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2007 Fiscal Year Final Research Report Summary

Molecular mechanisms involved in the repair and regeneration of injured gastrointestinal mucosa tissue

Research Project

Project/Area Number 17390116
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionUniversity of Miyazaki

Principal Investigator

KATAOKA Hiroaki  University of Miyazaki, Faculty of Medicine, Professor (10214321)

Co-Investigator(Kenkyū-buntansha) ITOH Hiroshi  University of Fukui, Faculty of Medicine, Professor (80253847)
AKIYAMA Yutaka  University of Miyazaki, Faculty of Medicine, Assistant Professor (00347056)
Project Period (FY) 2005 – 2007
Keywordsmucosal regeneration / digestive tracts / HGF activation system / HGF activator / HAI-1 / H2RSP / membrane-bound proteinases / IGFBP-2
Research Abstract

In this project, we have analyzed the roles of HGF-activating enzymes, their inhibitor HAI-1, and novel intestinal peptide H2RSP in the regenerative process of epithelial tissue, particularly of the digestive tracts.
HGF is activated in response to tissue injury. To date, HGF activator (HGFA), matriptase, hepsin have been reported to be responsible for this activation process. By using HGFA knockout (KO) mice, we have found that HGFA has important role in the process of epithelial restitution of injured intestinal mucosal tissue. Moreover, we also found that HGFA activity was important in the prevention of pulmonary fibrosis and in the process of B-cell maturation. Furthermore, we have identified KLK4 and KLK5 as novel and specific activating proteinases of pro-HGFA.
The activities of HGF-activating enzymes are regulated by a membrane-bound serine proteinase inhibitor, namely HAI-1 (HGFA inhibitor type 1). HAI-1 is abundantly expressed in the epithelial tissue such as gastrointestinal ep … More ithelium. We have developed HAI-1 KO mice. The KO mice were embryonic lethal due to impaired placental development. Then we intended to rescue the placental function in HAI-1 KO mice by chimera approach. After placental rescue, HAI-1-/- neonate was successfully delivered. However, they were lethal at 14 days after birth with significant skin phenotypes. Therefore HAI-1 has a critical role in the normal development and homeostasis of the skin. In order to further study the functions of HAI-1 in the gastrointestinal tracts, we decided to develop a conditional KO system for HAI-1 gene. Currently, the generation of floxed HAI-1 mice is underway.
The novel peptide, H2RSP, was abundantly expressed in the intestinal epithelium. H2RSP is a nuclear proteins and its nuclear translocation occurs in response to cellular differentiation. Interestingly, the nuclear localization of H2RSP was impaired in actively migrating epithelial cells during restitution. It was also downregulated in colon carcinoma cells. Rather surprisingly, invading cancer cells at the invasion front of colon cancer paradoxically expressed H2RSP and its subcellular localization was intracytoplasmic. Moreover, colon cancers with increased numbers of cytoplasmic H2RSP-positive cells at the invasion front showed enhanced lymph node metastases.
We also studied IGFBP2, an important regulator of IGF signaling, and found that IGFBP-2 is somehow involved in the invasion of glioblastoma cells. Then we have identified CD24 as an important downstream molecule of IGFBP-2-induced cellular invasiveness. Less

  • Research Products

    (53 results)

All 2008 2007 2006 2005 Other

All Journal Article (34 results) (of which Peer Reviewed: 17 results) Presentation (19 results)

  • [Journal Article] Activation of hepatocyte growth factor activator zymogen(pro-HGFA)by human kallikrein 1-related peptidases.FEBS J.,275:1003-1017,20082008

    • Author(s)
      Mukai S, Fukushima T, Naka D, Tanaka H, Osada Y, Kataoka H
    • Journal Title

      FEBS Journal 275

      Pages: 1003-1017

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Activation of MET receptor tyrosine kinase in ulcer surface epithelial cells undergoing restitution2008

    • Author(s)
      Nagai H, Takahashi N, Miyazawa K, Kawaguchi M, Chijiiwa K, Kataoka H
    • Journal Title

      Pathology International (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Activation of hepatocyte growth factor activator zymogen(pro-HGFA) by human kallikrein 1-related peptidases2008

    • Author(s)
      Mukai, S., Fukushima, T., Naka, D., Tanaka, H., Osada, Y., Kataoka, H
    • Journal Title

      FEBS Journal 275

      Pages: 1003-1017

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide(H2RSP)at the invasive front of colon cancers2007

