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2007 Fiscal Year Final Research Report Summary

Prevention for allergic diseases by clarification of interaction between environmental chemicals and genes of eosinophil-related protein

Research Project

Project/Area Number 17390174
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKanazawa University (2006-2007)
Kochi University (2005)

Principal Investigator

NAKAMURA Hiroyuki  Kanazawa University, Graduate School of Medical Science, Professor (30231476)

Co-Investigator(Kenkyū-buntansha) AKIMARU Kunihiro  Kochi University, School ofMedicine, Assistant Professor (50281184)
OGINO Keiki  Okayama University, Graduate School of Medicine, DentistryandPharmaceutical Sciences, Professor (70204104)
HITOMI Yoshiaki  Kanazawa University, Graduate School ofMedical Science, Associate Professor (70231545)
KAMBAYASHI Yasuhiro  Kanazawa University, Graduate School ofMedical Science, Associate Professor (20345630)
HIBINO Yuri  Kanazawa University, Graduate School ofMedical Science, Assistant Professor (40362008)
Project Period (FY) 2005 – 2007
KeywordsAllergy / Single nucleotide nolvmorohisms (SNP) of genes / Asthama / Japanese cedar nollinosis / Diesel exhaust particulate (DEP) / Eosinoohils / Asthma model mice / Prevention
Research Abstract

To propose tailor-made preventive methods for allergic diseases by clarification between environment and genes, we compared single nucleotide polymorphisms (SNP) of genes of eosinophil-related protein, e.g., CC chemokine receptor (CCR) family, Eotaxin/CCL11, Eotaxin-2/CCL24, Eotaxin-3/CCL26, Monocyte chemoattractant protein -1 (MCP-1, CCL2) between patients with asthma or Japanese cedar pollinosis and controls. We recognized significantly higher frequencies of 51 C in CCR3 gene, 2497G and 2563C in CCL26 gene, and 2518G in MCP-1 gene in patients with asthma or Japanese cedar pollinosis as compared to controls. There were significant correlations between serum levels of those proteins and severity of those allergic diseases. These results suggest the clinical significance of those eosinophils-related proteins in allergic diseases. Next, we developed the novel preventive methods for allergy, using the filter system incorporating activated carbon and amorphous iron(hydr)oxide, which efficiently removes diesel exhaust particulate (DEP). We demonstrated that removal of DEP by the filter system produced significant inhibition of allergic responses, e. g, eosinophils and neutrophils infiltration into lung tissues, lung inflammation and elevated Der f specific IgGl antibody level in asthma model mice BALB/c, which were sensitized and stimulated with Der f. Therefore, this filter system might be the most effective to prevent allergy development, if its use were started in our life as early as possible (e.g. in our infancy).

  • Research Products

    (34 results)

All 2008 2007 2006 2005

All Journal Article (24 results) (of which Peer Reviewed: 12 results) Presentation (8 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] In vitro toxicity evaluation of diesel exhaust particles on human eosinophilic cell.2008

    • Author(s)
      Hirota R, Akimaru K, Nakamura H.
    • Journal Title

      Toxicology in Vitro. 22(4)

      Pages: 988-994

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Association between physical restraint and drug-induced liver injury.2008

    • Author(s)
      Hatta K, Shibata N, Ota T, Usui C, Ito M, Nakamura H, Arai H.
    • Journal Title

      Neuropsychobiology. 56(4)

      Pages: 180-184

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] In vitro toxicity evaluation of diesel exhaust particles on human eosinophilic cell2008

    • Author(s)
      Hirota, R., Akimaru, K., Nakamura, H
    • Journal Title

      Toxicology in Vitro 22(4)

      Pages: 988-994

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association between physical restraint and drug-induced liver injury2008

    • Author(s)
      Hatta, K., Shibata, N., Ota, T., Usui, C., Ito, M., Nakamura, H., Arai, H
    • Journal Title

      Neuropsycho biology 56(4)

      Pages: 180-184

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Psychological factors including sense of coherence and some lifestyles are related to General Health Questionnaire-12(GHQ-12)in elderly workers in Japan.2007

    • Author(s)
      Matsuzaki I, Sagara T, Ohshita Y, Nagase H, Ogino K, Eboshida A, Sasahara S, Nakamura H.
    • Journal Title

      Environ Health Prev Med. 12(2)

      Pages: 71-77

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Relationship between mental health of Japanese residents and the quality of medical service.2007

    • Author(s)
      Yoshino S, Sasahara S, Maeno T, Kitaoka-Higashiguchi K, Tomotsune Y, Taniguchi K, Tomita E, Usami K, Haoka T, Nakamura H, Matsuzaki I.
    • Journal Title

