Contamination and risk evaluation for synthetic musk fragrances in the environment

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 17310038
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Kumamoto University
• Principal Investigator: SANEMASA Isao Kumamoto University, Graduate School of Science and Technology, Professor (60040119)
• Co-Investigator(Kenkyū-buntansha): NAKATA Haruhiko Kumamoto University, Graduate School of Science and Technology, Associate Professor (60311875) ; SAKAI Haruya Yokohama City University, School of Medicine, Assistant Professor (20303555)
• Project Period (FY): 2005 – 2007
• Keywords: Synthetic musk fragrance / HHCB / Marine environment / Bioconcentration / Temporal trend / Contamination in human / Endocrine disrupting effects / Kashin-Ho

Research Abstract

Bioaccumulation of synthetic musks in a marine food chain was investigated by analyzing marine organisms at various trophic levels, including lugworm, clam, crustacean, fish, marine mammal, and bird samples collected from tidal flat and shallow water areas of the Ariake Sea, Japan. Two of the polycyclic musks, HHCB and AHTN, were the dominant compounds found in most of the samples analyzed, whereas nitro musks were not detected in any of the organisms, suggesting greater usage of polycyclic musks relative to the nitro musks in Japan. The highest concentrations of HHCB were detected in clams (258 ng/g to 2,730 ng/g lipid wt.), whereas HHCB concentrations in mallard and black-headed gull were low, and comparable with concentrations in fish and crab. These results are in contrast to the bioaccumulation pattern of polychlorinated biphenyls ; for which a positive correlation between the concentration and the trophic status of organisms was found. Such a difference in the bioaccumulation is probably due to the metabolism and elimination of HHCB in higher trophic organisms. Temporal trend in concentrations of synthetic musks were examined by analyzing tissues of marine mammals from Japanese coastal waters collected during 1977-2005. HHCB concentrations in marine mammals have shown significant increase since the early 1990s, suggesting a continuous input of this compound into the marine environment. Comparison of the time trend for HHCB with those for PCBs and PBDEs suggested that the rates of increase in HHCB concentrations were higher than the other classes of pollutants. To examine the geographical distribution of HHCB, we have analyzed tissues of fish, marine mammals, and birds collected from several locations. Synthetic musks were not detected in a sperm whale (pelagic species) from Japanese coastal water and in eggs of south polar skua from Antarctica. While the number of samples analyzed is limited, these results imply a lack of long-range transportation potential of synthetic musks in the environment.

Research Products

• [Journal Article] 「スナメリWATCH」〜海洋汚染を監視するスナメリの役割とは (2008)
  • Author(s): 中田 晴彦
  • Journal Title: 勇魚(いさな)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 難分解性PPCPs(Pharmaceuticals and Personal Care Products)による海洋生態系の汚染解析 (2008)
  • Author(s): 中田 晴彦
  • Journal Title: Endocrine Disrupter News Letter
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 「 Finless porpoise Watch.」 Role of fmless porpoise for monitoring marine contamination〜(Japanese) (2008)
  • Author(s): Nakata, H.
  • Journal Title: Isana (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of persistent PPCPs(Pharmaceuticals and Personal Care Products) in the marine environment(Japanese) (2008)
  • Author(s): Nakata, H.
  • Journal Title: Endocrine Disrupter News Letter (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chapter 9 ; Accumulation of contaminants in marine mammals (2008)
  • Author(s): Nakata, H.
  • Journal Title: Cetacean Research(Murayama, T.(ed))(Japanese)(Tokai University Press) Pages: 423
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bioaccumulation,temporal trend,and geographical distribution of synthetic masks in the marine environment (2007)
  • Author(s): Nakata, H.
  • Journal Title: Environmental Science and Technology 41 Pages: 2216-2222
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 人工香料による海洋汚染の特徴生物濃縮・経年変動・汚染の現状と拡散について(総説) (2007)
  • Author(s): 中田 晴彦
  • Journal Title: 環境浄化技術 6 Pages: 7-12
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Bioaccumulation, temporal trend, and geographical distribution of synthetic musks in the marine environment (2007)
  • Author(s): Nakata, H., Sasaki, H., Takemura, A., Yoshioka, M., Tanabe, S., Kannan, K.
