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2008 Fiscal Year Final Research Report

Molecular-genetic analysis of age related hearing impairment

Research Project

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Project/Area Number 17390459
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionShinshu University

Principal Investigator

USAMI Shin-ichi  Shinshu University, 医学部, 教授 (10184996)

Co-Investigator(Kenkyū-buntansha) TAKUMI Yutaka  信州大学, 医学部, 講師 (70312501)
HIGUCHI Kyouichi  信州大学, 医学系・研究科, 教授 (20173156)
Co-Investigator(Renkei-kenkyūsha) TAKUMI Yutaka  信州大学, 医学部, 講師 (70312501)
HIGUCHI Kyouichi  信州大学, 医学系・研究科, 教授 (20173156)
Project Period (FY) 2005 – 2008
Keywords老人性難聴 / 遺伝子 / 内耳 / 加齢 / SNPs
Research Abstract

高齢化社会の抱える問題の一つとして、老人性難聴によるコミュニケーション障害がある。老人性難聴は、従来から環境要因と遺伝的要因が関与していることが推測されているが、そのメカニズムはほとんど明らかになっていない。本研究では老人性難聴のメカニズムの推定を目的とし、健康な高齢者400名を対象に聴力測定と、候補遺伝子のSNPsの解析を行った。その結果、老人性難聴と有意に相関のある老人性難聴候補遺伝子を2種類見出した。

  • Research Products

    (25 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] The localization of proteins encoded by CRYM, KIAA1199, UBA52, COL9A3, and COL9A1, genes highly expressed in the cochlea2008

    • Author(s)
      Usami S, Takumi Y, Suzuki N, Oguchi T, Oshima A, Suzuki H, Kitoh R, Abe S, Sasaki A, Matsubara A
    • Journal Title

      Neuroscience 154(1)

      Pages: 22-8

    • Peer Reviewed
  • [Journal Article] Kimberling WJ.Mutation profile of the CDH23 gene in 56 probands with Usher syndrome type I2008

    • Author(s)
      Oshima A, Jaijo T, Aller E, Millan JM, Carney C, Usami S, Moller C
    • Journal Title

      Hum Mutat 29(6)

      Pages: E37-46

    • Peer Reviewed
  • [Journal Article] The responsible genes in Japanese deafness patients and clinical application using Invader assay2008

    • Author(s)
      Usami S, Wagatsuma M, Fukuoka H, Suzuki H, Tsukada K, Nishio S, Takumi Y, Abe S
    • Journal Title

      Acta Otolaryngol 128(4)

      Pages: 0446-54

    • Peer Reviewed
  • [Journal Article] micro-Crystallin as an intracellular 3,5,3'-triiodothyronine holder in vivo2007

    • Author(s)
      Suzuki S, Suzuki N, Mori J, Oshima A, Usami S, Hashizume K
    • Journal Title

      Mol Endocrinol 21(4)

      Pages: 885-94

    • Peer Reviewed
  • [Journal Article] Phenotypic consequences in a Japanese family having branchio-oto-renal syndrome with a novel frameshift mutation in the gene EYA12007

    • Author(s)
      Matsunaga T, Okada M, Usami S, Okuyama T
    • Journal Title

      Acta Otolaryngol 127(1)

      Pages: 98-104

    • Peer Reviewed
  • [Journal Article] Application of Deafness Diagnostic Screening Panel Based on Deafness Mutation/Gene Database Using Invader Assay.2007

    • Author(s)
      Abe S, Yamaguchi T, Usami S
    • Journal Title

      Genetic Testing 11(3)

      Pages: 333-340

    • Peer Reviewed
  • [Journal Article] Mutations in the WFS1 gene are a frequent cause of autosomal dominant nonsyndromic low-frequency hearing loss in Japanese2007

    • Author(s)
      Fukuoka H, Kanda Y, Ohta S, Usami S
    • Journal Title

      J Hum Genet 52(6)

      Pages: 510-515

    • Peer Reviewed
  • [Journal Article] Immunocytochemical localization of ubiquitin A-52 protein in the mouse inner ear2007

    • Author(s)
      Kitoh R, Oshima A, Suzuki N, Hashimoto S, Takumi Y, Usami S
    • Journal Title

      Neuroreport 18(9)

      Pages: 869-873

    • Peer Reviewed
  • [Journal Article] Distribution and frequencies of CDH23 mutations in Japanese patients with non-syndromic hearing loss2007

    • Author(s)
      Wagatsuma M, Kitoh R, Suzuki H, Fukuoka H, Takumi Y, Usami S
    • Journal Title

      Clin Genet 72(4)

      Pages: 339-44

    • Peer Reviewed
  • [Journal Article] CRYM mutations cause deafness through thyroid hormone binding properties in the fibrocytes of the cochlea2006

    • Author(s)
      Oshima A, Suzuki S, Takumi Y, Hashizume K, Abe S, Usami S
    • Journal Title

      J Med Genet 43(6)

      Pages: 25

    • Peer Reviewed
  • [Journal Article] Association of SLC26A4 mutations with clinical features and thyroid function in deaf infants with enlarged vestibular aqueduct2006

