2006 Fiscal Year Final Research Report Summary
Identification of subtype-specific genomic alterations in adult T-cell leukemia/lymphoma
| Project/Area Number |
17590329
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
TAGAWA Hiroyuki Aichi Cancer Center, Molecular Medicine, Researcher, 遺伝子医療研究部, 主任研究員 (30373492)
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| Project Period (FY) |
2005 – 2006
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| Keywords | ATLL / Array CGH / Genomic alteration / Lymphoma / CARMA1 |
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| Research Abstract |
Aggressive adult T-cell leukemia/lymphoma (ATLL) such as acute and lymphoma types are fatal diseases with poor prognosis. Although these two subtypes feature different clinicopathological characteristics, no detailed comparative analyses of genomic/genetic alterations have been reported. We performed array-based comparative genomic hybridization for 17 acute and 49 lymphoma cases as well as real-time quantitative PCR to identify the target genes of recurrently amplified regions. Comparison of the genome profiles of acute and lymphoma types revealed that the lymphoma type had significantly more frequent gains at 1q, 2p, 4q, 7p and 7q, and losses of 10p, 13q, 16q and 18p, whereas the acute type showed a gain of 3/3p. Of the recurrent high-level amplifications found at 1p36, 6p25, 7p22, 7q and 14q32 in the lymphoma type, we were able to demonstrate that CARMA I is a possible target gene of the 7p22 amplification for the lymphoma type but not for the acute type. Furthermore, we found BCL11B overexpression in acute type irrespective of the 14q32 gain/amplification, while no or low expression of the gene in the lymphoma type. These results suggest that acute and lymphoma types are genomically distinct subtypes, and thus may develop tumors via disti
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[Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia.2006
Author(s)
Karnan, S., Tsuzuki, S., Kiyoi, H., Tagawa, H., Ueda, R., Seto, M., Naoe, T.
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Journal Title
Genes Chrom.Cancer 45
Pages: 420-425
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma.2006
Author(s)
Oshiro, A, Tagawa.H., Ohshima, K., Karube, K., Uike, N., Tashiro, Y., Utsunomiya, A., Masuda, M., Takasu, N., Nakamura, S., Morishima, Y., Seto, M.
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Expression profiling analysis of the CD5+ diffuse large B-cell lymphoma subgroup : development of a CD5 signature.2006
Author(s)
Suguro, M., Tagawa, H., Kagami, Y., Okamoto, M., Ohchima, K., Shiku, H., Morishima, Y., Nakamura, Y., Seto, M.
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Journal Title
Cancer Sci 97
Pages: 868-874
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Characterization of target genes at the 2p15-16 amplicon in diffuse large B-cell lymphoma.2006
Author(s)
Fukuhara, N., Tagawa, H., Kameoka, Y., Kasugai, Y., Karnan, S., Kameoka, J., Sasaki, T., Morishima, Y., Nakamura, S., Seto, M.
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Journal Title
Cancer Sci 97
Pages: 499-504
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genome-wide array-based CGH for mantle cell lymphoma : Identification of homozygous deletions of the proapoptotic gene BIM.2005
Author(s)
Tagawa, H., Karnan, S., Suzuki, R., Matsuo, K., Zhang, X., Ota, A., Morishima, Y., Nakamura, S., Seto, M.
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Journal Title
Oncogene 24
Pages: 1348-1358
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma.2005
Author(s)
Tagawa, H., Suguro, M., Tsuzuki, S., Matsuo, K., Karnan, S., Ohshima, K., Okamoto, M., Morishima, Y., Nakamura, S., Seto, M.
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Journal Title
Blood 106
Pages: 1770-1777
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genome-wide array-based comparative genomic hybridization of Natural killer cell lymphoma/leukemia Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T lymphoma, Nasal type.2005
Author(s)
Nakashima, Y., Tagawa, H., Suzuki, R., Karnan, S., Karube, K., Ohshima, K., Muta, K., Nawata, H., Morishima, Y., Nakamura, S., Seto, M.
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Journal Title
Genes Chrom. Cancer 44
Pages: 247-255
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Identification of CCND3 and BYSL as Candidate Targets for the 6p21 Amplification in Diffuse Large B-Cell Lymphoma.2005
Author(s)
Kasugai, Y., Tagawa, H., Kameoka, Y., Morishima, Y., Nakamura, S., Seto, M.
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Journal Title
Clin.Cancer Res. 11
Pages: 8265-8272
Description
「研究成果報告書概要(欧文)」より
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