2007 Fiscal Year Final Research Report Summary
The similarity between pregnant immunity and tumor immunity
| Project/Area Number |
17390447
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
SAITO Shigeru University of Toyama, Obstetrics and Gynecology, Professor (30175351)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takafumi University of Toyama, Obstetrics and Gynecology, Associate Professor (20303969)
WAKASUGI Satomi University of Toyama, Obstetrics and Gynecology, Assistant Professor (90361956)
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| Project Period (FY) |
2005 – 2007
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| Keywords | pregnancy / tumor / immunology / IDO / regulatory T cell / regulatory NK cell / tolerance / 婦人科腫瘍 |
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| Research Abstract |
Fetus is a semiallograft to maternal host, therefore immune-tolerance system should be present during pregnancy. Inadequate tolerance induction might induce miscarriage or pregnancy induced hypertension (PIH). Tumor cells also escape the immunological attack, therefore there are many similarity between pregnancy immunity and tumor immunity. From the view point of pregnancy immunity, we found that C1D4^+ CD25^+ regulatory T (Treg) cells are increased at materno - fetal interface, and these cells are decreased in miscarriage and PIH cases. We also clarified that indoleamine 2,3-dioxygenase (IDO) expressing dendritic cells (DC) and macrophage play very important roles for maintenance of pregnancy. In cervical cancer, IDO expression in tumor cells, appeared in cervical intraepithelial neoplasia (CIN) - 3 of the uterine cervix and marked expression in microinvasive cancer cells was observed. Interestingly, IDO expression was confined to the cancer cells at the invasive front. Moreover antigen - presenting cell at the invasive front in primary and metastatic lesions were also expressing IDO. Treg cells appeared in CIN - 3 and increased in microinvasive and invasive cancer. A network between IDO and Treg cells might induce the induction of immune escape.
We found immunoregulatory NK cells using leukemic mice model The surface markers of regulatory NK cells are CD94^-, acialo GMI^+, CD25^(++), CD122^(++), Thy 1, 2^(++), c - kit^+, CD3^-, DX5^+. These NK cells produced TGF - β and inhibited MEIC class II antigens on DC, and inhibited the induction of cytotoxic T cell. Interestingly, these NK cells were increased in the pregnancy uterus in mice. These NK cells were also detected in pregnancy NOD / SCID mice. We discovered these regulatory NK cells from the tumor bearing mice and pregnant mice. We confirm the similarity between tumor immunity and pregnant immunity.
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Research Products
(68 results)
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[Journal Article] Interleukin(IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells2008
Author(s)
Hirata T, Osuga Y, Hamasaki K, Yoshino O, Ito M, Hasegawa A, Takemura Y, Hirota Y, Nose E, Morimoto C, Harada M, Koga K, Tajima T, Saito S, Yano T, Taketani Y
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Journal Title
Endocrinology 149
Pages: 1260-1267
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells2008
Author(s)
Hashimoto I, Koizumi K, Tatematsu M, Minami T, Cho S, Takeno N, Nakashima A, Sakurai H, Saito S, Tsukada K, Saiki I
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Journal Title
Eur J Cancer 44
Pages: 1022-1029
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells2008
Author(s)
Hashimoto, I, Koizumi, K, Tatematsu, M, Minami, T, Cho, S, Takeno, N, Nakashima, A, Sakurai, H, Saito, S, Tsukada, K, Saiki, I
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Journal Title
Eur J Cancer 44
Pages: 1022-1029
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes2007
Author(s)
Yoneda, S, Sakai, M, Sasaki, Y, Shiozaki, A, Hidaka, T, Saito, S
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Journal Title
J Obstet Gynaecol Res 33
Pages: 38-44
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Proportion of peripheral blood-and decidual- CD4^+CD25^<b right> regulatory T cells in pre-eclampsia2007
Author(s)
Sasaki, Y, Darmochwal-Kolarz, D, Suzuki, D, Sakai, M, Ito, M, Shima, T, Shiozaki, A, Rolinski, J, Saito, S
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Journal Title
Clin Exp Immunol 149
Pages: 139-145
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Epression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer2007
Author(s)
Nakamura, T, Shima, T, Saeki, A, Hidaka, T, Nakashima, A, Takikawa, O, Saito, S
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Journal Title
Cancer Science 98
Pages: 874-881
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Activated T lymphocytes in pre-eclampsia2007
Author(s)
Darmochwal-Kolarz, D, Saito, S, Rolinski, J, Tabarkiewicz, J, Kolarz, B, Leszczynska-Gorzelak, B, Oleszczuk, J
