2006 Fiscal Year Final Research Report Summary
Clinicopathological features of gastric neuroendocrine carcinomas and the roles of hASH1/HES1 in neuroendocrine differentiation of gastric cancers
| Project/Area Number |
17590316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
JIANG Shi-xu Kitasato University, Pathology, Assistant Professor, 医学部, 講師 (70276153)
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| Co-Investigator(Kenkyū-buntansha) |
MIKAMI Tetso Kitasato University, Pathology, Associate Professor, 医学部, 助教授 (90286352)
OKAYASU Isao Kitasato University, Pathology, Professor, 医学部, 教授 (20014342)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Gastric cancer / Neuroendocrine carcinoma / hASH1 / Hes1 |
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| Research Abstract |
The current histologic classifications of gastric cancers define only carcinoids and small cell carcinomas in the neuroendocrine (NE) category. This study aimed to characterize the histologic and clinical features of high-grade gastric NE carcinomas of nonsmall cell type, tentatively named large cell neuroendocrine carcinoma (LCNEC). Tumors with histologic features suspicious of NE differentiation were selected by a histologic review of 2835 resected gastric cancers, and those with a NE phenotype in >50% and 1% to 50% tumor cells assessed by expressing chromogranin A and/or synaptophysin were defined as LCNEC and adenocarcinoma with neuroendocrine differentiation (ACNED), respectively. One hundred ninety-nine tumors were selected and of the 109 positive for chromogranin A and/or synaptophysin, 42 and 44 met the criteria for LCNEC and ACNED, respectively. Generally, LCNECs demonstrated less predominant NE morphology than carcinoids, and could be roughly divided into solid (30 cases), tubular (7 cases), and scirrhous (5 cases) subtypes with reference to their main growth pattern. The prognosis of LCNECs was significantly worse than that of conventional adenocarcinomas (P<0.0001). Thus, this study shows that the spectrum of gastric NE tumors is broader than has previously been recognized and LCNEC is not only a distinct histopathologic entity, but also a distinct clinical entity. Furthermore, the prognosis of ACNEDs was also significantly worse than that of adenocarcinomas (P<0.0001), and some ACNEDs might actually have been LCNECs, and survival analysis showed that >20% positivity of NE markers could be enough to characterize LCNEC, as long as light microscopic NE morphology was present in the tumor.
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Research Products
(10 results)
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[Journal Article] Telomere Length, Telomerase Activity, and Expressions of Human Telomerase mRNA Component (hTERC) and Human Telomerase Reverse Transcriptase (hTERT) mRNA in Pulmonary Neuroendocrine Tumors.2007
Author(s)
Nishio Y, Nakanishi K, Ozeki Y, Jiang SX, Kameya T, Hebisawa A, Mukai M, Travis WD, Franks TJ, Kawai T
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Journal Title
Japanese Journal of Clinical Oncology 37-1
Pages: 16-22
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Neuroendocrine neoplasms of the lung : a prognostic spectrum.2006
Author(s)
Asamura H, Kameya T, Matsuno Y, Noguchi M, Tada H.Ishikawa Y, Yokose T, Jiang SX, Inoue T, Nakagawa K, Tajima K., Nagai K.
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Journal Title
Journal of Clinical Oncology 24-1
Pages: 70-76
Description
「研究成果報告書概要(欧文)」より
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