysis of hemodynamics in the aorta and the left ventricle. In : Biomechanics at Micro- and Nanoscale Levels (2007)
  • Author(s): Nakamura M, Wada S, Yokosawa S, Yamaguchi T
  • Total Pages: 133-145
  • Publisher: World Scientific Co. Pte. Ltd., Singapore
• [Book] A computer simulation study on the early progression of intracranial aneurysms : A comparison between straight model and curved model, Future Medical Engineering Based on Bionanotechnology (Eds. M. Esashi et al.) (2007)
  • Author(s): Feng Y, Wada S, Tsubota K, Yamaguchi T
  • Total Pages: 909-918
  • Publisher: Imperial College Press, UK
• [Book] A new theory on the localization of vascular diseases, Biomechanics at Micro- and Nanoscale Levels, Vol.1(Ed. H. Wada) (2005)
  • Author(s): Karino T, Wada S, Naiki T
  • Total Pages: 100-112
  • Publisher: World Scientific Publishing Co., Singapore
• [Remarks]
  • URL: http://www-biomech.me.es.osaka-u.ac.jp/