2006 Fiscal Year Final Research Report Summary
Functional analysis of DJ-1, a causative gene product for familial Parkinson's disease
| Project/Area Number |
17590049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Yamanashi |
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Principal Investigator |
TAIRA Takahiro University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Professor, 大学院医学工学総合研究部, 教授 (70197036)
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| Project Period (FY) |
2005 – 2006
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| Keywords | DJ-1 / Parkinson's disease / Oxidative stress / reactive oxygen species / 病態モデル |
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| Research Abstract |
DJ-1 has recently been shown to be responsible for onset of familial Parkinson's disease (PD), PARK7. DJ-1 has been shown to play roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to trigger onset of PD. In this study, a recombinant DJ-1 protein was administrated into the brain of PD model rats that had been injected to 6-hydroxydopamine (6-OHDA) in the left substantia nigra. PD phenotypes, including dopaminergic neuron death both in the substantia nigra and striatum, decrease in dopamine and dopamine transporter levels in the striatum, and motor abnormality, were dramatically improved by wild-type DJ-1 but not L166P DJ-1, a mutant form of DJ-1 found in PD patients. Furthermore, production of reactive oxygen species and cell death induced by 6-OHDA in SH-SY5Y cells were inhibited by addition of the recombinant DJ-1. These findings suggest that DJ-1 is a therapeutic target for PD.
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[Journal Article] DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy.2007
Author(s)
Koide-Yoshida, S., Niki, T., Ueda, M., Himeno, S., Taira, T., Iguchi-Ariga, S.M.M., Ando, Y., Ariga, H.
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Journal Title
Int. J. Mol. Med. 19
Pages: 885-893
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.2007
Author(s)
Inden, M., Kitamura, Y., Takeuchi, H., Yanagida, T., Takata, K., Kobayashi, Y., Taniguchi, T., Yoshimoto, K., Kaneko, M., Okuma, Y., Taira, T., Ariga, H., Shimohama, S.
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[Journal Article] Distribution of DJ-1, Parkinson's disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain.2006
Author(s)
Yanagida, T., Takada, K., Inden, M., Kitamura, Y., Taniguchi, T., Yoshimoto, K., Taira, T., Ariga, H.
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Journal Title
J. Pharmacol. Sci. 102
Pages: 243-247
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model.2006
Author(s)
Inden, M., Taira, T., Kitamura, Y., Yanagida, T., Tsuchiya, D., Takata, K., Yanagisawa, D., Nishimura, K., Taniguchi, T., Kiso, Y., Yoshimoto, Y., Wagatsuma, T., Koide-Yoshida, S., Iguchi-Ariga, S.M.M., Shimohama, S., Ariga, H.
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Journal Title
Neurobiol. Dis. 24
Pages: 144-158
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] DJ-1 interacts with HIPK1 and affects H202-induced cell death.2006
Author(s)
Sekito, A., Koide-Yoshida, S., Niki, T., Taira, T., Iguchi-Ariga, S.M.M., Ariga, H.
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Journal Title
Free Radic. Res. 40
Pages: 155-165
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Distinct Localizations and Repression Activities of MM-1 Isoforms toward c-Myc2006
Author(s)
Hagio, Y., Kimura, Y., Taira, T., Fujioka, Y., Iguchi-Ariga, S.M.M., Ariga, H.
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Journal Title
J. Cell. Biochem. 97
Pages: 145-155
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities.2006
Author(s)
Shinbo, Y., Niki, T., Taira, T., Ooe, H., Takahashi-Niki, K., Maita, C Seino, C., Iguchi-Ariga, S.M.M., Ariga, H.
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Journal Title
Cell Death Diff. 13
Pages: 96-108
Description
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[Journal Article] Expression profiles of genes in DJ-1-knockdown and L166P DJ-1 mutant cells.2005
Author(s)
Nishinaga, H., Takahashi-Niki, K., Taira, T., Andreadis, A., Iguchi-Ariga, S.M.M., Ariga, H.
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Journal Title
Neuroscience Lett. 390
Pages: 54-59
Description
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