2006 Fiscal Year Final Research Report Summary
Neuroimaging investigation Vascular Depression
| Project/Area Number |
17390320
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hiroshima University |
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Principal Investigator |
YAMAWAKI Shigeto Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (40230601)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Yasumasa Graduate School of Biomedical Sciences, Assistant Professor, 大学院医歯薬学総合研究科, 講師 (70314763)
YAMASHITA Hidehisa Hiroshima University, Hospital, Assistant Professor, 病院・講師 (50294591)
TAKAMI Hiroshi Hiroshima University, Hospital, Assistant, 病院・助手
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| Project Period (FY) |
2005 – 2006
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| Keywords | Vascular Depression / Basal ganglia / Apathy / Frontal lobe / long term prognosis / dementia / Rehabilitation |
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| Research Abstract |
Growing evidence has been reported an association between cerebrovascular disease and geriatric depression. The term "vascular depression" has been used to describe a subtype of depression occurring later in, life and characterized by the brain changes that may be related depression onset.
The presence of cerebrovascular change may affect the course of depression in geriatric population. There is lots of literature about the effects of cerebrovascular change on treatment response in geriatric depression. However, few studies addressed the relationship between the presence of cerebrovascular change and long term prognosis of geriatric depression.
We have investigated
1) Relationship between location of cerebrovascular change and clinical features of the depressive symptoms in elderly patients after stroke. 2) The effects of cerebrovascular change on the course of depressive symptoms, rate of dementia and mortality approximately 10 years in geriatric depression, 3) Cerebral brain function in depressed elderly and the relationship between this brain function and the number of depressive episodes using functional magnetic resonance imaging, 4) the effects of depressive mood and loss of interest on physical functional recovery in elderly patients after stroke.
Result
1) The severity of affective depression (SDS score) was associated with left frontal lobe (but not basal ganglia) damage, and that of apathetic depression (AS score) was related to damage to the bilateral basal ganglia (but not to the frontal lobe). 2) The presence of silent cerebral infarction was associated with poor prognosis of depression in long term follow up. 3) Activation in the anterior cingulate cortex was significantly attenuated in patients who had experienced multiple depressive episodes, compared with patients with single depressive episode and control group, 4). The presence of depressive mood and loss of interest decreased physical functional recovery in elderly patients after stroke
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Research Products
(20 results)
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[Journal Article] Functional MRI investigation of cognitive impairment of depression and cognitive behavior therapy.2006
Author(s)
Kinoshita A, Okamoto Y, Ueda K, Matsunaga M, Suzuki S, Yshimura S, Shishida K, Mantani T, Yamashita H, Okada G, Yamawaki S
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Journal Title
Annual Report of Psychiatry and Pharmacotherapy 38
Pages: 48-55
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Neuroimaging Studies by fMRI about the Brain Mechanism of Emotion and Behavior : Toward Elucidatin of Pathophysiology in Depression2006
Author(s)
Okamoto Y, Okada G, Ueda K, Asahi S, Shishida K, Kinoshita A, Mantani T, Yamashita H, Yamawaki S, Tanaka S, DoYa K
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Journal Title
Japanese Journal of Psychosomatic Medicine 45,6
Pages: 439.447
Description
「研究成果報告書概要(欧文)」より
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