    • Author(s)
      Uchiyama S, Itoh H, Naganuma S, Nagaike K, Fukushima T, Tanaka H, Hamasuna R, Chijiiwa K, Kataoka H.
    • Journal Title

      Gut 56

      Pages: 215-226

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The cytotrophoblasts layer of human chorionic Villi becomes thinner but maintains its structural integrity during gestation2007

    • Author(s)
      Mori M, Ishikawa G, Luo S-S, Mishima T, Goto T, Robinson JM, Matsubara S, Takeshita T, Kataoka H, Takizawa T.
    • Journal Title

      Biology of Reproduction 76

      Pages: 164-172

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type2(HAI-2)expression in renal cell carcinoma2007

    • Author(s)
      Betsunoh H, Mukai S, Akiyama Y, Fukushima T, Minamiguchi N, Hasui Y, Osada Y, Kataoka H.
    • Journal Title

      Cancer Science 98

      Pages: 491-498

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Silencing of insulin-like growth factor binding protein-2(IGFBP-2)in human glioblastoma cells reduces both invasiveness and expression of progression-associated gene CD24.J.Biol.Chem.,282:18634-18644(2007)2007

    • Author(s)
      Fukushima T, Tezuka T, Shimomura T, Nakano S, Kataoka H.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 18634-18644

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Role of Kunitz domains in anti-invasive effect of hepatocvte growth factor activator inhibitor type 1 in human glioblastoma cells2007

    • Author(s)
      Miyata S, Fukushima T, Kohama K, Tanaka H, Takeshima H, Kataoka H.
    • Journal Title

      Human Cell 20

      Pages: 100-106

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide(H2RSP) at the invasive front of colon cancers2007

    • Author(s)
      Uchiyama, S., Itoh, H., Naganuma, S., Nagaike, K., Fukushima, T., Tanaka, H., Haraasuna, R., Chijiiwa, K., Kataoka, H
    • Journal Title

      Gut 56(2)

      Pages: 215-226

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The cytotrophoblasts layer of human chorionic villi becomes thinner but maintains its structural integrity during gestation2007

    • Author(s)
      Mori, M., Ishikawa, G., Luo, S.-S., Mishima, T., Goto, T., Robinson, JM., Matsubara, S., Takeshita, T., Kataoka, H., Takizawa, T
    • Journal Title

      Biology of Reproduction 76

      Pages: 164-172

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2(HAI-2) expression in renal cell carcinoma2007

    • Author(s)
      Betsunoh, H., Mukai, S., Akiyama, Y., Fukushima, T., Minamiguchi, N., Hasui, Y., Osada, Y., Kataoka, H
    • Journal Title

      Cancer Science 98

      Pages: 491-498

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Silencing of insulin-like growth factor binding protein-2(IGFBP-2) in human glioblastoma cells reduces both invasiveness and expression of progressionassociated gene CD242007

    • Author(s)
      Fukushima, T., Tezuka, T., Shimomura, T., Nakano, S., Kataoka, H
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 18634-18644

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of Kunitz domains in anti-invasive effect of hepatocyte growth factor activator inhibitor type 1 in human glioblastoma cells2007

    • Author(s)
      Miyata, S., Fukushima, T., Kohama, K., Tanaka, H., Takeshima, H., Kataoka, H
    • Journal Title

      Human Cell 20

      Pages: 100-106

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo2006

    • Author(s)
      Uchinokura S, Niyata S, Fukushima T, Itoh H, Nakano S, Wakisaka S, Kataoka H.
    • Journal Title

      International Journal of Cancer 118

      Pages: 583-592

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Nuclear translocation of H2RSP is impaired in regenerating intesrinal epithelial cells of murine colitis model2006

    • Author(s)
      Naganuma S, Itoh H, Uchiyama S, Nagaike K, Tanaka H, Akivama Y, Chigiiwa K, Kataoka H.
    • Journal Title

      Virchows Archiv 448

      Pages: 354-360

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis2006

    • Author(s)
      Marchand-Adam S, Fabre A, Andre Mailleux A, Marchal J, Quesnel C, Kataoka H, et. al.
    • Journal Title

      American Journal of Respriration and Critical Care Medicine 174

      Pages: 58-66

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Expression of hepatocyte growth factor activator inhibitor type 1 in endothelial cells2006

    • Author(s)
      Akivama Y, Nagai M, Komaki W, Marutsuka K, Asada Y, Kataoka H.
    • Journal Title

      Human Cell 19

      Pages: 91-97

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats feda cholin-deficient L-amino acid-deficient diet2006

