2007 Fiscal Year Final Research Report Summary
Interactions between airway smooth murle cells and inflammatory cells in the pathogenesis of asthma
| Project/Area Number |
17390242
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Teikyo University (2006-2007)
The University of Tokyo (2005) |
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Principal Investigator |
TAKIZAWA Hajime Teikyo University, The Fourth Department of Internal Medicine, Professor (80171578)
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| Co-Investigator(Kenkyū-buntansha) |
DESAKI Masashi University of Tokyo, Department of Respiratory Medicine, Research Associate (30251250)
KOHYAMA Tadashi University of Tokyo, Department of Respiratory Medicine, Lecturer (00302703)
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| Project Period (FY) |
2005 – 2007
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| Keywords | smooth muscle cells / cell migration / cell signalling / myofibroblast / remodelin / epithelial mesench mal transition / cvtokine / TGFbeta |
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| Research Abstract |
It has been suggested that airway smooth muscle cells play important roles in the pathogenesis of asthma, but precise mechanisms remain unclear W efocused on the interactions between these structural cells and inflammatory cells such as T cells, mast cells and eosinophils Human airway smooth muscle cells express and release stem cell factor, TGF beat family molecules and and versican. These factors are believed to be chemotactic for mast cells and also be involved in airway wall remodling.IL-9, a class of Th2 type cytokine, is a potent inducer acting on airway smooth muscle cells.
Airway structural cells are once believed to be terminally differentiated cells, but recent reports strongly suggest that even these cells may change in to other type of cells. We demonstrated that human epithelial cells showed a distinct epithelial mesenchymal transition (EMT) upon stimulation of TGFbeta. These changes were induced by TNFalpha. It was suggested that dynamic interactions between airway structural cells and inflammatory cells via cytokines and growth factors play important roles in the regulation of airway remodeling in the pathogenesis of asthma. These new finding may highlight a way to develop novel type of anti-asthma drugs preventing remodeling, an irreversible airway change
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[Journal Article] Ym 1 and Ym2 expression in a mouse model exposed to diesel exhaust particles2008
Author(s)
Song, HM., Jang, AS., Ahn, MH., Takizawa, H., Lee, SH., Kwon, JH., Lee, YM, Rhim, TY., Park, CS
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Journal Title
Environ Toxicol 23(1)
Pages: 110-6
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Airway inflammatory responses to oxidative stress induced by prolonged low-dose diesel exhaust particle exposure from birth differ between mouse BALB/c and C57BL/6 strains2008
Author(s)
Li, YJ., Kawada, T., Takizawa, H., Azuma, A., Kudoh, S., Sugawara, I., Yamauchi, Y., Kohyama, T
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Journal Title
Exp Lung Res 34(3)
Pages: 125-39
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Airway inflammatory responses to oxidative stress induced by low-dose diesel exhaust particle exposure differ between mouse strains2007
Author(s)
Li, YJ., Kawada, T., Matsumoto, A., Azuma, A., Kudoh, S., Takizawa, H., Sugawara, I
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Journal Title
Exp Lung Res 33(5)
Pages: 227-44
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Repeated exposure to low-dose diesel exhaust after allergen challenge exaggerates asthmatic responses in mice2006
Author(s)
Matsumoto, A., Hiramatsu, K., Li, Y., Azuma, A., Kudoh, S., Takizawa, H., Sugawara, I
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Journal Title
Clin Immunol 121(2)
Pages: 227-35
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The effects of inhalation of diesel exhaust on murine mycobacterial infection2005
Author(s)
Hiramatsu, K., Saito, Y., Sakakibara , K., Azuma, A., Takizawa, H., Sugawara, I
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Journal Title
Exp Lung Res 31(4)
Pages: 405-15
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts2005
Author(s)
Kato, J., Kohyama, T., Okazaki, H., Desaki, M., Nagase, T., Rennard, SI., Takizawa, H
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Journal Title
Clin Immunol 117(2)
Pages: 177-81
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cytokine responsiveness in cultured human. small airway epithelial cells in relation to lung transplantation2005
Author(s)
Miyajima, K., Nakajima, S., Taguchi, M., Hayashi, A., Kajiwara, N., Uchida O., Kono, T, . Takahashi, M., Kawanishi, K., Tanaka, M., Takizawa, H., Kato, H
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Journal Title
Ann Thorac Cardiovasc Surg 11(6)
Pages: 374-81
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Additive effect of diesel exhaust particulates and ozone on airway hyperresponsiveness and inflammation in a mouse model of asthma2005
Author(s)
Jang, AS., Choi, IS., Takizawa, H., Rhim, T., Lee, JH., Park, SW, Park, CS
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Journal Title
J Koran Med Sci 20(5
Pages: 759-63
Description
「研究成果報告書概要(欧文)」より
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[Presentation] clarithromycin inhibits migration of lung fibroblast2006
Author(s)
Kohyama, T., Takizawa, H., Kato, J., Kikuchi, K., Yamauchi, Y., Takami, K., Okazaki, H., Ishii, A., Nagase, T
Organizer
The 11th Cogress of the Asian Pacific Society of respirology
Place of Presentation
Kyoto
Year and Date
20061100
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Mouse strain differences in airway inflammatory responses caused by long-time low-dose diesel exhaust exposure2006
Author(s)
Li, YJ., Takizawa, H., Azuma, A., Matsumoto, A., Kawada, T., Sugawara, I., Kudoh, S
Organizer
The 11th Cogress of the Asian Pacific Society of respirology
Place of Presentation
Kyoto
Year and Date
20061100
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Methotrexate induces proinflammatory cytokines production by human bronchial and alveolar epithelial cells2006
Author(s)
Yamauchi, Y., Okazaki, H., Desaki, M., Kohyama, T., Takizawa, H., Nagase, T
Organizer
The 11th Congress of the Asian Pacific Society of Respirology
Place of Presentation
Kyoto
Year and Date
20061100
Description
「研究成果報告書概要(欧文)」より
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