Development and a medical assessment of the image measurement technique by the 7T400mm grade ultrahigh magnetic field MRI

2008 Fiscal Year Final Research Report

• Project/Area Number: 17390341
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: IKEHIRA Hiroo National Institute of Radiological Sciences, 分子イメージング゛研究センター, サブグループリーダ (50150313)
• Co-Investigator(Kenkyū-buntansha): OBATA Takayuki 独立行政法人、放射線医学総合研究所, 分子イメージング゛研究センター, チームリーダ (00285107) ; AOKI Ichio 独立行政法人、放射線医学総合研究所, 分子イメージング゛研究センター, チームリーダ (10319519) ; TANADA Shuji 独立行政法人、放射線医学総合研究所, 画像医学部, 部長 (40116950)
• Co-Investigator(Renkei-kenkyūsha): OBATA Takayuki 独立行政法人、放射線医学総合研究所, 分子イメージング゛研究センター, チームリーダ (00285107) ; AOKI Ichio 独立行政法人、放射線医学総合研究所, 分子イメージング゛研究センター, チームリーダ (10319519)
• Project Period (FY): 2005 – 2008
• Keywords: 超高磁場 / 7Tesla / MRI / 多核種 / NMR

Research Abstract

今回の基盤研究では我々が開発した7Tesla/400mm級の超高磁場MRIシステムによって、超高磁場MRIでの計測技術開発と医学的評価を行うことを目的とした。
7T級超高磁場MRの医学評価の標的は、マイクロイメージングと多核種計測にあり、特に従来の臨床用装置では不可能であった酸素-17のスペクトル計測法の開発評価とともに、炭素-13に関しては3Tesla装置での臨床評価を加えて、7Tesla装置での実験的な画像計測の実用化のめどを立てることができ今後の超高磁場MRIの臨床医学研究への橋渡しができた。

Research Products

• [Journal Article] Visualization of in vivo electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance imaging, (2009)
  • Author(s): Aung U Winn, Sumitaka Hasegawa, Michiko Koshikawa, Takayuki Obata, Hiroo Ikehira, Takako Furukawa, Ichio Aoki, Tsuneo Saga
  • Journal Title: Gene Therapy doi:10.1038/gt.2009.55(2009-05-21) Pages: 1-10
• [Journal Article] SAR Computation inside Fetus by RF Coil during MR Imaging Employing Realistic Numerical Pregnant Woman Model (2009)
  • Author(s): Satoru Kikuchi, Kazuyuki Saito, Masaji Takahashi, Koichi Ito, Hiroo Ikehira
  • Journal Title: IEICE Transactions on Communications E92-B(2) Pages: 431-439
• [Journal Article] Effects of chewing in working memory processing (2008)
  • Author(s): Yoshiyuki Hirano, Takayuki Obata, Kenichi Kashikura, Hiroi Nonaka, Atsumichi Tachibana, Hiroo Ikehira, Minoru Onozuka
  • Journal Title: Neuroscience Letters 436(2), doi:10.1016/j.neulet.2008.03.033(2008-03-16) Pages: 189-192
• [Journal Article] et.al: Negative correlation between brain glutathione level and negative symptoms in schizophrenia (2008)
  • Author(s): Daisuke Matsuzawa, Takayuki Obata, Hiroi Nonaka, Yoko Kanazawa, Eiji Yoshitome, Tsuyoshi Matsuda, Keiji Shimizu, Hiroo Ikehira, Masaomi Iyo, Kenji Hashimoto
  • Journal Title: A 3T 1H-MRS study, PLoSONE (Online only:URL:http:// www. Plosone.org) doi:10.1371/journal.pone .0001944(2008-04-09), 3(4) Pages: e1944-1-e1944-6
• [Journal Article] ADC value and diffusion tensor imaging of prostate cancer: Changes in carbon-ion radiotherapy (2008)
  • Author(s): Yukihisa Takayama, Riwa Kishimoto, Syouhei Hanaoka, Hiroi Nonaka, Susumu Kandatsu, Hiroshi Tsuji, Hirohiko Tsujii, Hiroo Ikehira, Takayuki Obata
  • Journal Title: Journal of Magnetic Resonance Imaging : JMRI 27(6) Pages: 1331-1335
  • URL: http://www3.interscience.wiley.com/cgi-bin/fulltext/119426851/HTMLSTART(2008-05-26), 27(6), 1331-1335
