2007 Fiscal Year Final Research Report Summary
Synthetic Study of Neovibsanins and Furanovibsanins
| Project/Area Number |
17590027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
IMAGAWA Hiroshi Tokushima Bunri University, Faculty of Pharmaceutical Sciences, Associate professor (80279116)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Neovibsanin / Neurodegenerative disease / Alzheimer disease / Intramolecular Diels-Alder reaction / PC12 cell |
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| Research Abstract |
Neobivsanin A, a novel tricyclic bistetrahydrofuran isolated from Viburnum awabuki, have been proved to have show neurite-outgrowth enhancing activity of neurite-outgrowth effect by NGF for PC12 cell by Fukuyama, et. al., and The compound is promising as this could be a seed compound to develop of therapeutic agent for neurodegenerative disease such as Alzheimer disease. Therefore, we launched synthetic study of neovibsanin A and its derivatives. As the result, we achieved synthesis of 4-epi-5-epi-neobivsanin A based on DMI accelerated intramolecular Diels-Alder reaction and oxy-Michael additon-lactonization reaction as key steps. Furthermore, syntheses of a number of derivatives were accomplished, and the structure activity rcorrelationselashonships were revealed established by collaborative research with Fukuyama's group. As the results, it was revealed that the compounds have the neurite-outgrowth enhancing activity against PC12 cells.
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[Presentation] ネオビブサニン類の合成研究2007
Author(s)
栗崎 貴啓, 今川 洋, 西沢 麦夫
Organizer
日本薬学会第127春期年会
Place of Presentation
富山
Year and Date
20070327-30
Description
「研究成果報告書概要(和文)」より
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[Presentation] ネオビブサニン類の合成研究2007
Author(s)
今川 洋, 栗崎 貴啓, 西條 速人, 山本 博文, 難波 康祐, 西沢 麦夫, 緒方 美津子, 高橋 宏暢, 福山 愛保
Organizer
第4回継続オープンリサーチセンター研究発表会
Place of Presentation
徳島
Year and Date
2007-12-15
Description
「研究成果報告書概要(和文)」より
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