2006 Fiscal Year Final Research Report Summary
Evolutional analysis of multicellularization in relation to STAT signals by use of Dictyostelium.
| Project/Area Number |
17570190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Toho University |
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Principal Investigator |
KAWATA Takefumi Faculty of Science, Associate Professor, 理学部, 助教授 (30221899)
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| Project Period (FY) |
2005 – 2006
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| Keywords | genes / signal transduction / evolution / development ＆ differentiation |
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| Research Abstract |
1. We isolated 12 novel STATa suppressor genes by genetical screening.
2. A segment of dutA gene was a suppressor of STATa. We proved endogenous dutA is negatively regulating STATa activity through tyrosine phosphorylation to prevent culmination. Overexpressed dutA segment was acting dominant negative fashion to inhibit endogenous dutA to promote culmination. There was an increased tyrosine phosphrylation of partially active STATa in the suppressed clones (Shimada and Kawata, 2007).
3. We are characterizing two more suppressor genes, NK20 and sunB.
4. We isolated genes supposed to be involved in programmed cell death and are regulated their expressions by STATa. We isolated one of null mutant and are characterizing it.
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