• [Journal Article] Reduciton of a High-field Dielectric Artifact with Homemade Gel (2008)
  • Author(s): Yukihisa Takayama, Hiroi Nonaka, Manabu Nakajima, Takayuki Obata, Hiroo Ikehira
  • Journal Title: Magnetic Resonance in Medical Sciences 7(1) Pages: 37-41
• [Journal Article] Magnetic resonance cholangiopancreatography: potential usefulness of dehydrocholic acid (DHCA) administration in the evaluation of anastomotic site (2008)
  • Author(s): Yuji Sakai, Hiroi Nonaka, Hiroo Ikehira, Takayuki Obata, Masaru Miyazaki, et.al
  • Journal Title: Hepato-Gastroenterology 55(81) Pages: 17-20
• [Journal Article] Magnetic resonance cholangiopancreatography: potential usefulness of dehydrocholic acid(DHCA) administration in the evaluation of biliary disease (2008)
  • Author(s): Yuji Sakai, Toshio Tsuyuguchi*, Hiroi Nonaka, Hiroo Ikehira, Takayuki Obata, Osamu Yokosuka, Masaru Miyazaki, et.al
  • Journal Title: Hepato-Gastroenterology 55(82-83) Pages: 323-328
• [Journal Article] A new approach for diagnosis of hepatolithiasis: magnetic resonance cholangiopancreatography: potential usefulness of dehydrocholic acid (DHCA) administration in the evaluation of hepatolithiasis (2008)
  • Author(s): Yuji Sakai, Toshio Tsuyuguchi*, Harutosi Sugiyama*, Yoshihiro Fukuda*, Masaaki Ebara*, Hiroi Nonaka, Hiroo Ikehira, Takayuki Obata, Osamu Yokosuka, Masaru Miyazaki, et.al
  • Journal Title: Hepato-Gastroenterology 55(86-87) Pages: 1801-1805
• [Journal Article] Modification of nitroxyl contrast agents with multiple spins and their proton T1 relaxivity (2008)
  • Author(s): Kenichiro Matsumoto, Haruko Yakumaru, Michiko Narazaki, Hidehiko Nakagawa, Kazunori Anzai, Hiroo Ikehira, Nobuo Ikota
  • Journal Title: Magnetic Resonance Imaging 26(1) Pages: 117-121
• [Journal Article] Evaluating glycogen signal contamination in muscle by 13C MRS of the liver (2008)
  • Author(s): Moyoko Tomiyasu, Takayuki Obata, Hiroi Nonaka, Yukio Nishi, Hiromitsu Nakamoto, Yukihisa Takayama, Hiroo Ikehira, Iwao Kanno
  • Journal Title: Magnetic Resonance Imaging 26(4)doi:10.1016/j.mri.2007.09.002(2008-02-20) Pages: 572-576
• [Journal Article] MRスペクトロスコピーを元に (2007)
  • Author(s): 金沢 洋子、池平 博夫
  • Journal Title: 映像情報 MEDICAL Pages: 358-364
• [Journal Article] In vivo mapping of substance P receptors in brains of laboratory animals by high-resolution imagingsystems (2007)
  • Author(s): Eisuke Haneda, Makoto Higuchi, Jun Maeda, Motoki Inaji, Takashi Okauchi, Kiyoshi Andou, Shigeru Obayashi, Yuji Nagai, Michiko Narazaki, Hiroo Ikehira, Ryuji Nakao, Ming-Rong Zhang, Kazutoshi Suzuki, Hidenori Suzuki*, Tetsuya Suhara
  • Journal Title: Synapse 61(4) Pages: 205-215
• [Journal Article] Altered brain activation by a false recognition task in young abstinent patients with alcohol dependence, Alcoholism (2007)
  • Author(s): Yoshihide Akine, Motoichiro Kato, Taro Muramatsu, Satoshi Umeda, Masaru Mimura, Yoshiyuki Asai, Shuji Tanada, Takayuki Obata, Hiroo Ikehira, Haruo Kashima*, Tetsuya Suhara
