2006 Fiscal Year Final Research Report Summary
Diagnosis and pathogenesis of schizophrenia induced by methamphetamine
| Project/Area Number |
17390321
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nihon University |
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Principal Investigator |
KOJIMA Takuya Nihon University, School of Medicine, Professor, 医学部, 客員教授 (40014203)
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| Co-Investigator(Kenkyū-buntansha) |
MATUSHIMA Eisuke Graduate School of Tokyo Medical and Dental University, Section of Liaison Psychiatry and Palliative Medicine, Associate Professor, 医学部, 助教授 (50242186)
KURACHI Masachika University of Toyama, Faculty of Medicine, Professor, 医学部, 教授 (80019603)
ITOKAWA Masanari TOKYO INSTITUTE OF PSYCHIATRY, Schizophrenia Research Project, Project Leader, 統合失調症部門, 部門長 (40332324)
TAKAHASHI Sakae Nihon University, School of Medicine, Lecturer, 医学部, 講師 (70297802)
ARINAMI Tadao University Tsukuba, Department of Medical Genetics, Institute of Basic Medical Science, Professor, 大学院・人間総合科学研究所, 教授 (10212648)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Methamphetamine psychosis / Schizophrenia induced by methamphetamine / Schizophrenia / Exploratory eye movements / Discriminator of schizophrenia / Responsive search score / Sensitivity gene of schizophrenia / Linkage analysis |
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| Research Abstract |
Introduction : In our country methamphetamine (MAP) psychoses are thought to be caused by repetitive taking in MAP, which are different from schizophrenia. On the other hand, in Europe and America, the type with continuation of hallucination and delusion in the MAP psychoses are diagnosed as schizophrenia induced by MAP. There is a controversy between investigators of Europe and America, and Japan. 1) Study I : It was investigated if there is schizophrenia induced by MAP using exploratory eye movements, evaluation of clinical symptoms, duration of psychotic period, and analysis of schizophrenia candidate genes. Nine MAP psychoses in the Matsuzawa Metropolitan Hospital and 22 normal controls were recruited. The helpful equipment for diagnosis of schizophrenia using exploratory eye movements was used to this study which can discriminated schizophrenia from non-schizophrenia with 75% sensitivity and 80% specificity. If D value of the discrimination formula is minus the subject is decided
… More
to be schizophrenia, the discrimination formula plus, non-schizophrenia. Six of 9 MAP psychoses was D+. The clinical symptoms was worse in the D+group than in the D-group. The duration of psychotic period was longer in the D+group than the D-group. Genes of neuropeptide Y., reelin, STX were analyzed in 31 cases. The group with each risk alleles was showed higher in D value than the group without risk alleles. Study 2 : Forty nine MAP psychoses, which had recorded in Saitama Mental Health Center, were examined using schizophrenia discriminator with exploratory eye movements. Twenty eight of 49 MAP psychoses were D+ and decided to schizophrenia. Twenty one of 49 MAP psychoses were D- and decided to non-schizophrenia. The value of BPRS was higher in the D+group than in the D-group. The duration of psychotic period was longer in the D+group than in the D-group. Patients with RSS of less than 7 seven were 10 cases in the D+group. They had longest psychotic period, most sever symptoms and lower GAF value. Conclusion Results of study 1 and 2 suggested that there are patients with schizophrenia induced by overuse of methamphetamine in the MAP psychoses Less
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Research Products
(16 results)
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[Journal Article] 統合失調症の認知機能,中枢神経回路,感受性遺伝子を基盤にした新しい診断装置の開発2007
Author(s)
小島卓也, 高橋栄, 泰羅雅登, 酒谷薫, 横田正夫, 坂井禎一郎, 大久保起延, 大久保博美, 鈴木正泰, 松田哲也, 松浦雅人, 松島英介
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Journal Title
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Association Analysis of δ -Opioid Receptor Gene Polymorphisms in Methamphetamine Dependence/Psychosis2006
Author(s)
Hideaki Kobayashi, Harumi Hata, Hiroshi Ujike, Matsuo Harano, Toshiya Inada, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Norio Ozaki, Msanari Itokawa, Maki Naka, Soishiro Ide, Kazutaka Ikeda, Yohtaro Numashi, Ishiro Sora
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Journal Title
American Journal of Medical Genetics Part B 141B
Pages: 482-486
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Association Analysis of δ-Opioid Receptor Gene Polymorphisms in Methamphetamine Dependence/Psychosis2006
Author(s)
Hideaki Kobayashi, Harumi Hata, Hiroshi Ujike, Matsuo Harano, Toshiya Inada, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Norio Ozaki, Msanari Itokawa, Maki Naka, Soishiro Ide, Kazutaka Ikeda, Yohtaro Numashi, Ishiro Sora
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Journal Title
American Journal of Medical Genetics Part B 141B
Pages: 482-286
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Correlation between quan titative-EEG alterations and age in patients with interferon-alpha-treated hepatits C.2005
Author(s)
Kamei S, Oga K, Matsuura M, Tanaka N, Kojima T, Arakawa Y, Matsukawa Y, Mizutani T, Sakai T, Ohkubo H, Matsumura H, Moriyama M, Hirayanagi K.
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Journal Title
J Clin Neurophysiol Jan-Feb, 22 ・ 1
Pages: 49-52
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Correlation between quan titative-EEG alterations and age in patients with interferon-alpha-treated hepatits C.2005
Author(s)
Kamei S, Oga K, Matsuura M, Tanaka N, Kojima T, Arakawa Y, Matsukawa Y, Mizutani T, Sakai T, Ohkubo H, Matsumura H, Moriyama M, Hirayanagi K.
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Journal Title
J Clin Neurophysiol., Jan-Feb 22(1)
Pages: 49-52
Description
「研究成果報告書概要(欧文)」より
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