• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2008 Fiscal Year Final Research Report

Oxidative degeneration of neurodegenerative disease-related protein and reactive nitrogen oxide stress

Research Project

  • PDF
Project/Area Number 17590089
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionNagoya City University

Principal Investigator

NAKAGAWA Hidehiko  Nagoya City University, 大学院・薬学研究科, 准教授 (80281674)

Co-Investigator(Renkei-kenkyūsha) MIYATA Naoki  名古屋市立大学, 大学院・薬学研究科, 教授 (50114674)
SUZUKI Takayoshi  名古屋市立大学, 大学院・薬学研究科, 講師 (90372838)
Project Period (FY) 2005 – 2008
Keywords酸化ストレス / 有機化学 / 一酸化窒素 / パーオキシナイトライト / ドナー化合物 / 化学プローブ
Research Abstract

αシヌクレインの凝集体生成に対する酸化ストレスの影響を試験管内反応で検討することでニトロ化修飾の影響を示唆し、またこの知見から、酸化ストレス検討に有用な化合物開発を行い、機能性光誘起型NO発生剤の開発、二光子励起光誘起型NO発生剤、ニトロ化選択的活性酸素消去剤の開発、および細胞内部位特異的酸化ストレス計測プローブの開発を行い、それぞれの目的の性能を発揮することを示した。

  • Research Products

    (12 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (4 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Photoactivatable HNO-releasing compounds using the retro-Diels-Alder reaction2008

    • Author(s)
      Yusuke Adachi, Hidehiko Nakagawa, Kazuya Matsuo, Takayoshi Suzuki, Naoki Miyata
    • Journal Title

      Chem. Commun

      Pages: 5149-5151

    • Peer Reviewed
  • [Journal Article] New Series of Antiprion Compounds : Pyrazolone Derivatives Have the Potent Activity of Inhibiting Protease-Resistant Prion Protein Accumulation2007

    • Author(s)
      Ayako Kimata, Hidehiko Nakagawa, Ryo Ohyama, Tomoko Fukuuchi, Shigeru Ohta, Takayoshi Suzuki, Naoki Miyata
    • Journal Title

      J. Med. Chem 50

      Pages: 5053-5056

    • Peer Reviewed
  • [Journal Article] Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria, Bioorg2007

    • Author(s)
      Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata
    • Journal Title

      Med. Chem. Lett 17

      Pages: 2055-2058

    • Peer Reviewed
  • [Journal Article] Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane2007

    • Author(s)
      Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata
    • Journal Title

      Bioorg. Med. Chem. Lett 17

      Pages: 1451-1454

    • Peer Reviewed
  • [Journal Article] Photoinduced Nitric Oxide Release from Nitrobenzene Derivatives2005

    • Author(s)
      Takayoshi Suzuki, Osamu Nagae, Yuka Kato, Hidehiko Nakagawa, Kiyoshi Fukuhara, Naoki Miyata
    • Journal Title

      J. Am. Chem. Soc 127

      Pages: 11720-11726

    • Peer Reviewed
  • [Journal Article] 2, 2, 6, 6-Tetramethylpiperidin-1-oxyl probes for evaluating oxidative stress on the cell membrane and mitochondria, Methods in Molecular Biology

    • Author(s)
      Hidehiko Nakagawa, Naoki Miyata
    • Journal Title

      477 : Advanced Protocols in Oxidative Stress I,(Edited by : D. Armstrong, Humana Press, New York, NY)(依頼)

      Pages: 99-112

  • [Presentation] 光で制御するNOおよびHNOドナー化合物2009

    • Author(s)
      中川秀彦
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2009-03-28
  • [Presentation] EPR Probes for Measuring Sub-cellular Oxidative Stress2007

    • Author(s)
      Hidehiko Nakagawa, Shizuka Ban, Takayoshi Suzuki, Naoki M iyata
    • Organizer
      the 4th Joint Meeting of the Society for Free Radical Research Australasia and Japan
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-12-03
  • [Presentation] 細胞内部位特異的酸化ストレス計測を目指したTEMPO 誘導体の開発2006

    • Author(s)
      中川秀彦
    • Organizer
      第45回電子スピンサイエンス学会年会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2006-11-14
  • [Presentation] ニトロベンゼン構造に基づく新規光誘起型NOドナーの開発2006

    • Author(s)
      中川秀彦, 鈴木孝禎, 加藤友香, 長江修, 福原潔, 宮田直樹
    • Organizer
      日本ケミカルバイオロジー研究会第1回年会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-08
  • [Book] 酸化ストレスの医学(吉川敏一監修, 内藤裕二, 豊国伸哉編, 診断と治療社, 東京)2008

    • Author(s)
      中川秀彦, 宮田直樹
    • Total Pages
      88-96
    • Publisher
      フリーラジカルの測定法
  • [Patent(Industrial Property Rights)] アシルニトロソ誘導体環化付加アントラセン誘導体及び光作動性HNO供与体2008

    • Inventor(s)
      宮田直樹、中川秀彦、松尾和哉、鈴木孝禎
    • Industrial Property Rights Holder
      名古屋市立大学
    • Industrial Property Number
      特願2008-284899
    • Filing Date
      2008-11-05

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi