2007 Fiscal Year Final Research Report Summary
Higy- resolution MRI-aided analysis of cortical circuit in monkey brains
| Project/Area Number |
17500202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | National Center of Neurology and Psychiatry (2006-2007)
The University of Tokyo (2005) |
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Principal Investigator |
NAKAHARA Kiyoshi National Center of Neurology and Psychiatry, NCNP, Institute of Neuroscience, Section Chief (50372363)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Cerebral Cortex / Neuronal Circuit / Magentic Resonance Imaging / Microelectrode Recording |
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| Research Abstract |
The localization of microelectrode recording sites in the layers of primate cerebral cortex permits the analysis of relationships between recorded neuronal activities and underlying anatomical connections. We have developed a magnetic resonance imaging method for precise in vivo localization of cortical recording sites. In this method, the susceptibility-induced effect thickens the appearance of the microelectrode and enhances the detectability of the microelectrode tip, which usually occupies less than a few percent of the volume of an image voxel. In a phantom study, the optimized susceptibility-induced effect allowed tip detection with single-voxel accuracy. We applied this method to recording microelectrodes inserted into the brains of macaque monkeys, and localized the microelectrode tip at an in-plane resolution of 150 um within the cortex of 2-3 mm in thickness. Subsequent histological analysis validated the single-voxel accuracy of the in vivo tip localization. This method opens up a way to investigate information flow during cognitive processes in the brain.
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