      J Phys Fit Nutri Immunol. 7(1)

      Pages: 3-11

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Maximal response to electroconvulsive therapy for the treatment of catatonic symptoms.2007

    • Author(s)
      Hatta K, Miyakawa K, Ota T, Usui C, Nakamura H, Arai H.
    • Journal Title

      J ECT. 23(4)

      Pages: 233-235

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis.2007

    • Author(s)
      Nakamura H, Higashikawa F, Nobukuni Y, Miyagawa K, Endo T, Imai T, Hatta K, Ozasa K, Motohashi Y, Matsuzaki I, Sasahara S, Ogino K, Akimaru K, Eboshida A.
    • Journal Title

      Int Arch Allergy Immunol. 142(2)

      Pages: 329-334

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Psychological factors including sense of coherence and some lifestyles are related to General Health Questionnaire-12 (GHQ-l2) in elderly workers in Japan2007

    • Author(s)
      Matsuzaki, I., Sagara, T., Ohshita, Y., Nagase, H., Ogino, K., Eboshida, A., Sasahara, S., Nakamura, H
    • Journal Title

      Environ Health Prev Med 12(2)

      Pages: 71-77

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] I Relationship between mental health oflapanese residents and the quality of medical service2007

    • Author(s)
      Yoshino, S., Sasahara, S., Maeno, T., Kitaoka-Higashiguchi, K., Tomotsune, Y., Taniguchi, K., Tomita, E., Usami, K., Haoka, T., Nakamura, H., Matsuzaki
    • Journal Title

      J Phys Fit Nutri Immunot 7(1)

      Pages: 3-11

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Maximal response to electroconvulsive therapy for the treatment of catatonic symptoms2007

    • Author(s)
      Hatta, K., Miyakawa, K., Ota, T., Usui, C., Nakamura, H., Arai, H
    • Journal Title

      J ECT 23(4)

      Pages: 233-235

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis2007

    • Author(s)
      Nakamura, H., Higashikawa, F., Nobukuni, Y., Miyagawa, K., Endo, T., Imai, T., Hatta, K., Ozasa, K., Motohashi, Y., Matsuzaki, I., Sasahara, S., Ogino, K., Akimaru, K., Eboshida, A
    • Journal Title

      Int Arch Allergy Immune 142(2)

      Pages: 329-334

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Relationship between sense of coherence in the final stage of pregnancy and post-partum stress reactions.2006

    • Author(s)
      Sekizuka N, Nakamura H, Shimada K, Tabuchi N, Kameda Y, Sasano K, Sakai A.
    • Journal Title

      Environ Health Prevent Med. 11(4)

      Pages: 199-205

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Relationship between sense of coherence in the final stage of pregnancy and post-partum stress reactions2006

    • Author(s)
      Sekizuka, N., Nakamura, H., Shimada, K., Tabuchi, N., Kameda, Y., Sasano, K., Sakai, A
    • Journal Title

      Environ Health Prevent Med 11(4)

      Pages: 199-205

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Influences of the stress coping ability of supervisors on the stress situation of their subordinates.2005

    • Author(s)
      Tatsukawa H, Sasahara S, Yoshino S, Tomotsune Y, Taniguchi K, Nakamura H, Matsuzaki I.
    • Journal Title

      J Phys Fit Nutri Immunol. 15(2)

      Pages: 82-87

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Eradication of epstein-barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1.2005

    • Author(s)
      Nasimuzzaman M, Kuroda M, Dohno S, Yamamoto T, Iwatsuki K, Matsuzaki S, Mohammad R, Kumita W, Mizuguchi H, Hayakawa T, Nakamura H, Taguchi T, Wakiguchi H, Imai S.
    • Journal Title

      Mol Ther. 11(4)

      Pages: 578-590

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Psychological well-being and associated factors among elderly Hansen's disease patients in leprosaria.2005

    • Author(s)
      Kataoka M, Nakamura H.
    • Journal Title

      Environ Health Prevent Med. 10(4)

      Pages: 201-207

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] What affects the General Health Questionnaire score among former Hansen's Disease patients in leprosarium〓2005

    • Author(s)
      Kataoka M, Nakamura H.
    • Journal Title

      J Phys Fit Nutri Immunol. 15(2)

      Pages: 69-81

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Increasing prevalence of Japanese cedar pollinosis: ameta-regression analysis.2005

    • Author(s)
      Kaneko Y, Motohashi Y, Nakamura H, Endo T, Eboshida A.
    • Journal Title

