2008 Fiscal Year Final Research Report
Risk evaluation and toxicity mechanism of air-borne particulate matter and its major chemical components
| Project/Area Number |
17310039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
YAGI Takashi Osaka Prefecture University, 産学官連携機構, 教授 (80182301)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOHATA Akira 大阪府立大学, 産学官連携機構, 教授 (80090439)
KAWANISHI Masanobu 大阪府立大学, 産学官連携機構, 助教 (70332963)
NAKAYAMA Aki 京都大学, 大学院・工学研究科, 助教 (10335200)
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| Project Period (FY) |
2005 – 2008
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| Keywords | 大気汚染 / 粒子状物質 / 環境変異原 / がん / リスク |
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| Research Abstract |
堺市で採取した大気浮遊粒子の変異原性および内分泌撹乱性(ダイオキシン受容体およびエストロゲン受容体リガンド活性)を確認した。その主たる成分であるベンゾ(a)ピレン、1, 8-ジニトロピレン、3, 6-ジニトロベンゾ(e)ピレン、3-ニトロベンズアントロン、4-アミノビフェニルの突然変異誘発機構を分子・細胞生物学的方法で調べ、それらに共通した細胞周期特異的なDNA 損傷応答、および損傷に特異的なDNA ポリメラーゼの関与と突然変異誘発性を明らかにした。
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[Journal Article] Genotoxicity of 3, 6-dinitrobenzo[e]pyrene, a novel mutagen in ambient air and surface soil, in mammalian cells in vitro and in vivo2009
Author(s)
Kawanishi, M., Watanabe, T., Hagio, S., Ogo, S., Shimohara, C., Jouchi, R., Takayama, S., Hasei, T., Hirayama, T., Oda, Y. and Yagi, T.
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Journal Title
Peer Reviewed
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[Journal Article] DNA adduct formation in human hepatoma cells treated with 3-nitrobenzanthrone : analysis by the ^<32>P-postlabeling method2007
Author(s)
Kanno, T., Kawanishi, M., Takamura-Enya, T., Arlt, V. M., Phillips, D. H.,Yagi. T.
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Journal Title
Mutat. Res 634
Pages: 184-191
Peer Reviewed
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[Journal Article] Identification of three major DNA adductsformed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine2006
Author(s)
Arlt, V. M., Schmeiser, H. H., Osborne, M. R., Kawanishi, M., Kanno, T., Yagi, T.Phillips D. H. and Takamura-Enya, T.
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Journal Title
Int. J. Cancer 118(9)
Pages: 2139-2146
Peer Reviewed
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[Journal Article] A physiologically based pharmacokinetic model for endosulfan in the male Sprague-Dawley rats2006
Author(s)
Chan, M.P., Morisawa, S, Nakayama, A., Kawamoto, Y., Sugimoto, M., Yoneda, M.
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Journal Title
Environ. Toxicol 21(5)
Pages: 464-478
Peer Reviewed
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