    • Author(s)
      Nakanishi C, Moriuchi A, Ido A, Numata M, Kim ID, Kusumoto K, Hasuike S, Abe H, Nagata K, Akiyama Y, Uto H, Kataoka H, Tsubouchi H.
    • Journal Title

      Oncology Reports 16

      Pages: 25-31

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Identification of antibodies against HAI-1 and integrin α6β4 as immunohistochemical markers of human villous cytotrophoblast2006

    • Author(s)
      Hallikas OT, Aaltonen JA, von Koskull, H, Lindberg L-A, Valmu L, Kalkkinen N, Washlstro T, Kataoka H, et. al.
    • Journal Title

      Journal of Histochemistry and Cytochemistry 54

      Pages: 745-752

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Augmented expression of hepatocyte growth factor activator inhibitor type 1 (HAI-1)in in trahepatic small bile ducts in primary biliary cirrhosis2006

    • Author(s)
      Sasaki M, Ikeda H, Kataoka H, Nakanuma Y.
    • Journal Title

      Virchows Archiv 449

      Pages: 462-471

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Role of hepatocyte growth factor activator(HGF activator) in invasive growth of human glioblastoma cells in vivo2006

    • Author(s)
      Uchinokura, S., Miyata, S., Fukushima, T., Itoh, H., Nakano, S., Wakisaka, S., Kataoka, H
    • Journal Title

      International Journal of Cancer 118

      Pages: 583-92

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Nuclear translocation of H2RSP is impaired in regenerating intestinal epithelial cells of murine colitis model2006

    • Author(s)
      Naganuma, S., Itoh, H., Uchiyama, S., Nagaike, K., Tanaka, H., Akiyama, Y., Chijiiwa, K., Kataoka, H
    • Journal Title

      Virchows Archiv 448

      Pages: 354-360

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats fed a cholin-deficient L-araino acid-deficient diet2006

    • Author(s)
      Nakanishi, C., Moriuchi, A., Ido, A., Numata, M., Kim, ID., Kusumoto, K., Hasuike, S., Abe, H., Nagata, K., Akiyarama, Y., Uto, H., Kataoka, H., Tsubouchi, H
    • Journal Title

      Oncology Reports 16

      Pages: 25-31

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis2006

    • Author(s)
      Marchand-Adam, S., Fabre, A., Andre, A., Mailleux, J., Marchal, C., Quesnel, H., Kataoka, M., Aubier, M., Dehoux, P., Soler, Crestani, B
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine 174

      Pages: 58-66

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of hepatocyte growth factor activator inhibitor type 1 in endothelial cells2006

    • Author(s)
      Akiyama, Y., Nagai, M., Komaki, W., Marutsuka, K., Asada, Y., Kataoka, H
    • Journal Title

      Human Cell 19

      Pages: 91-97

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Identification of antibodies against HAI-1 and integrin a6B4 as immunohistochemical markers of human villous cytotrophoblast2006

    • Author(s)
      Hallikas, OT, Aaltonen, JA, von Koskull, H., Lindberg, L.-A., Valmu, L., Kalkkinen, N., Washlstro, T., Kataoka, H., Andersson, L., Lindholm, D., Schroer, J
    • Journal Title

      Journal of Histochemistry and Cytochemistry 54

      Pages: 745-752

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Augmented expression of hepatocyte growth factor activator inhibitor type 1(HAI-1) in intrahepatic small bile ducts in primary biliary cirrhosis2006

    • Author(s)
      Sasaki, M., Ikeda, H., Kataoka, H., Nakanuma, Y
    • Journal Title

      Virchows Archiv 449

      Pages: 462-471

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hepatocvte growth factor activator inhibitor type1(HAI-1)is required for branching morphogenesis in the chorioallantoic placenta2005

    • Author(s)
      Tanaka H, Itoh H, Ratoka H, et. al.
    • Journal Title

      Molecular and Cellular Biology 25

      Pages: 5687-5698

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Follicular dendritic cells catalyze hepatocyte growth factor (HGF)activation in the germinal center microenvironment by secreting the serine protease HGF activator2005

    • Author(s)
      Tjin EPM, Bebde RJ, Derksen PWB, Van Huijstee A-P, Rataoka H, Spaargaren M, Pals ST.
    • Journal Title

      Juournal of Immunology 175

      Pages: 2807-2813

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Diverse roles of hepatocyte growth factor activator inhibitor type 1(HAI-1) in the growth of glioblastoma cells in vivo2005

