Newly developed bio-active implant by minute control of apatite coating layer.

2008 Fiscal Year Final Research Report

• Project/Area Number: 17390516
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 補綴理工系歯学
• Research Institution: Okayama University
• Principal Investigator: MAEKAWA Kenji Okayama University, 医学部・歯学部附属病院, 講師 (20304313)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Yasuhiro 岡山大学, 大学院医歯薬学総合研究科, 准教授 (90281162) ; KUBOKI Takuo 岡山大学, 大学院医歯薬学総合研究科, 教授 (00225195)
• Project Period (FY): 2005 – 2008
• Keywords: チタン / インプラント / 表面改質 / 骨伝導性 / 酸化膜 / アパタイト / ポリリン酸

Research Abstract

失われた歯を補う目的で顎の骨に埋入されるチタンインプラントが,早期に確実に骨と結合して治療期間が短縮できるよう,チタン表面に生物学的な表面の改質を施した.具体的には,生体内に埋入された時に骨と親和性の高いアパタイトがチタン表面に自己形成される酸化膜を施し,骨の形成能が亢進される表面を開発した。また,ポリリン酸をチタン表面に吸着させることにより,高い生体活性を有するチタンインプラントの開発に繋がる可能性を示した。

Research Products

• [Journal Article] Effect of polyphosphoric-acid pre-treatment of titanium on attachment, proliferation and differentiation of osteoblast like cells (MC3T3-E1) (2008)
  • Author(s): Maekawa K, Yoshida Y, Mine A, Van Meerbeek B, Suzuki K, Kuboki T
  • Journal Title: Clin Oral Imp Res 19 Pages: 320-325
  • Peer Reviewed
• [Journal Article] Chemical interaction of polyphosphoric acid with titanium and its effect on human bone marrow derived mesenchymal stem cell behavior (2007)
  • Author(s): Maekawa K, Yoshida Y, Mine A, Fujisawa T, Van Meerbeek B, Suzuki K, Kuboki T
  • Journal Title: J Biomed Mater Res A 82 Pages: 195-200
  • Peer Reviewed
• [Journal Article] ポリリン酸処理によるチタン0.05無処理チタンセンサー無処理チタンセンサーインプラントへの細胞応答促進と成長因子吸着制御 (2006)
  • Author(s): 前川賢治
  • Journal Title: The Journal of Dental Engineering 156 Pages: 35-36
• [Journal Article] Polyphosphoric acid treatment promotes bone formation around titanium implants
  • Author(s): Maekawa K, Shimono K, Oshima M, Yoshida Y, Van Meerbeek B, Suzuki K, Kuboki T
  • Journal Title: Oral Rehabil (in press) Pages: 0
  • Peer Reviewed
• [Presentation] ポリリン酸を用いたチタンインプラントの生物学的表面改質 (2008)
  • Author(s): 前川賢治,下野賢吾,大島正充,峯 篤史,吉田靖弘,鈴木一臣,窪木拓男
  • Organizer: 第38回(社)日本口腔インプラント学会・学術大会
  • Place of Presentation: 東京
  • Year and Date: 20080913-14
• [Presentation] Effect of CH-treatment of titanium on bone formation around implants (2008)
  • Author(s): K. Maekawa, K. Kawanishi, S. Hayakawa, M. Oshika, K. Shimono, Y. Yoshida, K. Suzuki, A. Osaka, T. Kuboki
  • Organizer: 86^<th> General Session and Exhibition of the International Association for Dental Research
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20080702-05
• [Presentation] Chemical, mechanical, and biological properties of titanium implant surface treated with polyphosphoric acid (2007)
  • Author(s): K. Maekawa, Y. Yoshida, I. Hirata, M. Okazaki, K. Suzuki, T. Kuboki
  • Organizer: International Dental Materials Congress 2007
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 20071121-24
• [Presentation] Surface treatment with polyphos- phoric acid promotes osteogenesis around titanium implants (2007)
  • Author(s): K. Maeakwa, K. Shimono, M. Oshima, Y. Yoshida, K. Suzuki, T. Kuboki
  • Organizer: 85^<th> General Session and Exhibition of the International Association for Dental Research
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20070321-24
• [Presentation] ポリリン酸処理によるチタンインプラントの細胞応答促進と成長因子吸着制御 (2006)
  • Author(s): 前川賢治,吉田靖弘,峯 篤史,大島正充,下野賢吾,秋山謙太郎,藤澤拓生,鈴木一臣,窪木拓男
  • Organizer: 社団法人日本補綴歯科学会第115回学術大会
  • Place of Presentation: 札幌
  • Year and Date: 20060708-09
• [Presentation] Ti-surface modification using polyphosphoric acid enhanced osteoblast proliferation and bFGF adsorption (2006)
  • Author(s): K. Maekawa, A. Mine, I. Hirata, Y. Yoshida, M. Okazaki, K. Suzuki, T. Kuboki
  • Organizer: 35^<th> American Association for Dental Research
  • Place of Presentation: Orlando, USA
  • Year and Date: 20060308-11
• [Presentation] Titanium surface modification by polyphos- phoric acid accelerated mouse osteoblast like cell behavior (2006)
  • Author(s): K. Maekawa, Y. Yoshida, A. Mine, K. Akiyama, M. Ohshima, T. Fujisawa, K. Suzuki, T. Kuboki
  • Organizer: 2006 Spring Scientific Meeting of the Korean Academy of Prosthodontics: The 3rd International Joint Meeting with Japanese Prosthodontic Society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2006-04-28
• [Presentation] Acceleration of cell behavior and growth factor adsorption onto titanium implant surface by polyphosphoric acid treatment (2005)
  • Author(s): K. Maekawa, Y. Yoshida, I. Hirata, A. Mine, T. Fujisawa, M. Okazaki, K. Suzuki, T. Kuboki
  • Organizer: The 1^<st> Congress of Asian Academy of Osseointegration
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20051015-16
• [Patent(Industrial Property Rights)] Implant made with titanium or titanium alloy and surface treating method thereof (2008)
  • Inventor(s): Kuboki T, Maekawa K, Yoshida Y, Mine A, Fujisawa T, Van Meerbeek Bart, Kaneko T
  • Industrial Property Rights Holder: Kuboki T, Maekawa K, Yoshida Y, Mine A, Fujisawa T, Van Meerbeek Bart, Kaneko T
  • Acquisition Date: 2008-08-13