  • Journal Title: Environ. Sci. Technol. 41 Pages: 2216-2222
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Specific profile of Synthetic musks contamination in the marine environment ; Bioaccumulation, temporal trend and global distribution(Japanese) (2007)
  • Author(s): Nakata, H.
  • Journal Title: Environmental Solution Technology 6 Pages: 7-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Emerging contaminants : Synthetic musks in the marine environment (2007)
  • Author(s): Nakata, H., Sasaki, H., Ishimoto, Y., Takemura, A., Yoshioka, M., Tanabe, S., Kannan, K.
  • Journal Title: Chemical Pollution and Environmental Changes(Tanabe, S. Takeoka, H., Isobe, T., Nishibe, Y.(eds))(Universal Academy Press) Pages: 197-200
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of environmental endocrine disruptors on thyroid hormone receptor mediated transcriptional activity (2007)
  • Author(s): Sakai, H., Yamada-Okabe, T., Kahima, Y., Matusmoto, N.
  • Journal Title: Chemical Pollution and Environmental Changes(Tanabe, S. Takeoka, H., Isobe, T., Nishibe, Y.(eds))(Universal Academy Press) Pages: 255-257
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Uptake of benzene and alkylbenzenes by cation-and anion-exchange resins from aqueous solutions (2006)
  • Author(s): Sanemasa, I.
  • Journal Title: Analytical Science 22 Pages: 899-901
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Uptake of benzene and alkylbenzenes by cation- and anion-exchange resins from aqueous solutions (2006)
  • Author(s): Sanemasa, I
  • Journal Title: Anal. Sci. 22 Pages: 899-901
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Occurrence of synthetic musk fragrances in marine mammals and sharks from Japanese coastal waters (2005)
  • Author(s): Nakata, H.
  • Journal Title: Environmental Science and Technology 39 Pages: 3430-3434
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Uptake of cycloalkanes and bicyclic aromatic compounds by ion-exch ange resins from aqueous solutions (2005)
  • Author(s): Sanemasa, I.
  • Journal Title: Analytical Science 21 Pages: 1541-1544
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Modulation at a celluar level of the thyroid hormone receptor-mediated gene expression by 1,2,5,6,9,10-hexabromo-cyclododecane(HBCD),4,4' diiodobiphenyl(DIB),and nitrofen(NIP) (2005)
  • Author(s): Yamada-Okabe, T.
  • Journal Title: Toxicology Letters 155 Pages: 127-133
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Occurrence of synthetic musk fragrances in marine mammals and sharks from Japanese coastal waters (2005)
  • Author(s): Nakata, H.
  • Journal Title: Environ Sci. Technol. 39 Pages: 3430-3434
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Uptake of cycloalkanes and bicyclic aromatic compounds by ion-exchange resins from aqueous solutions (2005)
  • Author(s): Sanemasa, I., Izuno, M., Fujii, Y.
  • Journal Title: Anal. Sci. 21 Pages: 1541-1544
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Modulation at a celluar level of the thyroid hormone receptor-mediated gene expression by 1, 2, 5, 6, 9, 10-hexabromo- cyclododecane(HBCD), 4, 4' -diiodobiphenyl(DIB), and nitrofen(NIP) (2005)
  • Author(s): Yamada-Okabe, T., Sakai, H., Yamada-Okabe, H.
  • Journal Title: Toxicol. Lett. 155 Pages: 127-133
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthetic musks in air and seawater of the Ariake Sea (2008)
  • Author(s): Nakata, H., Sakanashi, Y, Takikawa, K.
  • Organizer: 17th Symposium on Environmental Chemistry
  • Place of Presentation: Kobe
  • Year and Date: 20080600
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Specific accumulation of synthetic musk fragrances in human breast milks and adipose tissues from Japan (2008)
  • Author(s): Moribe, M., Nakata, H., Ihn, H., Maruo, K., Kunisue, T., Tanabe, S., Inoue, K., Someya, T., Ryuda, N., Miyajima, T., Ichiba, M., oUeno, D.
