2007 Fiscal Year Final Research Report Summary
Study on the glucose metabolism in skeletal muscle caused by peripheral sympathetic nerve stimulation
| Project/Area Number |
17300139
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Yamagata University |
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Principal Investigator |
NAKAMURA Takao Yamagata University, Grad. Sch. of Med. Sci, Professor (00142654)
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Yasutomo Yamagata University, Grad. Sch. of Med. Sci, Assoc. Prof (80237883)
KUSUNOKI Masataka Aichi Medical University, Medical Clinic, Lect (80214956)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Peripheral muscle / The sympathetic nervous system / Electrical stimulation / Peripheral muscle / Insulin / glycogen / triglyceride |
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| Research Abstract |
Types 1 and 2 diabetic model rats were made by administration of streptozotocin and by high fat feeding, respectively.
Peripheral sympathetic fibers in the sciatic nerve were electrically stimulated using microneurographic technique to enhance the local sympathetic activity. A transient reduction of blood glucose, which implies an enhancement of glucose uptake in peripheral tissues, was observed without increase in plasma insulin in normal and diabetic model rats. In addition, such reduction was also observed in plasma triglyceride. Response of sympathetic nerve system to the glucose load was deteriorated in the diabetic model rats. After each experiment, muscle tissues were resected to measure glycogen and triglyceride contents. Glycogen contents in stimulation side were somewhat lower than contralateral side. Glucose transporters 1 and 4 and their messenger RNA levels did not show statistically significant change. Experimental protocol might be subject to change to clarify the effect.
In addition to the original objectives, effects of the stimulation on lipid metabolism was suggested as well from the results shown above, Therefore, fatty acid distribution of fat tissues and so on was tried to measure. The results showed location dependency of fatty acids and different distribution between normal and diabetic model rats.
These results may show the possibility of artificial control of peripheral glucose uptake via non-insulin mediated path including the sympathetic nervous system.
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Research Products
(48 results)
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[Journal Article] Relationship between serum concentrations of saturated fatty acids and unsaturated fatty acids and the homeostasis model insulin resistance index in Japanese patients with type 2 diabetes mellitus.2007
Author(s)
Kusunoki, M, Tsutsumi, K, Nakayama, M, Kurokawa, T, Nakamuara, T, Ogawa, H, Fukuzawa, Y, Morishita, M, Koide, T, Miyata, T
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Journal Title
J.Medical Investigation 54(3,4)
Pages: 243-247
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Relationship between serum concentrations o fsaturated fatty acids and unsaturated fatty acids and the homeostasis model insulin resistance index in Japanese patients with type 2 diabetes mellitus2007
Author(s)
Kusunoks M, Tsutsumi K, Nakayama M, Kurokawa T, Nakamura T, Ogawa H, Fukuzawa Y, Morishita M, Koide T, Miyata T
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Journal Title
J. Medical Investigation 54(3, 4)
Pages: 243-247
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] NO-1886(ibrolipim),a lipoprotein lipase activator,increases the expression of uncoupling protein 3 in skeletal muscle and suppresses fat accumulation in high-fat diet-induced obesity in rats.2005
Author(s)
Kusunoki, M, Tsutsumi, K, Iwata, K, Yin, W, Nakamura, T, Ogawa, H, Nomura, T, Mizutani, K, Futenma, A, Utsumi, K, Miyata, T
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Journal Title
Metabolism 54
Pages: 1587-1592
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] NO-1886(ibrolipim), a lipoprotein lipase activator, increases the expression of uncoupllng protein 3 in skeletal muscle and suppresses fat accumulation in high-fat diet-induced obesity in rats2005
Author(s)
Kusunoki M, Tsutsumi K, Iwata K, Yin W, Nakamura T, Ogawa H, Nomura T, Mizutani K, Futenma A, Utsumi K, Miyata T
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Journal Title
Metabolism 54
Pages: 1587-1592
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Comparison of mRNA expression of transcriptional factors and intercalated disc constituent proteins between in vivo and cultured cardiomyocytes.2007
Author(s)
Nakamura, T, Feng, Z, Honda, T, Nomura, Y, Kitajima, T, Umezu, M
Organizer
45^<th> Annual Meeting Jpn. Soc. Artif. Organs and 2^<nd> Meeting Internat.Fed.Artif.Organs
Place of Presentation
Osaka
Year and Date
20071000
Description
「研究成果報告書概要(和文)」より
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