2006 Fiscal Year Final Research Report Summary
Study of oxygen transport in tissue using reflection type diffuse optical tomography
| Project/Area Number |
17360095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thermal engineering
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
YAMADA Yukio The University of Electro-Communications, Dept. of Mechanical Engineering and Intelligent Systems, Professor (10334583)
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| Co-Investigator(Kenkyū-buntansha) |
KAKUTA Naoto Kyushu University, Faculty of Engineering, Associate Professor (70345437)
TANIKAWA Yukari National Institute of Advanced Industrial Science and Technology, Institute for Human Science and Biomedical Engineering, Senior Researcher (20344202)
SAKARANI Kaoro Nihon University, School of Medicine, Professor (90244350)
HOSHI Yoko The University of Electro-Communications, Research Director (50332383)
OKAWA Shinpei The University of Electro-Communications, Dept. of Mech. Intel. Sys., Assistant Professor (20432049)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Diffuse Optical Tomography / near infrared light / time-resolved measurement / inverse problem / higher brain function / optical mapping |
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| Research Abstract |
Study of transport phenomena in human body is essential to understand the complex physiological mechanisms in living organisms. In recent years, noninvasive monitoring of hemodynamics using near infrared (NIR) light has been gaining the attention. NIR light diffusively propagates through biological tissues, and its absorption spectrum varies with blood oxygenation. These allow us Diffuse Optical Tomography (DOT) which can illustrate the spatial distribution of the hemoglobin concentrations within the tissues. This study intended to unveil the hemodynamics in the brain and muscles with DOT.
Simple DOT systems using continuous-light can generate tomographic images when transmitted light through the object is detectable. However, it is difficult to obtain images only from the data of the reflected light when the transmitted light is undetectable due to the large size of the object. Pico-second time resolved measurement makes it possible to obtain tomographic images from reflected light. We attempted to monitor the hemodynamics in an adult brain with reflection-type DOT using a pico-second time-resolved measurement system, and discussed the related issues as well.
The major achievements of this study are as the following :
(i) It is proven by the numerical simulation and in vivo experiments that reflection-type DOT images can be obtained by a pico-second time resolved measurement system in the case of large objects such as an adult head through which the transmitted light is undetectable. (ii) It is found that the precise measurement of the positions of the source-detector optical fibers attached on the skin of the subject is essential for high-quality imaging. (iii) The DOT images of the oxygenation and blood volume in frontal lobe during calculation tasks were obtained. (iv) Optical mapping using the reflected light data is found to be affected by the structure of the head, especially by the cerebrospinal fluid and the skull layers.
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[Presentation] In vivo measurement of premature neonate head using diffuse optical tomography2007
Author(s)
M. Ueno, R. Fukuzawa, S. Okawa, Y. Yamada, T. Kusaka, T. Nishida, K. Isobe, Y. Tanikawa, F. Gao, C. Sato, Y. Hoshi
Organizer
APBP 2007, 3rd Asian and Pacific Rim Symposium on Biophotonics
Place of Presentation
Cairns, Australia
Year and Date
20070709-11
Description
「研究成果報告書概要(欧文)」より
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