    • Author(s)
      Miyata S, Uchinokura S, Fukushima T, Hamasuna R, Itoh H, Akiyama Y, Nakano S, Wakisaka S, Kataoka H.
    • Journal Title

      Cancer Letters 227

      Pages: 83-93

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1(HAI-1) is required for branching morphogenesis in the chorioallantoic placenta2005

    • Author(s)
      Tanaka, H., Nagaike, K., Takeda, N., Itoh, H., Kohama, K., Fukushima, T., Miyata, S., Uchinokura, S., Shimomura, T., Miyazawa, K., Kitamura, N., Yamada, G., Kataoka, H
    • Journal Title

      Molecular and Cellular Biology 25

      Pages: 5687-5698

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Diverse roles of hepatocyte growth factor activator inhibitor type 1(HAI-1) in the growth of glioblastoma cells2005

    • Author(s)
      Miyata, S., Uchinokura, S., Fukushima, T., Hamasuna, R., Itoh, H., Akiyama, Y., Nakano, S., Wakisaka, S., Kataoka, H
    • Journal Title

      Cancer Letters 227

      Pages: 83-93

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Follicular dendritic cells catalyze hepatocyte growth factor(HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator2005

    • Author(s)
      Tjin, EPM, Bebde, RJ, Derksen, PWB, Van Huijstee, A-P, Kataoka, H., Spaargaren, M., Pals, ST
    • Journal Title

      Journal of Immunology 175

      Pages: 2807-2813

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Activation of MET receptor tyrosine kinase in ulcer surface epithelial cells undergoing restitution

    • Author(s)
      Nagai, M., Takahashi, N., Miyazawa, K., Kawaguchi, M., Chijiiwa, K., Kataoka, H
    • Journal Title

      Pathology International (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Silencing of CD24 affects some progression-associated genes in human glioblastoma cells2008

    • Author(s)
      Fukushima, T., Kawaguchi, M., Takahashi, N., Tanaka, H., Itoh, H., Kataoka, H
    • Organizer
      99th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      SanDiego, CA, USA
    • Year and Date
      20080400
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Hepatocyte growth factor activator is a serum activator of single-chain precursor of macrophage- stimulating protein2008

    • Author(s)
      Kawaguchi, M., Nagai, M., Fukushima, T., Orikawa, H., Kataoka, H
    • Organizer
      99th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      SanDiego, CA, USA
    • Year and Date
      20080400
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Establishment of a new gastrointestinal stromal tumor cell line, GLMT-1, from a metastatic liver tumor treated by imatinib therapy2008

    • Author(s)
      Takahashi, N., Fukushima, T., Nagaike, K., Chijiiwa, K., Iwamura, T., Kataoka, H
    • Organizer
      99th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      SanDiego, CA, USA
    • Year and Date
      20080400
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Deletion of hepatocyte growth factor activator inhibitor type 1(HAI-1)proteinleads to ichthyosis in mice2007

    • Author(s)
      Kataoka H, Nagaike R, Kawaguchi M, Kohama K, Tanaka H, Fukushima T
    • Organizer
      98th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      米国カリフォルニア州ロサンゼルス
    • Year and Date
      20070400
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human tissue kallikrein 52007

    • Author(s)
      Mukai S, Takahashi N, Betsunoh H, Fukushima T, Tanaka H, Iwamura T, Kataoka H
    • Organizer
      98th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      米国カリフォルニア州ロサンゼルス
    • Year and Date
      20070400
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Deletion of hepatocyte growth factor activator inhibitor type 1(HAI-1) protein leads to ichthyosis in mice2007

    • Author(s)
      Kataoka, H., Nagaike, K., Kawaguchi, M., Kohama, K., Tanaka, H., Fukushima, T
    • Organizer
      98th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      LosAngeles, CA, USA
    • Year and Date
      20070400
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Activation of hepatocyte growth factor activator zymogen(pro-HGFA) by human tissue kallikrein 52007

    • Author(s)
      Mukai, S., Takahashi, N., Betsunoh, H., Fukushima, T., Tanaka, H., Iwamura, T., Kataoka, H
    • Organizer
      98th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      LosAngeles, CA, USA
    • Year and Date
      20070400
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Correlation of expression of hepatocyte growth factor related proteins with clinical outcome in human renal cell carcinoma2007