    • Author(s)
      Iwasaki S, Tsukamoto K, Usami S, Misawa K, Mizuta K, Mineta H
    • Journal Title

      J Hum Genet 51(9)

      Pages: 805-10

    • Peer Reviewed
  • [Journal Article] A new autosomal recessive form of Stickler syndrome is caused by a mutation in the COL9A1 gene2006

    • Author(s)
      Van Camp G, Snoeckx RL, Hilgert N, van den Ende J, Fukuoka H, Wagatsuma M, Suzuki H, Smets RM, Vanhoenacker F, Declau F, Van de Heyning P, Usami S
    • Journal Title

      Am J Hum Genet 79(3)

      Pages: 449-57

    • Peer Reviewed
  • [Journal Article] Clinical course of hearing and language development in GJB2 and non-GJB2 deafness following habilitation with hearing aids2005

    • Author(s)
      Matsunaga T, Hirota E, Bito S, Niimi S, Usami S
    • Journal Title

      Audiol Neurootol 11(1)

      Pages: 59-68

    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of endolymphatic hydrops by bilateral intratympanic Gd-DTPA administration with MRI imaging for Meniere's disease

    • Author(s)
      Fukuoka H, Tsukada K, Miyagawa M, Oguchi T, Takumi1 Y, Sugiura M, Ueda H, Kadoya M, Usami S
    • Journal Title

      Acta Otolaryngol (in press)

    • Peer Reviewed
  • [Journal Article] Endolymphatic hydrops and therapeutic effects are visualized in "atypical" Meniere's disease

    • Author(s)
      Miyagawa M, Fukuoka H, Tsukada K, Oguchi1 T, Takumi Y, Sugiura M, Ueda H, Kadoya M, Usami S
    • Journal Title

      Acta Otolaryngol (in press)

    • Peer Reviewed
  • [Journal Article] Factors that affect hearing level in individuals with the mitochondrial 1555A>G mutation Clinic

    • Author(s)
      Ro SY, Nishio S, Tsukada K, Oguchi T, Kobayashi K, Abe S, Usami S
    • Journal Title

      Gent. 2008 (in press)

    • Peer Reviewed
  • [Presentation] SNP frequency in COCH is involved in Age-Related Hearing Impairment in aged Japanese2009

    • Author(s)
      Hashimoto S, Shinshu University Gene Research Consortium, NPO JTR, Nishio S, Takumi Y, Usami S
    • Organizer
      第3回運動・遺伝子・予防医療国際シンポジウム
    • Place of Presentation
      松本
    • Year and Date
      2009-03-16
  • [Presentation] Shinshu University Gene Research Consortium, NPO JTR, Nishio S, Takumi Y, Usami S, SNP frequency in COCH is involved in Age-Related Hearing Impairment in aged Japanese2009

    • Author(s)
      Hashimoto S
    • Organizer
      第2回運動・遺伝子・予防医療国際シンポジウム
    • Place of Presentation
      松本
    • Year and Date
      2009-03-11
  • [Presentation] 老人性難聴における遺伝的素因の検討 : セカンドコホートでの解析およびプロモーター領域の検討2008

    • Author(s)
      橋本繁成, 鈴木伸嘉, 工穣, 宇佐美真一
    • Organizer
      第回18日本耳科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-18
  • [Presentation] 老人性難聴における遺伝的因子の関与について-老人性難聴候補遺伝子のSNP遺伝子型と聴力との相関解析-2007

    • Author(s)
      橋本繁成, 鈴木伸嘉, 工穣, 宇佐美真一
    • Organizer
      第17回日本耳科学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-10-19
  • [Presentation] SAM の内耳における遺伝子発現について2007

    • Author(s)
      鈴木伸嘉, 橋本繁成, 工穣, 宇佐美真一
    • Organizer
      第17回日本耳科学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-10-18
  • [Presentation] SAMの内耳における遺伝子発現について2007

    • Author(s)
      鈴木伸嘉, 橋本繁成, 工穣, 宇佐美真一
    • Organizer
      第22回老化促進モデルマウス(SAM)研究協議会
    • Place of Presentation
      山形
    • Year and Date
      2007-07-26
  • [Presentation] Gene expression profiles in the cochlea of the senescence-accelerated mouse (SAM)2007

    • Author(s)
      鈴木伸嘉, 橋本繁成, 工穣, 宇佐美真一
    • Organizer
      国際老人性難聴会議
    • Place of Presentation
      ベルギー
    • Year and Date
      2007-05-25
  • [Presentation] SNP frequency in COCH is involved in Age-Related Hearing Impairment in aged Japanese2007

    • Author(s)
      橋本繁成, 鈴木伸嘉, 工穣, 宇佐美真一
    • Organizer
      国際老人性難聴会議
    • Place of Presentation
      ベルギー
    • Year and Date
      2007-05-23
  • [Remarks] 市民公開講座宇佐美真一, 耳の日市民公開講座「老人性難聴研究の進歩」, 2008.3.1, 長野

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Published: 2010-06-10   Modified: 2016-04-21  

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