2007 Fiscal Year Final Research Report Summary
Research for improvement of prevention and treatment of HIV/AIDS among women and children in Africa
| Project/Area Number |
17406022
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Public health/Health science
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| Research Institution | Waseda University (2006-2007)
Research Institute, International Medical Center of Japan (2005) |
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Principal Investigator |
WAKASUGI Naomi Waseda University, Graduate School of Political Science, Professor (20118459)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Infectious Diseases / Virus / International Cooperation |
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| Research Abstract |
The diagnosis and antiretroviral treatment of child AIDS in Cote d'Ivoire.
【Background】
The coverage of Prevention of Mother to Child Transmission of HIV(PMTCT) to HIV-infected pregnant women in the world is only 9%.
Worldwide, 2,300,000 children are infected with HIV among which 780,000 children need antiretroviral therapy(ART) immediately. However less than 10% receive ART.
【Methods】
The diagnosis of HIV infection, AIDS stage, CD4%, ART regimen and the clinical effect of ART were investigated for children born to HIV infected mother(PMTCT cases) or who have AIDS sick family or are sick themselves(Sick cases). The study has been performed at 18 hospitals or clinics in Cote dIvoire from July 2004 to June 2006.
【Results】
Among 3365 children(0-13 years old) enrolled in this study 2476 children(73%) were found HIV positive. PMTCT cases were 32%(median age : 4months) and sick cases were 68% (median age : 6years). According to WHO guideline ART has been started for 1042 children with drug regimens AZT or d4T + 3TC + EFV or NVP. The regimen had to be changed after 1-4 months in 10% of children mainly due to side effects. The 12-month probability of survival on ART were 0.6 and 0.89 in children ART-naives with baseline CD4< ; 10% and 15-20%, respectively(p=0.003). The mean increase of CD4, body mass index and hemoglobin were +11 %(4.2-16), +1.3(0.1-2.6) and +1.4g/L(1.0-2.4), respectively
【 Discussion】
Our results showing satisfactory clinical improvement with ART given to AIDS children in Cote dIvoire suggest that ART for AIDS children is feasible even in Africa and similarly effective as in developed countries.
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