    • Author(s)
      Betsunoh H, Mukai S, Hasui Y, Osada Y, Kataoka H
    • Organizer
      7th Joint Meeting of AACR and JCA
    • Place of Presentation
      米国ハワイ州ワイコロア
    • Year and Date
      20070100
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Upregulation of hepatocyte growth factor activator inhibitor type 2(HAI-2)-related small peptide (H2RSP)at the invasion front of human coloncancer tissue2007

    • Author(s)
      Uchiyama S, Itoh H, Naganuma S, Nagaike R, Fukushima T, Tanaka H, Chijiiwa K, Kataoka H
    • Organizer
      7th Joint Meeting of AACR and JCA
    • Place of Presentation
      米国ハワイ州ワイコロア
    • Year and Date
      20070100
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Roles of CD24 in glioblastoma2007

    • Author(s)
      Fukushima T, Tezuka T, Shimomura T, Kataoka H
    • Organizer
      7th Joint Meetino of AACR and JCA
    • Place of Presentation
      米国ハワイ州ワイコロア
    • Year and Date
      20070100
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Correlation of expression of hepatocyte growth factor related proteins with clinical outcome in human renal cell carcinoma2007

    • Author(s)
      Betsunoh, H., Mukai, S., Hasui, Y., Osada, Y., Kataoka, H
    • Organizer
      7th Joint Meeting ofAACR and JC
    • Place of Presentation
      Waikoloa, HI, USA
    • Year and Date
      20070100
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Upregulation of hepatocyte growth factor activator inhibitor type 2(HAI-2)-related small peptide(H2RSP) at the invasion front of human colon cancer tissue2007

    • Author(s)
      Uchiyama, S., Itoh, H., Naganuma, S., Nagaike, K., Fukushima, T., Tanaka, H., Chijiiwa, K., Kataoka, H
    • Organizer
      7th Joint Meeting of AACR and JCA
    • Place of Presentation
      Waikoloa, HI, USA
    • Year and Date
      20070100
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Roles of CD24 in glioblastoma.2007

    • Author(s)
      Fukushima, T., Tezuka, T., Shimomura, T., Kataoka, H
    • Organizer
      7th Joint Meeting ofAACR and JCA
    • Place of Presentation
      Waikoloa, HI, USA
    • Year and Date
      20070100
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Functional analysis of insulin-like growth factor binding protein 2(IGFBP2) in human glioblastoma cells by RNA interference2006

    • Author(s)
      Fukushima T, Miyata S, Uchinokura S, Tezuka T, Shimomura T, Kataoka H
    • Organizer
      97th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      米国ワシントンDC
    • Year and Date
      20060400
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Functional analysis of insulin-like growth factor binding protein 2(IGFBP2) in human glioblastoma cells by RNA interference2006

    • Author(s)
      Fukushima, T., Miyata, S., Uchinokura, S., Tezuka, T., Shimomura, T., Kataoka, H
    • Organizer
      97th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      20060400
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Roles of integral membrane Kunitz-type serine proteinase inhibitor,HAI-1,in the invasive cell behavior2005

    • Author(s)
      Nagaike K, Tanaka H, Kohama K, Fukushima T, Naganuma S, Uchiyama S, Itoh H. Rataoka H
    • Organizer
      96th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      米国カリフォルニア州アナハイム
    • Year and Date
      20050400
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Expression of hepatocyte growth factor activator inhibitor type-2 related small peptide(H2RSP)in human gastrointestinal tissues including adenoma-carcinoma sequence2005

    • Author(s)
      Uchiyama S, Itoh H, Naganuma S, Nagaike K, Tanaka H, Chijiiwa K, Kataoka H
    • Organizer
      96th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      米国カリフォルニア州アナハイム
    • Year and Date
      20050400
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Roles of integral membrane Kunitz-type serine proteinase inhibitor, HAI-1, in the invasive cell behavior2005

    • Author(s)
      Nagaike, K., Tanaka, H., Kohama, K., Fukushima, T., Naganuma, S., Uchiyama, S., Itoh, H., Kataoka, H
    • Organizer
      96th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      Anaheim, CA, USA
    • Year and Date
      20050400
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Expression of hepatocyte growth factor activator inhibitor type-2 related small peptide(H2RSP) in human gastrointestinal tissues including adenoma-carcinoma sequence2005

    • Author(s)
      Uchiyama, S., Itoh, H., Naganuma, S., Nagaike, K., Tanaka, H., Chijiiwa, K., Kataoka, H
    • Organizer
      96th Annual Meeting of American Association of Cancer Research
    • Place of Presentation
      Anaheim, CA, USA
    • Year and Date
      20050400
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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