2006 Fiscal Year Final Research Report Summary
Effects ofresistantproleins oflivestock, bovine Achilles' tendons and arteries, on lipidmettholism in rats.
| Project/Area Number |
17580100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Obihiro University ofAgriculture and Veterinary Medicine, Faculty ofAnimal Husbandry |
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Principal Investigator |
FUKUSHIMA Michihiro Obihiro University of Agricukne and Veterinary Medicine, Department of Agricultural and Life Science, Professor, 畜産学部, 教授 (20231558)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Ken-ichiro Obihiro University of Agricuiture and Veterinay Medicine, Department of Food and Production Science, Assistant Professor, 畜産学部, 助教授 (80301969)
SENBOKUYA Yasushi Obihiro University of Agricuburc and Veterinary Medicine, Department of Food and Production Science, Assistant Professor, 畜産学部, 助教授 (50243382)
SEKIKAWA Mitsuo Obihiro University of Agricuiture and Veterinary Medicine, Graduate School of Animal and Food Hygiene, Professor, 大学院畜産学研究科, 教授 (30120489)
HIDAKA Satoshi Obihiro University of Agriculture and Veterinary Medicine, Department of Food and Production Science, Professor, 畜産学部, 教授 (30133804)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Animal protein / Bovine Achilles' tendons / Bovine arteries / Rat / Cholesterol / Triglyceride / Intestinal anaerobe / Intestinal Bifidobacterium |
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| Research Abstract |
We examined the physiological importance of bovine dietary proteins in rats fed diets prepared from bovine Achilles' tendons and arteries. Rats were fed a cholesterol-free diet with 20% casein diet (CON), in comparison with two diets containing 15% casein and 5% of either bovine Achilles' tendons (AC) or arteries (AR) protein preparations for 4 weeks. The serum total cholesterol concentration and non-HDL cholesterol level in the AR fed group were significantly lower (P<0.05) than those in the CON group at the end of the 4 week feeding period. The hepatic mRNAs were measured, and the HMG-CoA reductase mRNA level was significantly lower (P<0.05) in AR fed group compared to CON group, and that in AC fed group tended to be lower compared to CON group. Total hepatic cholesterol concentration, in rats fed AC was significantly (P<0.05) higher than in the CON group. The serum triglyceride (TG) concentration and fatty acid synthase (FAS) mRNA level in AC and AR fed groups were significantly lower (P<0.05) compared to the CON group through out the feeding period. Faecal neutral sterol excretion was significantly (P<0.05) higher in the AC and AR fed groups compared to the CON group. The results of this study demonstrate that the some bovine dietary proteins have similar functions as dietary fibres which lowered the serum lipid concentration by enhancing faecal neutral sterol excretion, and suppressing lipid synthesis in the liver. Moreover, favourable amino acid compositions in AR and AC may also have an effect on low plasma lipid concentration in bovine protein diets fed groups.
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