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Journal Title
Am J Reprod Immunol 58
Pages: 39-45
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] What is the role of regulatory T cells in the success of implantation and early pregnancy?2007
Author(s)
Saito, S, Shima, T, Nakashima, A, Shiozaki, A, Ito, M, Sasaki, Y
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Journal Title
J Assist Reprod Genet 24
Pages: 379-386
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Tolerance signaling molecules and pregnancy: IDO, galectins, and Renaissance of regulatory T cells2007
Author(s)
Ternes,s P, Kallikourdis, M, Betz, AG, Rabinovich, GA, Saito, S, Clark, DA
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Journal Title
Am J Reprod Immunol 58
Pages: 235-254
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Regulatory T cells and regulatory natural killer(NK)cells play important roles in feto-maternal tolerance2007
Author(s)
Saito, S, Shiozaki, A, Sasaki, Y, Nakashima, A, Shima, T, Ito, M
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Journal Title
Semin Immunol Pathol 29
Pages: 115-122
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Interleukin(IL)-17A Stimulates IL - 8 Secretion, Cyclooxygensase - 2 Expression, and Cell Proliferation of Endometriotic Stromal Cells2007
Author(s)
Hirata, T, Osuga, Y, Hamasaki, K, Yoshino, O, Ito, M, Hasegawa, A, Takemura, Y, Hirota, Y, Nose, E, Morimoto, C, Harada, M, Koga, K, Tajima, T, Saito, S, Yano, T, Taketani, Y
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Journal Title
Endocrinology 149
Pages: 1260-1267
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Characterization of natural killer cells in nonobese diabetic / severely compromised immunodeficient mice during pregnancy
Author(s)
Lin, Y, Zhong, Y, Saito, S, Chen, Y, Shen, W, Di, J, Zeng, S
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Granulysin produced by uterine natural killer cell induces apoptosis of extravillous trophoblasts in spontaneous abortion
Author(s)
Nakashima, A, Shiozaki, A, Myojo, S, Ito, M, Tatematsu, M, Sakai, M, Takamori, Y, Ogawa, K, Nagata, K, Saito, S
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Regulatory T cells are needed to maintenance of allograftic pregnancy in early pregnant mice, but not mid or late pregnant mice2007
Author(s)
Ito, M, Sasaki, Y, Nakashima, A, Shima, T, Saito, S
Organizer
22nd Japan Soc. for Immunology of of Reproduction
Place of Presentation
Tokyo
Year and Date
20071100
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A case of Th2 type preeclampsia showing prolonged proteinuria2007
Author(s)
Shiozaki, A, Hashimoto, Y, Yoneda, N, Tatematsu, M, Ina, S, Inasaka, J, Wakasugi, S, Yoneda, S, Saito, S
Organizer
28th Japan Soc. Pregnant induced hypertension
Place of Presentation
Ehime
Year and Date
20071000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The different clinical process between Thi type preeclampsia and Th2 type preeclampsia2007
Author(s)
Shiozaki, A, Sakai, M, Tabata, M, Tatematsu, M, Sasaki, Y, Okada, T, Saito, S
Organizer
43rd Japan Soc Perinatal and Neonatal Medicine
Place of Presentation
Tokyo
Year and Date
20070700
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The autophagy in extravillous trpphoblast in early pregnancy2007
Author(s)
Tatematsu, M, Nakashima, A, Yoshida, T, Nikaido, T, Yoshimori, T, Saito S
Organizer
9th Hokushinetsu Tateyama Seminar
Place of Presentation
Ishikawa
Year and Date
20070700
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Proportion of peripheral blood and decidual-CD4^+CD25brightregulatory T cells and the expression of Toll like receptor 4 on interstitial extravillous trophoblast in pre-eclampsia2007
Author(s)
Ito, M, Sasaki, Y, Suzuki, D, Sakai, M, Shima, T, Shiozaki, A, Saito, S, Darmochwal-Kolarz, D
Organizer
Xth International Congress of Reproductive Immunology
Place of Presentation
Opatija
Year and Date
20070600
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The different clinical process between Thl type preeclampsia and Th2 type preeclampsia2007
Author(s)
Shiozaki, A, Sakai, M, Ito, M, Tatematsu, M, Sasaki, Y, Okada, T, Saito, S
Organizer
59th Japan Soc Obstet Gynecol
Place of Presentation
Kyoto
Year and Date
20070400
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Regulatory T cells in the ascites of endomeriosis cases2007
Author(s)
Ito, M, Hidaka, T, Wakasugi, S, Nagira, K, Nakashima, A, Saito, S
Organizer
59th Japan Soc Obstet Gynecol
Place of Presentation
Kyoto
Year and Date
20070400
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The relationship between neonatal immunity and fetal environment in LPS treated iNOS knock out mice2007
Author(s)
Takahashi, H, Sugawara, N, Okawa, T, Fujimori, K, Yamada, H, Sato, A, Sasaki, Y, Saito, S
Organizer
59th Japan Soc Obstet Gynecol
Place of Presentation
Kyoto
Year and Date
20070400
Description
「研究成果報告書概要(欧文)」より
