2007 Fiscal Year Final Research Report Summary
Regulatory role of phosphorylation of tumor suppressor Fhit protein
| Project/Area Number |
17590275
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
ISHII Hideshi Jichi Medical University, School of Medicine, Lecturer (10280736)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Keywords | Biochemistry / Tumor Suppressor Gene / Checkpoints / genomic / Lgenomic Instability / Cancer Stem Cells / FHIT |
|---|
| Research Abstract |
The fragile FHIT gene is among the first targets of DNA damage in preneoplastic lesions and recent studies have shown that Fhit protein is involved in surveillance of genome integrity and checkpoint response after genotoxin exposure. We studied that Fhit modulate the checkpoint response via regulation of phosphorylation at Y114 of Fhit protein. The response was regulated Atr kinase, and define the responsiveness of normal and cancer cells. Furthermore, Fhit-deficient hematopoietic cells, exposed to the genotoxin hydroquinone, are resistant to the suppression of stem cell in vitro colony formation observed with wild type hematopoietic cells. The present results indicate that reduced oxidative stress, coupled with efficient but error-prone DNA damage repair, allows unscheduled, long-term survival of genotoxin-exposed Fhit-deficient hematopoietic stem cells carrying deleterious mutations, suggesting the significance in the multistep carcinogenesis.
|
-
-
[Journal Article] Fez 1/Lzts 1 deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine(BBN) carcinogenesis2008
Author(s)
Baffa R, Fassan M, Sevignani C, Vecchione A, Isha H, Giarnieri E, Iozzo, RV, Gomella, LG, Croce, CM
-
Journal Title
Carcinogenesis (in press)
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes2008
Author(s)
Ishii, H., Mimori, K., Ishikawa, K., Okumura, H., Pichiorri, F., Druck, T., Inoue, H., Vecchione, A., Saito, T., Mori, M., Huebner, K
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Clinical significance of the reduced expression of G protein gamma 7(GNG7) in esophageal cancer2008
Author(s)
Ohta, M., Mimori, K., Fukuyoshi, Y., Kita, Y., Motoyama, K., Yamashita, K., Ishii, H., Inoue, H., Mori, M
-
Journal Title
Br. J. Cancer 98
Pages: 410-7
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Journal Article] Rad9 modulates the P21WAF1 pathway by direct association with p532007
Author(s)
Ishikawa K, Ishii H, Murakumo Y, Mimori K, Kobayashi M, Yamamoto, KI, Mori M, Nishino H, Furukawa Y, Ichimura, K
-
Journal Title
BMC Mol. Biol 8(1)
Pages: 37
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Fezl/Lztsl absence impairs Cdkl/Cdc25C interaction during mitosis and predisposes to cancer development2007
Author(s)
Vecchione, A., Bladassarre, G., Ishii, H., Belletti, B., Nicoloso, M.S., Fong, LY.Y., Zanesi, N., Petrocca, F., Fidanza, V., Alder, H., Donovan, P.J., Baffa, R., Croce, C.M
-
Journal Title
Cancer Cell 11
Pages: 275-289
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
[Journal Article] Loss of MAL expression in precancerous lesions of the esophagus2006
Author(s)
Mimori, K., Nishida, K., Nakamura, Y., Ieta, K., Yoshikawa, Y., Sasaki, A., Ishii, H., Alonso, M.A., Mori, M
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Fhit Modulates the DNA Damage Checkpoint Response2006
Author(s)
Ishii., H., Mimori, K., Inoue, H., Inageta, T., Ishikawa, K., Semba, S., Druck, T., Trapasso, F., Tani, K., Vecchione, A., Croce, C.M., Mori, M., Huebner, K
-
Journal Title
Cancer Res 66
Pages: 11287-92
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression2006
Author(s)
Mimori, K., Ishii, H., Nagahara, H., Sudo, T., Yamashita, K., Inoue, H., Barnard, G.F., Mori, M
-
Journal Title
Cancer Res 66
Pages: 2683-90
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Fhit modulation of the Akt-survivin pathway in lung cancer cells : Fhit-tyrosine 114(Y114) is essential2006
Author(s)
Semba, S., Trapasso, F., Fabbri, M., McCorkell, K.A., Volinia, S., Druck, T., Iliopoulos, D., Pekarsky, Y., Ishii. H., Garrison, P.N., Barnes, LD., Croce, C.M., Huebner, K
-
Journal Title
Oncogene 25
Pages: 2860-72
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Histone deacetylase inhibitor depsipeptide(FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib2006
Author(s)
Sutheesophon, K., Kobayashi, Y., Takatoku, M.A., Ozawa, K., Kano, Y., Ishii E, Furukawa, Y
-
Journal Title
Acta Haematol 115
Pages: 78-90
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers2006
Author(s)
Mimori, K., Nagahara, H., Sudo, T., Jshii, H., Yamashita, K., Barnard, G.F., Mori, M
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
[Journal Article] a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis2005
Author(s)
Ishii., H., Inageta, T., Mimori, K., Saito, T., Sasaki, H., Isobe, M., Mori, M., Croce, C.M., Huebner, K., Ozawa, K. Furukawa, F., Fragl
-
Journal Title
Proc. Natl. Acad. Sci. USA 102
Pages: 9655-60
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Components of DNA damage checkpoint pathway regulate ultraviolet exposure-dependent alterations of gene expression of FHIT and WWOX in chromosome fragile sites2005
Author(s)
Jshii, H., Mimori, K., Inageta, T., Murakumo, Y., Vecchione, A., Mori, M., Furukawa, Y
-
Journal Title
Cancer Res 3
Pages: 130-8
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Involvement of the tumor necrosis factor(TNF)/TNF-receptor system in leukemic cell apoptosis by an histone deacetylase inhibitor depsidepti de(FK228)2005
Author(s)
Sutheesophon, K., Nishimura, N., Furukawa, Y., Kawano, M., Ito, K., Kano, Y., Ishii. H., Furukawa, Y
-
Journal Title
J. Cell. Physiol 203
Pages: 387-97
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Journal Article] Differential roles of E-type cyclins during transformation of murine E2F- 1-deficient cells2005
Author(s)
Ishii, H., Mimori, K., Yoshikawa, Y., Mori, M., Furukawa, Y., Vecchione, A
-
Journal Title
DNA Cell. Biol 24
Pages: 173-9
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
-
-
[Presentation] Fhit Modulates the DNA Damage Checkpoint Response2006
Author(s)
Ishii, H-Mimori, K., Inoue, H., Inageta, T., Ishikawa, K., Semba, S., Druck, T., Trapasso, F., Mori, M., Croce, C.M., Huebner, K
Organizer
20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
Place of Presentation
Kyoto, Japan
Year and Date
20060618-23
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Arole of Rad9 in regulation of p53-dependent p21^waf1 activation after exposure to UV light2006
Author(s)
Ishikawa, K., Ishii. H., Kobayashi, M., Yamamoto, K.-i., Yokota, J., Karnitz, LM., Furukawa, Y., Ichimura, K
Organizer
20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
Place of Presentation
Kyoto, Japan
Year and Date
20060618-23
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Presentation] Identification of Bone-fide Characterstics of Esophageal Cancer by Adenobiral-FHIT Treatment2005
Author(s)
Mimori K, IshiLE, Okamoto M, Barnard, GF, Huebner K, Croce, CM, Mori, M
Organizer
The 58th Annual Cancer Symposium of SSO
Place of Presentation
Atlanta, USA
Year and Date
2005-03-06
Description
「研究成果報告書概要(欧文)」より
-