  • Journal Title: Clinical and Experimental Research vol31(9) Pages: 1589-1597
• [Journal Article] Comparisons of EPR imaging and T(1)-weighted MRI for efficient imaging of nitroxyl contrast agents (2007)
  • Author(s): Kenichiro Matsumoto, Michiko Narazaki, Hiroo Ikehira, Kazunori Anzai,Nobuo Ikota
  • Journal Title: Journal of Magnetic Resonance 187(1) Pages: 155-162
• [Journal Article] Development of a Patch Antenna Array RF Coil for Ultra-high Field MRI (2007)
  • Author(s): Manabu Nakajima, Iwao Nakajima, Shigeru Obayashi, Yuji Nagai, Takayuki Obata, Yoshiyuki Hirano, Hiroo Ikehira
  • Journal Title: Magnetic Resonance in Medical Sciences 6(4) Pages: 231-233
• [Journal Article] Laterality and aging of thalamic subregions measured by diffusion tensor imaging (2007)
  • Author(s): Miho Ota, Takayuki Obata, Yoshihide Akine, Hiroshi Ito, Ryohei Matsumoto, Hiroo Ikehira, Tetsuya Suhara, et.al:
  • Journal Title: Neuroreport 18(10) Pages: 1071-1075
• [Journal Article] Optimizing T2-weighted magnetic resonance sequences for surface coil microimaging of the eye with regard to lid (2006)
  • Author(s): Takayuki Obata, Koji Uemura, Hiroi Nonaka, Mitsuru Tamura, Shuji Tanada, Hiroo Ikehira
  • Journal Title: eyeball and head moving artifacts, Magnetic Resonance Imaging 24(1) Pages: 97-101
• [Journal Article] Age-related degeneration of corpus callosum measured with diffusion tensor imaging (2006)
  • Author(s): Miho Ota, Takayuki Obata, Yoshihide Akine, Hiroshi Ito, Hiroo Ikehira, Takashi Asada, Tetsuya Suhara
  • Journal Title: NeuroImage 31(4) Pages: 1445-1452
• [Journal Article] Quantitative magnetic resonance spectroscopy of schizophrenia: relationship between decreased N-acetylaspartate and frontal lobe dysfunction (2006)
  • Author(s): Youko Tanaka, Takayuki Obata, Takeshi Sassa, Eiji Yoshitome, Yoshiyuki Asai, Hiroo Ikehira, Tetsuya Suhara, Yoshiro Okubo, Touru Nishikawa
  • Journal Title: Psychiatry and Clinical Neurosciences 60(3) Pages: 365-372
• [Journal Article] Delayed Gadolinium-enhanced MR to Determine Glycosaminoglycan Concentration in Reparative Cartilage after Autologous Chondrocyte Implantation: Preliminary Results1 (2006)
  • Author(s): Atsuya Watanabe, Yuichi Wada, Takayuki Obata, Takuya Ueda, Mitsuru Tamura, Hiroo Ikehira, Hideshige Moriya
  • Journal Title: Radiology 239(1) Pages: 201-208
• [Journal Article] MR多核種イメージング (2006)
  • Author(s): 楢崎 美智子、金沢 洋子、池平 博夫
  • Journal Title: 放射線科学 49(12) Pages: 431-435
• [Journal Article] Time course Evaluation of Reparative Cartilage with MR Imaging after Autologous Chondrocyte Implantation (2005)
  • Author(s): Atsuya Watanabe, Yuichi Wada*, Takayuki Obata, Takuya Ueda, Mitsuru Tamura, Hiroo Ikehira, Hideshige Moriya, et.al
  • Journal Title: Cell Transplantation 14(9) Pages: 695-700
• [Journal Article] Development of high-radiation-sensitive polymer gel for magnetic resonance imaging in three-dimensional dosimetry (2005)
  • Author(s): Shinichiro Mori, Masahiro Endo, Shigeo Furukawa, Masayoshi Sunaoka, Hiroi Nonaka, Takayoshi Ishii, Hiroo Ikehira
