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2007 Fiscal Year Final Research Report Summary

Establishment of novel cancer therapy using telomerase-specific replication competent adenovirus

Research Project

Project/Area Number 17390449
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKanazawa University

Principal Investigator

KYO Satoru  Kanazawa University, Graduate School Of Medical Science, Associate Prof. (50272969)

Co-Investigator(Kenkyū-buntansha) INOUE Masaki  Kanazawa University, Graduate School Of Medical Science, Prof (10127186)
Project Period (FY) 2005 – 2007
KeywordsVirotheranv / Replication-competent adenovirus / hTERT nromntnr
Research Abstract

We previously cloned the promoter of human reverse transcriptase (hTERT) gene, a catalytic subunit of human telomerase, which was found to be active only in cancer cells with telomerase activity, while it was silent in most normal cells without telomerase activity. We have planned to insert this promoter into the upstream of the El gene of Adenovirus type 5 genome so that adenovirus El gene is efficiently expressed only in cancer cells. Eventually, this chimera virus can replicate only in cancer cells with high levels of expression of El gene, which is required for viral replication. We named this virus TRAD: telomerase-specific replication adenovirus. In the present project, we examined the in vitro and in vivo efficacy of TARD directly injected into primary site of tumors. We found that TARD was effective to reduce tumor burden without exhibiting any severe adverse effect, such as myelosurpression or liver dysfunction caused by viral toxicity Therefore, we propose the clinical use of this virus.

  • Research Products

    (9 results)

All 2007

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Concomitant activation of AKT with ERK1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosis2007

    • Author(s)
      Mori N, Kyo S, et. al.
    • Journal Title

      Cancer Sci. 98

      Pages: 1881-1888

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis2007

    • Author(s)
      Mizumoto Y, Kyo S, et. al.
    • Journal Title

      Cancer Sci. 98

      Pages: 652-658

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The Telomerase Reverse Transcriptase(hTERT)Gene is a Direct Target of the Histone Methyltransferase SMYD32007

    • Author(s)
      Liu C, Fang X, Ge Z, Jalink M, Kyo S, et. al.
    • Journal Title

      Cancer Res 67

      Pages: 2626-2631

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Concomitant activation of AKT with ERKI/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosis2007

    • Author(s)
      Mori, N., Kyo, S., et. al.
    • Journal Title

      Cancer Sci 98

      Pages: 1881-1888

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis2007

    • Author(s)
      Mizumoto, Y., Kyo, S., et. al.
    • Journal Title

      Cancer Sci 98

      Pages: 652-658

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The Telomerase Reverse Transcriptase (hTERT) Gene is a Direct Target of the Histone Methyltransferase SMYD32007

    • Author(s)
      Liu, C., Fang, X., Ge, Z., Jalink, M., Kyo, S., et. al.
    • Journal Title

      Cancer Res 67

      Pages: 2626-2631

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Recent advances in telomerase-based medicine in gynecologic tumors.2007

    • Author(s)
      Kyo S
    • Organizer
      The 59th Japan Society of Obstetrics and Gynecology
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-04-02
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Recent advances in telomerase-based medicine in gynecologic tumors2007

    • Author(s)
      Kyo, S
    • Organizer
      The 59th Japan Society of Obstetrics and Gynecology
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-04-02
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Reproductive Oncology2007

    • Author(s)
      Kyo S.(分担執筆)
    • Total Pages
      22
    • Publisher
      Research Singpost
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2010-02-04  

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