2007 Fiscal Year Final Research Report Summary
Regulation of adipocytes differentiation by marine lipids
| Project/Area Number |
17580178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
HOSOKAWA Masashi Hokkaido University, Faculty of Fisheries Sciences, Associate Professor (10241374)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Adipocyte / Anti-obesity effect / Differentiation / Fucoxanthin / DHA / EPA |
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| Research Abstract |
Obesity is now recognized as a world wide problem. It is multiple risk factors for the life style-related diseases such as diabetes, hypertension, hyperlipidemia, and cardiovascular disease. Visceral fat accumulation plays crucial roles in the development of these diseases. So, it is important to prevent the life style-related diseases through significantly reducing excess accumulation of visceral fat. Fucoxanthin is a major carotenoid found in edible seaweed such as Undaria pinnatifida and Hijikia fusiformis. Fucoxanthin and its metabolite, fucoxanthinol, inhibited intercellular lipid accumulation and suppressed glycerol-3-phosphate dehydrogenase activity during adipocyte differentiation of 3T3-L1 cells. In addition, in 3T3-L1 cells treated with fucoxanthin and fucoxanthinol, peroxisome proliferators-activated receptor (PPAR_γ), which regulates adipogenic gene expression, was down-regulated in a dose-dependent manner. N-3 Highly unsaturated fatty acid, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are major fatty acids in fish oil, also suppressed adipocyte differentiation of 3T3-L1 cells by down regulation PPAR_γ And C/EBP_α. White adipose tissue weight of mice fed fucoxanthin was significantly lower than that of mice fed control diet. Uncoupling protein 1(UCP1), a key molecule for metabolic thermogenesis, was clearly found in WAT of mice fed fucoxanthin. The anti-obesity effect of fucoxanthin was enhanced by the combination with fish oil containing DHA and EPA
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