  • Journal Title: Magnetic Resonance Imaging 23(5) Pages: 691-694
• [Journal Article] Phosphorous-31 magnetic resonance spectroscopy of cervical cancer using transvaginal surface coil (2005)
  • Author(s): Takuya Morimoto, Takayuki Obata, Tatsuya Ohno, Yoshiyuki Suzuki, Hiroo Ikehira, Tetsuya Suhara, Shigeo Furukawa, Hirohiko Tsujii, Takashi Nakano
  • Journal Title: Magnetic Resonance in Medical Sciences 4(4) Pages: 197-201
• [Journal Article] Functional network in the prefrontal cortex during episodic memory retrieval (2005)
  • Author(s): Satoshi Umeda, Yoshihide Akine, Motoichiro Kato, Taro Muramatsu, Masaru Mimura, Susumu Kandatsu, Shuji Tanada, Takayuki Obata, Hiroo Ikehira, Tetsuya Suhara
  • Journal Title: NeuroImage 26(3) Pages: 932-940
• [Journal Article] Metabolic activity in skeletal muscles of patients with non-hypoxaemic chronic obstructive pulmonary disease studied by 31P-magnetic resonance spectroscopy (2005)
  • Author(s): Tomoko Hamaoka, Hiroo Ikehira, Takayuki Obata, Shuji Tanada, Yasuhito Sasaki, et.al
  • Journal Title: Respirology, 10(2) Pages: 164-170
• [Journal Article] Monitoring of liver glycogen synthesis in diabetic patients using carbon-13 MR spectroscopy
  • Author(s): Moyoko Tomiyasu, Takayuki Obata, Yukio Nishi, Hiromitsu Nakamoto, Hiroi Nonaka, Yukihisa Takayama, Autio Joonas, Hiroo Ikehira, Iwao Kanno
  • Journal Title: European Journal of Radiology doi:10.1016/j.ejrad.2008.10.019 (2008-12-05)
• [Presentation] 酸素代謝速度計測に向けたマウス17-O MRI計測 -第2報- (2008)
  • Author(s): 楢崎 美智子、金沢 洋子、小池 幸子、安藤 興一、池平 博夫
  • Organizer: 日本磁気共鳴医学会雑誌、28(1),82-84
  • Year and Date: 20080000
• [Presentation] Calculation of Temperature Rise Distribution in Pregnant Woman Model Exposed to RF Pulses during MR Imaging (2008)
  • Author(s): Satoru Kikuchi, Kazuyuki Saito, Masaharu Takahashi, Koichi Ito, Hiroo Ikehira
  • Organizer: 354-357
  • Year and Date: 20080000
• [Presentation] Monitoring of glycogen synthesis in liver of diabetic patients using 13C-MR spectroscopy (2007)
  • Author(s): Moyoko Tomiyasu, Takayuki Obata, Yukio Nishi, Hiromitsu Nakamoto, Hiroi Nonaka, Yukihisa Takayama, Hiroo Ikehira, Iwao Kanno
  • Organizer: Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition, 15, 525
  • Year and Date: 20070000
• [Presentation] et.al: 19F high senseitivity imaging for in vivo drug dynamics in mice at 7T with 5-FU, Proceedings of the International Society for Magnetic Resonance in Medicine (2006)
  • Author(s): Yoko Kanazawa, Yoshiyuki Hirano, Sachiko Koike, Michiko Narazaki, Eiji Yoshitome, Koichi Ando, Hiroo Ikehira
  • Organizer: Scientific Meeting and Exhibition, 14, 3094
  • Year and Date: 20060000
• [Presentation] 17O imaging for the evaluation of physiological function in the tumor bearing mice (2006)
  • Author(s): Michiko Narazaki, Yoko Kanazawa, Sachiko Koike, Koichi Ando, Hiroo Ikehira
  • Organizer: Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition, 14, 3113,
  • Year and Date: 20060000