  • Organizer: 17th Symposium on Environmental Chemistry
  • Place of Presentation: Kobe
  • Year and Date: 20080600
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mussel Watch-Pollution Monitoring of Synthetic Musks in Asian Coastal Waters (2007)
  • Author(s): Nakata, H.
  • Organizer: 16th Symposium on Environmental Chemistry
  • Place of Presentation: Kita-Kyushu,Japan
  • Year and Date: 20070600
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mussel Watch-Pollution Monitoring of Synthetic Musks in Asian Coastal Waters (2007)
  • Author(s): Nakata, H., Nakazawa, Y., Ishimoto, Y., Ramu, K., Kajiwara, N., Sudaryanto, A., Isobe, T., Takahashi, S., Subramanian, A., Kim, E., Zheng, G. J., Lam, P.K.S., Min, B., We, S., Viet, P.H., Ismail, A., Muchtar, M., Tana, T.S., Prudente, M., Tanabe, S.
  • Organizer: 16th Symposium on Environmental Chemistry
  • Place of Presentation: Kita-Kyushu
  • Year and Date: 20070600
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Emerging contaminants:Perfluorinated compounds and synthetic musks in the marine environment (2007)
  • Author(s): Nakata, H.
  • Organizer: Intemational Workshop on Perfluorinated Compounds in the Environment, Distribution and Fate
  • Place of Presentation: Busan,Korea
  • Year and Date: 20070100
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Emerging contaminants : Perfluorinated compounds and synthetic musks in the marine environment (2007)
  • Author(s): Nakata, H.
  • Organizer: International Workshop on Perfluorinated Compounds in the Environment, Distribution and Fate
  • Place of Presentation: Busan, Korea
  • Year and Date: 20070100
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Emerging contaminants:Synthetic musks in the marine environment (2006)
  • Author(s): Nakata, H.
  • Organizer: COE Intemational Symposium2006:Pioneering Studies of Young Scientists on Chemical Pollution and Environmental Changes
  • Place of Presentation: Matsuyama,Japan
  • Year and Date: 20061100
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effects of environmental endocrine disruptors on thyroid hormone receptor mediated transcriptional activity (2006)
  • Author(s): Sakai, H.
  • Organizer: COE International Symposium2006:Pioneering Studies of Young Scientists on Chemical Pollution and Environmental Changes
  • Place of Presentation: Matsuyama,Japan
  • Year and Date: 20061100
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Emerging contaminants : Synthetic musks in the marine environment (2006)
  • Author(s): Nakata, H., Sasaki, H., Ishimoto, Y., Takemura, A., Yoshioka, M., Tanabe, S., Kannan, K.
  • Organizer: COE International Symposium 2006 : Pioneering Studies of Young Scientists on Chemical Pollution and Environmental Changes
  • Place of Presentation: Japan
  • Year and Date: 20061100
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effects of environmental endocrine disruptors on thyroid hormone receptor mediated transcriptional activity (2006)
  • Author(s): Sakai, H., Yamada-Okabe, T., Kahima, Y., Matusmoto, N.
  • Organizer: COE International Symposium 2006 : Pioneering Studies of Young Scientists on Chemical Pollution and Environmental Changes
  • Place of Presentation: Japan
  • Year and Date: 20061100
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Bioaccumulation,temporal trend and geographical distribution of synthetic musk fragrances in the marine environment (2006)
  • Author(s): Nakata, H.
  • Organizer: Society of Environmental Toxicology and Chemistry(SETAC)North America27th Annual Meeting
  • Place of Presentation: Montreal,Canada
  • Year and Date: 20060800
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Bioaccumulation, temporal trend and geographical distribution of synthetic musk fragrances in the marine environment. Society of Environmental Toxicology and Chemistry(SETAC) North America (2006)
  • Author(s): Nakata, H., Kannan, K., Sasaki, H., Takemura, A., Nakabo, T., Yoshioka, M., Kajiwara, N., Tanabe, S.
