2006 Fiscal Year Final Research Report Summary
Effect of an alpha-lb adrenoceptor antagonist on methamphetamine-induced neuronal toxicity
| Project/Area Number |
17590228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Teikyo University |
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Principal Investigator |
NAKAKI Toshio Teikyo Univ., Pharmacology, Professor, 医学部, 教授 (30164148)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Nobuko Teikyo Univ., Pharmacology, Researcher, 医学部, 助手 (30317698)
UTSUMI Kazue Teikyo Univ., Pharmacology, Researcher, 医学部, 助手 (90271759)
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| Project Period (FY) |
2005 – 2006
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| Keywords | methamphetamine / prazosin / alpha-1 adrenoceptors / alpha-1b adrenoceptor / neurodegeneration / Parkinson's disease / 神経変性 / 実験室温度調節 |
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| Research Abstract |
A nonselective alpha-1 adrenoceptor antagonist prazosin protected methamphetamine-induced neuronal toxicity, while a selective alpha-lb adrenoceptor antagonist failed to do so. We conclude that the neuro-protective effect of prazosin is some unidentified mechanisms other than the alpha-lb receptor blockade.
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