2006 Fiscal Year Final Research Report Summary
The function of the Wilms' tumor gene (WT1) overexpressed in leukemia and solid cancers
| Project/Area Number |
17590266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
OJI Yusuke Osaka University, Dept.of Biomedical Informatics, Associate Professor, 医学系研究科, 助教授 (20294100)
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| Co-Investigator(Kenkyū-buntansha) |
OKA Yoshihiro Osaka University, Dept.of Molecular Medicine, Associate Professor, 医学系研究科, 講師 (20273691)
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| Project Period (FY) |
2005 – 2006
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| Keywords | WT1 / anti-apootosis / motility / leukemia / solid cancer |
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| Research Abstract |
The WT1 gene has four isoforms by alternative splicing at two sites [17AA(+)KTS(+),17AA(+)KTS(-),17AA(-)KTS(+),17AA(-)KTS(-)]. In the present project, we have demonstrated that WT1 17AA(+) isoforms [17AA(+)KTS(+),17AA(+)KTS(-)] played antiapoptotic roles in leukemia and various kinds of solid cancers and that WT1 17AA(-)KTS(-) isoform promoted cell motility and played antiapoptotic roles in solid cancers. Moreover, the studies using deletion mutants revealed several sites of the WT1 gene associated with its antiapoptotic function and enhancement of cell motility.
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