  • Organizer: 27th Annual Meeting
  • Place of Presentation: Montreal, Canda
  • Year and Date: 20060800
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 合成香料による海洋汚染の特徴〜生物濃縮・経年変動・濃度分布について (2006)
  • Author(s): 中田 晴彦
  • Organizer: 第15回環境化学討論会
  • Place of Presentation: 仙台市
  • Year and Date: 20060600
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 合成香料におけるヒトへの汚染経路の検索〜香水・生活用品・ハウスダスト中の測定結果より (2006)
  • Author(s): 中田 晴彦
  • Organizer: 第15回環境化学討論会
  • Place of Presentation: 仙台市
  • Year and Date: 20060600
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] カキを指標にした日本沿岸域の合成香料汚染マップの作成 (2006)
  • Author(s): 石本 裕生
  • Organizer: 第15回環境化学討論会
  • Place of Presentation: 仙台市
  • Year and Date: 20060600
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthetic musk fragrances in marine environment : Bioaccumulation, temporal trend, and geographical distribution (2006)
  • Author(s): Nakata, H., Sasaki, H., Takemura, A., Tanabe, S., Kajiwara, N., Yoshioka, M., Kannan, K.
  • Organizer: 15th Symposium on Environmental Chemistry
  • Place of Presentation: Sendai
  • Year and Date: 20060600
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Concentrations of synthetic musks in perfumes, cosmetics, household material, foodstuffs, and house dusts : Estimation for possible intake pathways of synthetic musks in human (2006)
  • Author(s): Nakata, H., Fukahori, A.
  • Organizer: 15th Symposium on Environmental Chemistry
  • Place of Presentation: Sendai
  • Year and Date: 20060600
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Monitoring survey on the contamination of synthetic musk fragrances in Japanese coastal waters using oyster as a bioindicator (2006)
  • Author(s): Ishimoto, Y., Nakata, H.
  • Organizer: 15th Symposium on Environmental Chemistry
  • Place of Presentation: Sendai
  • Year and Date: 20060600
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthetic musk fragrancesin marine mammals and other aquatic organisms from Japanese coastal waters (2005)
  • Author(s): Nakata, H.
  • Organizer: 25th Intemational Symposium on Halogenated Environmental Organic Pollutants and POPs
  • Place of Presentation: Toronto,Canada
  • Year and Date: 20050800
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthetic musk fragrances in marine mammals and other aquatic organisms from Japanese coastal waters (2005)
  • Author(s): Nakata, H., Sasaki, H., Nakabo, T., Takemura, A.
  • Organizer: 25th International Symposium on Halogenated Environmental Organic Pollutants and POPs
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20050800
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 合成香料による海生哺乳類および魚類の汚染と生物濃縮について (2005)
  • Author(s): 中田 晴彦
  • Organizer: 第14回環境化学討論会
  • Place of Presentation: 大阪市
  • Year and Date: 20050600
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Contamination and biomagnification of synthetic musk fragrances in marine mammals and fish (2005)
  • Author(s): Nakata, H., Sasaki, H., Nakabo, T., Takemura, A.
  • Organizer: 14th Symposium on Environmental Chemistry
  • Place of Presentation: Osaka
  • Year and Date: 20050600
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 第9章海洋汚染と鯨類鯨類学 (2008)
  • Author(s): 中田 晴彦
  • Publisher: 東海大学出版会(印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Emerging contaminants:Synthetic musks the marine environment Chemical Pollution and Environmental Changes (2006)
  • Author(s): Nakata, H.
  • Total Pages: 450
  • Publisher: Universal Academy Press
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Effects of environmentalendocrine disruptors on thyroid hormone receptor mediated transcriptional activity. Chemical Pollution and Environmental Changes (2006)
  • Author(s): Sakai, H.
  • Total Pages: 450
  • Publisher: Universal Academy Press
  • Description: 「研究成果報告書概要(和文)」より
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://www.sci.kumamoto-u.ac.jp/~nakata/