2006 Fiscal Year Final Research Report Summary

Development of New and Efficient Organic Transformations Catalyzed by Molybdenum

Research Project

Project/Area Number	17590021
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Chemical pharmacy
Research Institution	Nigata University of Phermacy and Applied Life Sciences
Principal Investigator	SUGIHARA Takumichi Nigata University of Phermacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Professor (40222054)
Project Period (FY)	2005 – 2006
Keywords	molybdenum / catalyst / n-ligand / propargyl bromide / allyl substitution / cvclization
Research Abstract	We developed a new catalyst based on molybdenum, which was made in situ by reaction of molybdenum hexacarbonyl with Propargyl bromide. The catalyst promoted [2+2+2]-cocyclization of diynes having both terminal alkynes with propargyl bromide to produce substituted benzyl bromide derivatives. When diynes had both terminal and internal alkynes, the reaction with propargyl bromide produced cyclized bromodiene derivative without incorporation of alkyne part of propargyl bromide. In addition, reaction of allenylmethyl acetate with propargyl bromide catalyzed by n-propargylmolubdenum gave 2-bromo-1,3-butadiene derivatives. The scope and limitation of these reactions was also investigated. Since no other transition metal complexes mediated these reactions, our findings should be inherent organic transformations of molybdenum.