      Int Arch Allergy Immunol. 136(4)

      Pages: 365-371

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Influences of the stress coping ability of supervisors on the stress situation of their subordinates2005

    • Author(s)
      Tatsukawa, H., Sasahara, S., Yoshino, S., Tomotsune, Y., Taniguchi, K., Nakamura, H., Matsuzaki, I
    • Journal Title

      J Phys Fit Nutri Inununol 15(2)

      Pages: 82-87

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Eradication of epstein-barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNAI2005

    • Author(s)
      Nasimuzzaman, M., Kuroda, M., Dohno, S., Yamamoto, T., Iwatsuki, K., Matsuzaki, S., Mohammad, R., Kumita, W., Mizuguchi, H., Hayakawa, T., Nakamura, H., Taguchi, T., Wakiguchi, H., Imai, S
    • Journal Title

      Mol Thar 11(4)

      Pages: 578-590

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Psychological well-being and associated factors among elderly Hansen's disease patients in leprosaria2005

    • Author(s)
      Kataoka, M., Nakamura, H
    • Journal Title

      Environ Health Prevent Med 10(4)

      Pages: 201-207

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] What affects the General Health Questionnaire score among former Hansen's Disease patients in leprosarium?2005

    • Author(s)
      Kataoka, M., Nakamura, H
    • Journal Title

      J Phys Fit Nutri Immunot 15(2)

      Pages: 69-81

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Increasing prevalence of Japanese cedar pollinosis : a meta-regression analysis2005

    • Author(s)
      Kaneko, Y., Motohashi, Y., Nakamura, H., Endo, T., Eboshida, A
    • Journal Title

      xInt Arch Allergy Immunot 136(4)

      Pages: 365-371

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 能登半島地震被災後に仮設住宅で暮らす高齢者の実状と健康問題に対する対策2008

    • Author(s)
      神林康弘, 中村裕之, 柴田亜樹, 林宏一
    • Organizer
      第77回日本衛生学会総会 シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      20080328-31
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 能登半島地震からみた妊産婦への支援体制2008

    • Author(s)
      日比野由利、関塚真美
    • Organizer
      第77回日本衛生学会総会 シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      20080328-31
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Prevention for the development of allergic diseases produced by environmental chemicals2008

    • Author(s)
      Nakamura, H., Hirota, R., Akimaru, K., Suganuma, N., Kang, Yumei., Sakurai, K
    • Organizer
      The 6th Special Research Project of Green Sciences, Open Symposium
    • Place of Presentation
      Kochi, Japan
    • Year and Date
      20080300
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Psychological and Physical Health and Support for the Elderly Living in Temporary Housing after Nolo-Peninsula Earthquake2008

    • Author(s)
      Kambayashi, Y., Nakamura, H., Shibata, A., Hayashi, K
    • Organizer
      The 77th Annual Meeting oflapan Society for Hygiene, Symposium
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      20080300
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Support System for the Perinatal Women : the Case of Noto-Peninsula Earthquake2008

    • Author(s)
      Hibino, Y., Sekizuka, N
    • Organizer
      The 77th Annual Meeting of Japan Society for Hygiene, Symposium
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      20080300
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 環境化学物質によるアレルギー発症を予防する2008

    • Author(s)
      中村裕之、弘田量二、秋丸国広、菅沼成文、康峪梅、櫻井克年
    • Organizer
      第6回グリーンサイエンス特別研究プロジェクト公開シンポジウム
    • Place of Presentation
      高知
    • Year and Date
      2008-03-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 免疫・アレルギーのバイオマーカーと産業保健2006

    • Author(s)
      中村裕之
    • Organizer
      第79回日本産業衛生学会 シンポジウム「バイオマーカー研究の現状と将来展望」
    • Place of Presentation
      仙台
    • Year and Date
      20060509-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Present condition and future in the biomarker researches2006

    • Author(s)
      Nakamura, H
    • Organizer
      The 79th Annual Meeting ofJapan Society for Occupational Health, Symposium
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      20060500
    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] アレルギー発症予防用フィルター2008

    • Inventor(s)
      中村裕之., 他
    • Industrial Property Rights Holder
      中村裕之., 他
    • Industrial Property Number
      特願2008-60431
    • Filing Date
      2008-03-11
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] アレルギー発症源の除去方法2006

    • Inventor(s)
      中村裕之、秋丸国広
    • Industrial Property Rights Holder
      中村裕之、秋丸国広
    • Industrial Property Number
      特願2006-084133
    • Filing Date
      2006-03-26
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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