2007 Fiscal Year Final Research Report Summary
Development of Cell Selective particle irradiation using epithermal neutron beam for malignant brain tumor.
| Project/Area Number |
17390390
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MATSUMURA Akira University of Tsukuba, Graduate School of Comprehensive Human Science, Professor (90241819)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tetsuya University of Tsukuba, Graduate School of Comprehensive Human Science, Assistant Professor (30375505)
SHIBATA Yasushi University of Tsukuba, Graduate School of Comprehensive Human Science, Assistant Professor (50400685)
KAGEJI Teruyoshi University of Tsukuba, Department of Neurosurgery, Assistant Professor (70294684)
KUMADA Hiroaki Japan Atomic Energy Agency, Departmentof Research Reactor and TandemAccelerator, Researcher (30354913)
ISOBE Tomonori University of Tsukuba, Graduate School of Comprehensive Human Science, Assistant Professor (70383643)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Glioma / BNCT / Boron / Neutron / Brain Tumor |
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| Research Abstract |
Clinical trial of BNCT for Glioblastoma
Eight patients with histological proven glioblastoma with an average age of 65 years (range 32-76, M:F=2:6) were underwent BNCF with new protocol which add 30Gy X ray irradiation after BNCT. 7 patients were treated with intra-operative BNCT before the protocol. In these 15 cases, 5 cases are alive; the average post BNCT follow up period was 20.3 months. Time to progression was 11.9 months, overall survival was 25.3 months. Adverse event (Grade 3>) were seen in 2 cases; convulsion and brain swelling (1 case) and transient oculomotor palsy (1 case). These result superior to standard treatments and suggest the effectiveness of the BNCT for malignant glioma
MR spectroscopy
For estimating absolute concentration of boron compounds in tissue, proton MR spectroscopy (MRS) was applied to quantify phenylalanine and L-p-boronophenylalanine (BPA). We could identify several characteristic resonances, peak of 7.32ppm (phenylalanine), four peak ranged 7.1 ppm to 7.6 ppm (BPA). A water phantom were used, and absolute concentration were obtained by proton MRS using a tissue water signal as an internal standards. These methods have high correlation between the calculated concentrations based on MRS and the known concentration. (R=0.99: phenylalanine and BPA).
These clinical results appear to encouraging, but the effectiveness of the invading tumor cells are still unclear. Improved tumor targeting boron delivery and neutron distribution will enhance the therapeutic effectiveness of BNCT.
MR spectroscopy results indicate that proton MRS can be non-invasive and potentially useful technique for BPA quantification in BNCT.
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[Journal Article] Demonstration of inter-and intracellular distribution of boron and gadolinium using micro-proton-induced X-ray emission(Micro-PIXE)2006
Author(s)
Endo K, Yamamoto T, Shibata Y, Tsuboi K, Matsumura A, Kumada H, Yamamoto K, Sakai T, Sato T, Oikawa M, Ohara Y, Ishii K
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Journal Title
Oncol Res 16
Pages: 57-65
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Prognostic factor of glioblastoma2008
Author(s)
Sakamoto S, Yamamoto T, Takano S, Shibata Y, Nakai K, Matsuda M, Matsumura A
Organizer
25th Annual meetings of the Tsukuba Society for Neurosurgery
Year and Date
2008-02-03
Description
「研究成果報告書概要(欧文)」より
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[Presentation] High-dose radiation therapy for glioblastoma2007
Author(s)
Yamamoto T, Nakai K, Matsuda M, Takano S, Shibata Y, Tsurubuchi T, Tokuue K, Tsuboi K, Matsumura A
Organizer
5th Meeting of The Asian Society for Neuro-Oncology
Place of Presentation
Instanbul
Year and Date
20071102-04
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Histopathological evaluation of glioblastoma after high-dose radiation therapy2007
Author(s)
Tsurubuchi T, Yamamoto T, Enomoto T, Sato M, Sakamoto N, Matsuda M, Marushima A, Nakai K, Saito A, Shibata Y, Tsuboi K, Matsumura A
Organizer
5th Meeting of The Asian Society for Neuro-Oncology
Place of Presentation
Instanbul
Year and Date
20071102-04
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Histopathological evaluation of glioblastoma after high-dose radiation therapy2007
Author(s)
Tsurubuchi T, Yamamoto T, Enomoto T, Sato M, Sakamoto N, Matsuda M, Marushima A, Nakai K, Saito A, Shibata Y, Tsuboi K, Matsumura. A
Organizer
Young Researcher BNCT Meeting
Place of Presentation
Birmingham
Year and Date
2007-09-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Histopathological evaluation of glioblastoma after high dose radiation therapy2007
Author(s)
Tsurubuchi T, Yamamoto T, Sato H, Sakamoto N, Matsuda M, Marushima A, Nakai K, Saito A, Shibata Y, Takano S, Tsuboi K, Matsumura A
Organizer
4th Congress on Neutron Capture Therapy
Year and Date
2007-08-25
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Clinical results of Glioblastoma treatment before and after the adoption of BNCT and proton beam irradiation2007
Author(s)
Yamamoto T, Matsuda M, Endo K, Nakai K, Tsuboi K, Takano S, Shibata Y, Matsumura A, Tokuue K, Akine Y, Kageji T, Kumada H, Kisi T
Organizer
Scientific meeting of medical treatment system using neutron beam and particle irradiation
Year and Date
2007-02-04
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Non-invasive measurement of p-Boronophenylalanine using proton MR Spectroscopy2007
Author(s)
Isobe T, Matsumura A, Anno I, Shibata Y, Yamamoto T, Hirano Y, Ozaki M, Fujibuchi T, Isobe T, Muraishi H, Yoda K, Umeda T
Organizer
Rep. of China Japan Korea International Joint conference for radiological technologists
Place of Presentation
Taipei
Year and Date
2007-01-15
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A new NEDO research project towards hospital based accelerator BNCT using advanced DDS system2006
Author(s)
Akira Matsumura, Yoshihiro Mori, Yasufumi Kaneda, Kazuyuki Hashimoto, Kei Nakai, Tetsuya Yamamoto, Hiroyuki Nakamura, Ken Akamatsu, Thmoyuki Asano, Senman Lee, Yoshinori Sakurai, Hiroyuki Kumada, Kazuyoshi Yamamoto, Yasushi Shibata, Tokushi Shibata, Toro Nakahara, Masafumi Mutoh, Hisaharu Sakae, Yoshimasa Yuasa, Yasuo Satoh,Hiroaki Sakurabata, Satoshi Muraki, Takahisa Nagayama
Organizer
12th International congress on neutron capture therapy
Place of Presentation
Kagawa
Year and Date
20060909-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Analysis of born distribution in 9L gliosarcoma cells using particle induced r-ray emission(PIGE)2006
Author(s)
Kiyoshi Endo, Tetsuya Yamamoto, Yasushi Shibata, Koji Tsuboi, Akira Matsumura, Hiroaki Kumada, Kazuyoshi Yamamoto, Takuro Sakai, Takahiro Sato, Masakazu Oikawa, Yoshihiro Ohara, Keizo Ishii
Organizer
12th International congress on neutron capture therapy
Place of Presentation
Kagawa
Year and Date
20060909-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] BNCT using JRR-4 and future plan2006
Author(s)
Yamamoto T, Matsuda M, Nakai K, Endo K, Matsumura A
Organizer
Scientific meeting of medical treatment system using neutron beam and particle irradiation
Year and Date
2006-02-25
Description
「研究成果報告書概要(欧文)」より
