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2006 Fiscal Year Final Research Report Summary

Central command-induced changes in regional cerebral blood flow during voluntary exercise and sleep in rats.

Research Project

Project/Area Number 17590203
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNara Women's University

Principal Investigator

MIKI Kenju  Nara Women's University, Graduate School of Humanities and Sciences, Professor, 大学院人間文化研究科, 教授 (80165985)

Project Period (FY) 2005 – 2006
KeywordsExercise / Arterial pressure / Sympathetic nerve activity / REM sleep / Rat
Research Abstract

CENTRAL COMMAND signals from the higher brain have been thought to converge with afferent signals arising from the working skeletal muscle to cause an overall cardiovascular response in proportion to the intensity of physical activity or perceived effort. It has been pointed out that central command and muscle afferent input, can act independently to elicit cardiovascular responses. However, role of central command during exercise has not been completely understood yet.
It would be worth to try to measure the higher brain nerve activity directly to elucidate the role of central command in animal. In the present study, we tried to measure the central command-induced changes in regional cerebral blood flow in the hippocampal CA1 area (CBFhippo), during grooming, moving, non-rapid eye movement sleep and rapid eye movement sleep.
We demonstrated clearly that rCBF of the hippocampus CA1 region increased significantly during REM sleep and moving. Since it has been suggested that memory consolidation occur during REM sleep, the increase in CBFhippo observed during REM sleep may possibly represent the time course of the central command that occurred when rats were awake.
We also try to directly measure hippocampal CA1 neuron activity in freely moving rats using micro-wire array in rats. We have succeeded in measuring CA1 neuron activity during quiet awake but not during moving and grooming because of contamination of external noise. It would be necessary to improve the detail method of micro-wire array and experimental procedures.

  • Research Products

    (20 results)

All 2007 2006 2005

All Journal Article (10 results) Book (10 results)

  • [Journal Article] Baroreflexes and Renal Function2007

    • Author(s)
      Miki, K., Yoshimoto, M
    • Journal Title

      J Gravitational Physiology (In press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 起立負荷に対する循環・体液調節応答2007

    • Author(s)
      三木健寿
    • Journal Title

      Journal of Clinical Rehabilitation 16

      Pages: 286-292

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 重力が循環・体液調節に及ぼす影響2007

    • Author(s)
      三木健寿
    • Journal Title

      Journal of Clinical Rehabilitation 16

      Pages: 171-177

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Baroreflexes and Renal Function2007

    • Author(s)
      Miki, K., Yoshimoto, M.
    • Journal Title

      J Gravitational Physiology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cardiovascular and renal adjustments to upright posture2007

    • Author(s)
      Miki, K.
    • Journal Title

      Journal of Clinical Rehabilitation 16

      Pages: 286-292

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effects of gravity on circulatory regulation2007

    • Author(s)
      Miki, K.
    • Journal Title

      Journal of Clinical Rehabilitation 16

      Pages: 171-177

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The contribution of brain angiotensin II to the baroreflex regulation of renal sympathetic nerve activity in conscious normotensive and hypertensive rats.2006

    • Author(s)
      Huang C, Yoshimoto M, Miki K, Johns EJ
    • Journal Title

      J Physiol (Lond) 574

      Pages: 597-604

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The contribution of brain angiotensin II to the baroreflex regulation of renal sympathetic nerve activity in conscious normotensive and hypertensive rats2006

    • Author(s)
      Huang C, Yoshimoto M, Miki K, Johns EJ
    • Journal Title

      J Physiol (Lond) 574

      Pages: 597-604

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differential effects of behaviour on renal and lumbar sympathetic outflow in conscious rats2005

    • Author(s)
      Miki K., Yoshimoto
    • Journal Title

      Experimental Physiology 90

      Pages: 155-158

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Differential effects of behaviour on renal and lumbar sympathetic outflow in conscious rats (Invited review)2005

    • Author(s)
      Miki K., Yoshimoto, Y.
    • Journal Title

      Exp Physiol. 90

      Pages: 155-158

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Sympathetic regulation of arterial pressure during daily activity In : Central Mechanisms of Cardiovascular Regulation (ed by Kuwaki)2007

    • Author(s)
      Miki, K., Yoshimoto, M
    • Publisher
      Research Signport, Kerala(In press)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] "睡眠と自律機能 : 循環器系と睡眠"「睡眠学」2007

    • Author(s)
      三木健寿
    • Publisher
      朝倉書店(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] "腎交感神経活動の慢性連続記録"「最新自律神経学」2007

    • Author(s)
      三木健寿
    • Total Pages
      417-422
    • Publisher
      新興医学出版社、東京
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Central Mechanisms of Cardiovascular Regulation ("Sympathetic regulation of arterial pressure during daily activity") (ed by Kuwaki)2007

    • Author(s)
      Miki, K., Yoshimoto, M.
    • Publisher
      Research Signport, Kerala (in press)
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Sleep ("Sleep and autonomic function : Cardiovascular regulation during sleep.")2007

    • Author(s)
      Miki, K.
    • Publisher
      Asakura Publishing, Tokyo (in press)
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Advanced Autonomic Sciences ("Chronic monitoring of renal sympathetic nerve activity.")2007

    • Author(s)
      Miki K.
    • Total Pages
      417-422
    • Publisher
      Shinko Publishing, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Acute shifts in baroreflex control of renal sympathetic nerve activity during exercise and sleep. In : Exercise, Nutrition, Environmental Stress2005

    • Author(s)
      Yoshimoto M., Miki K
    • Total Pages
      165-184
    • Publisher
      Cooper Publishing Group
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] "循環"「人体の構造と機能」2005

    • Author(s)
      三木健寿
    • Total Pages
      43-61
    • Publisher
      建帛社,東京
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Exercise, Nutrition, Environmental Stress, vol.4, Chapt.10 ("Acute shifts in baroreflex control of renal sympathetic nerve activity during exercise and sleep. ")2005

    • Author(s)
      Yoshimoto M., Miki K.
    • Total Pages
      165-184
    • Publisher
      Cooper Publishing Group, LLC
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Functions and Structures in Human. ("Circulation." )2005

    • Author(s)
      Miki K.
    • Total Pages
      43-61
    • Publisher
      Kenpaku-sha, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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