2006 Fiscal Year Final Research Report Summary
Bioorganic Study on Mycoparasitism on Apple Fruit
| Project/Area Number |
17580090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
HASHIMOTO Masaru Hirosaki University, Faculty of Agriculture and Life science, Professor, 農学生命科学部, 教授 (40212138)
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| Project Period (FY) |
2005 – 2006
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| Keywords | mycoparasitism / Lambertella sp. 1346 / Monilinia fructigena / lambertellol / mechanism / responsible substances / acidity of media / culturing conditions |
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| Research Abstract |
The filamentous fungus, Lambertella corni-maris and Lambertella sp. 1346 develop a mycoparasitism on apple fruit against another fungus Monilinia fructigena. Since Lambertella sp.1346 produces lambertellols in substantial amounts and these metabolites induced remarkable antifungal activity against the host Monilinia fructigena, these were expected to be responsible substances for mycoparasitism. On the other hand, Lambertella corni-maris produces these antibiotics but in only a trace of amount under the same conditions employed for Lambertella sp.1346. We found Lambertella corni-maris also provides these antibiotics under acidic conditions. Our investigation also revealed that the host, Monilinia fructigena, changed its surroundings into acidic conditions, suggesting that the acidic conditions acted as kiromons that simulated the productions of them.
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[Journal Article] An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer2006
Author(s)
Hashimoto, M., Murakami, T., Funahashi, K., Tokunaga, T., Nihei, K., Okuno, T., Kimura, T., Naoki, H., Himeno, H
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Journal Title
Bioorg. Med. Chem 14
Pages: 8259-8270
Description
「研究成果報告書概要(和文)」より
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[Journal Article] An RNA polymerase inhibitor, cyclothiazomycin Bl, and its isomer2006
Author(s)
Hashimoto, M., Murakami, T., Funahashi, K., Tokunaga, T., Nihei, K., Okuno, T., Kimura, T., Naoki, H., Himeno, H.
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Journal Title
Bioorg.Med.Chem 14
Pages: 8259-8270
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Design, synthesis, and enzymatic property of a sulfur-substituted analogueof trigalacturonic acid2005
Author(s)
Yamamoto, K., Watanabe, N., Matsuda, H., Oohara, K., Araya, T., Hashimoto, M., Miyairi, K., Okazaki, I., Saito, M., Shimizu, T., Kato, H., Okuno, T.
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Journal Title
Bioorg. Med. Chem, Lett. 15
Pages: 4932-4935
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Synthetic studies on oligosaccharides composed of 5-thioglucopyranose units2005
Author(s)
Morii, Y., Matsuda, Y., Ohara, K., Hashimoto, M., Miyairi, K., Okuno, T.
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Journal Title
Bioorg. Med. Chem. 13
Pages: 5113-5144
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Design, synthesis, and enzymatic property of a sulfur-substituted analogue of trigalacturonic acid2005
Author(s)
Yamamoto, K., Watanabe, N., Matsuda, H., Oohara, K., Araya, T., Hashimoto, M., Miyairi, K., Okazaki, I., Saito, M., Shimizu, T., Kato, H., Okuno, T.
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Journal Title
Bioorg.Med.Chem, Lett. 15,22
Pages: 4932-4935
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Synthetic studies on oligosaccharides composed of 5-thioglucopvranose units2005
Author(s)
Morii, Y., Matsuda, Y., Ohara, K., Hashimoto, M., Miyairi, K., Okuno, T.
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Journal Title
Bioorg.Med.Chem. 13
Pages: 5113-5144
Description
「研究成果報告書概要(欧文)」より
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